Property and equipment, net (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Property and equipment, net
Property and equipment, gross	$ 7,923	$ 6,349
Less: Accumulated depreciation and amortization	(4,800)	(4,032)
Property and equipment, net	3,123	2,317
Depreciation expense	1,400	1,300	$ 1,000
Laboratory equipment
Property and equipment, net
Property and equipment, gross	6,746	5,583
Leasehold improvements
Property and equipment, net
Property and equipment, gross	809	383
Computer equipment and software
Property and equipment, net
Property and equipment, gross	143	188
Furniture and office equipment
Property and equipment, net
Property and equipment, gross	$ 225	$ 195

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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