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<ACCEPTANCE-DATETIME>20220415160156
ACCESSION NUMBER:		0001558370-22-005515
CONFORMED SUBMISSION TYPE:	PRE 14A
PUBLIC DOCUMENT COUNT:		13
CONFORMED PERIOD OF REPORT:	20220627
FILED AS OF DATE:		20220415
DATE AS OF CHANGE:		20220415

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		PRE 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38916
		FILM NUMBER:		22830054

	BUSINESS ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212
</SEC-HEADER>
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<TYPE>PRE 14A
<SEQUENCE>1
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<DESCRIPTION>PRE 14A
<TEXT>
Document 1 - file: tmb-20220627xpre14a.htm

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Document 2 - file: tmb-20220627xpre14a041.jpg

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<TEXT>
Document 3 - file: tmb-20220627xpre14a018.jpg

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<FILENAME>tmb-20220627xpre14a036.jpg
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<TEXT>
Document 4 - file: tmb-20220627xpre14a036.jpg

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<TEXT>
Document 5 - file: tmb-20220627xpre14a014.jpg

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Document 6 - file: tmb-20220627xpre14a020.jpg

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<TEXT>
Document 7 - file: tmb-20220627xpre14a002.jpg

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<SEQUENCE>8
<FILENAME>tmb-20220627xpre14a019.jpg
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<TEXT>
Document 8 - file: tmb-20220627xpre14a019.jpg

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Document 9 - file: tmb-20220627xpre14a025.jpg

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Document 10 - file: tmb-20220627xpre14a031.jpg

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<TEXT>
Document 11 - file: tmb-20220627xpre14a010.jpg

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Document 12 - file: tmb-20220627xpre14a040.jpg

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<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>tmb-20220627xpre14a008.jpg
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<TEXT>
Document 13 - file: tmb-20220627xpre14a008.jpg

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