Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 407,371	$ 438,680
Accounts receivable		1,000
Prepaid expenses and other current assets	9,067	7,965
Research and development incentives receivable	13,328	10,910
Total current assets	429,766	458,555
Property and equipment, net	8,849	3,123
Operating lease right-of-use assets	16,750	14,666
Other assets	4,198	3,448
Total assets	459,563	479,792
Current liabilities:
Accounts payable	3,999	2,721
Accrued expenses and other current liabilities	12,265	14,244
Deferred revenue, current portion	19,150	19,273
Total current liabilities	35,414	36,238
Long-term debt, net of discount	30,008	29,873
Operating lease liabilities, net of current portion	14,093	12,081
Deferred revenue, net of current portion	46,428	52,067
Other longterm liabilities	3,362	3,279
Total liabilities	129,305	133,538
Commitments and contingencies (Note 11)
Shareholders' equity:
Ordinary shares, 0.01 nominal value; 57,070,181 and 55,295,420 shares authorized at March 31, 2022 and December 31, 2021, respectively; 29,644,438 and 29,579,364 shares issued and outstanding at March 31, 2022 and December 31, 2021, respectively	385	384
Additional paid-in capital	578,284	567,637
Accumulated other comprehensive loss	(2,468)	(3,388)
Accumulated deficit	(245,943)	(218,379)
Total shareholders' equity	330,258	346,254
Total liabilities and shareholders' equity	$ 459,563	$ 479,792