Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accrued expenses and other current liabilities
Accrued employee compensation and benefits	$ 4,554	$ 6,429
Accrued external research and development expenses	7,685	3,980
Accrued professional fees	850	882
Current portion of operating lease liabilities	2,905	2,383
Other	958	570
Accrued expenses and other current liabilities	$ 16,952	$ 14,244
Operating Lease, Liability, Current, Statement of Financial Position [Extensible List]	Accrued expenses and other current liabilities	Accrued expenses and other current liabilities