Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 372,769	$ 438,680
Accounts receivable	10,000	1,000
Prepaid expenses and other current assets	9,454	7,965
Research and development incentives receivable	16,270	10,910
Total current assets	408,493	458,555
Property and equipment, net	16,815	3,123
Operating lease right-of-use assets	15,076	14,666
Other assets	5,098	3,448
Total assets	445,482	479,792
Current liabilities:
Accounts payable	4,859	2,721
Accrued expenses and other current liabilities	16,952	14,244
Deferred revenue, current portion	19,530	19,273
Total current liabilities	41,341	36,238
Long-term debt, net of discount	30,144	29,873
Operating lease liabilities, net of current portion	12,496	12,081
Deferred revenue, net of current portion	46,849	52,067
Other longterm liabilities	3,260	3,279
Total liabilities	134,090	133,538
Commitments and contingencies (Note 11)
Shareholders' equity:
Ordinary shares, 0.01 nominal value; 57,820,181 and 55,295,420 shares authorized at June 30, 2022 and December 31, 2021, respectively; 29,666,317 and 29,579,364 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively	385	384
Additional paid-in capital	584,152	567,637
Accumulated other comprehensive loss	(374)	(3,388)
Accumulated deficit	(272,771)	(218,379)
Total shareholders' equity	311,392	346,254
Total liabilities and shareholders' equity	$ 445,482	$ 479,792