Nature of the business and basis of presentation- Liquidity (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Nature of the business and basis of presentation
Cash and cash equivalents	$ 438,700
Net loss	66,819	$ 51,010	$ 30,608
Accumulated deficit	$ 218,379	$ 151,560