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Significant agreements - Ionis Share Purchase Agreement (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Jul. 09, 2021
Sep. 30, 2021
Jun. 30, 2021
Mar. 31, 2021
Sep. 30, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Aggregate purchase price   $ 29,843 $ 13,977 $ 58,775 $ 46,323
Ionis Share Purchase Agreement          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Total share premium $ 3,400        
Ionis Share Purchase Agreement | American Depositary Shares          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Aggregate purchase price   $ 7,558      
Ionis | Ionis Share Purchase Agreement          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Shares issued (in shares) 282,485        
Purchase price per share $ 38.94        
Aggregate purchase price $ 11,000        
Fair Value Of Shares Held 7,600        
Total share premium $ 3,400        
Ionis | Ionis Share Purchase Agreement | American Depositary Shares          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Purchase price per share $ 31.11