<SEC-DOCUMENT>0001558370-21-005323-index.html : 20210430
<SEC-HEADER>0001558370-21-005323.hdr.sgml : 20210430
<ACCEPTANCE-DATETIME>20210430070052
ACCESSION NUMBER:		0001558370-21-005323
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		7
CONFORMED PERIOD OF REPORT:	20210628
FILED AS OF DATE:		20210430
DATE AS OF CHANGE:		20210430

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38916
		FILM NUMBER:		21873674

	BUSINESS ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEF 14A
<SEQUENCE>1
<FILENAME>tmb-20210628xdef14a.htm
<DESCRIPTION>DEF 14A
<TEXT>
Document 1 - file: tmb-20210628xdef14a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>tmb-20210628xdef14a012.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: tmb-20210628xdef14a012.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>tmb-20210628xdef14a024.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: tmb-20210628xdef14a024.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>tmb-20210628xdef14a019.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: tmb-20210628xdef14a019.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>tmb-20210628xdef14a023.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: tmb-20210628xdef14a023.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>tmb-20210628xdef14a013.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: tmb-20210628xdef14a013.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>tmb-20210628xdef14a001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: tmb-20210628xdef14a001.jpg

</DOCUMENT>
</SEC-DOCUMENT>