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Significant agreements - Oxurion Collaboration Agreement (Details)
$ in Thousands, € in Millions
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2021
USD ($)
Sep. 30, 2020
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2021
EUR (€)
Sep. 30, 2020
USD ($)
Dec. 31, 2020
USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Revenue from collaborative arrangement | $ $ 4,333 $ 3,842 $ 7,926   $ 6,542  
Oxurion            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Threshold period of notice required for termination of agreement     90 days 90 days    
Revenue recognized | $   2,400     2,400  
Revenue from collaborative arrangement | $ $ 0 $ 2,362 $ 0   $ 2,362 $ 0
Oxurion | Development milestone            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Potential milestone payments       € 8.3    
Revenue under contracts with customer from milestone payment       3.8    
Oxurion | Regulatory milestone            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Potential milestone payments       16.5    
Oxurion | Granting first regulatory approval or first indication            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Potential milestone payments       € 5.0