Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (27,564)	$ (16,191)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	10,198	3,821
Depreciation and amortization	422	325
Non-cash interest	135	93
Changes in operating assets and liabilities:
Accounts receivable	991	3,520
Research and development incentives receivable	(2,774)	(2,277)
Prepaid expenses and other current assets	(1,341)	(922)
Operating lease rightofuse assets	650	(2,434)
Other assets	(748)	(353)
Accounts payable	(255)	(304)
Accrued expenses and other current liabilities	(2,337)	(1,858)
Operating lease liabilities	(105)	2,466
Deferred revenue	(3,850)	236
Other long-term liabilities	178	171
Net cash used in operating activities	(26,400)	(13,707)
Cash used in investing activities:
Purchases of property and equipment	(4,756)	(623)
Net cash used in investing activities	(4,756)	(623)
Cash flows from financing activities:
Proceeds from the issuance of ADSs, net of issuance costs		58,775
Proceeds from the exercise of share options and ordinary shares	450	284
Proceeds from issuance of debt		15,000
Net cash provided by financing activities	450	74,059
Effect of exchange rate changes on cash and cash equivalents	(603)	182
Net (decrease) increase in cash and cash equivalents	(31,309)	59,911
Cash and cash equivalents at beginning of period	438,680	135,990
Cash and cash equivalents at end of period	407,371	195,901
Supplemental disclosure of cash flow information
Cash paid for interest	664	429
Cash paid for income taxes	(35)
Cash paid for amounts included in the measurement of operating lease liabilities	375	199
Purchases of property and equipment included in accounts payable and accrued expenses	1,630	$ 76
Non-cash impact right-of-use asset and operating lease liabilities	$ 3,120