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Significant agreements - Oxurion Collaboration Agreement (Details)
$ in Thousands, € in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2020
USD ($)
Sep. 30, 2019
USD ($)
Sep. 30, 2020
EUR (€)
Sep. 30, 2020
USD ($)
Sep. 30, 2019
USD ($)
Sep. 30, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Significant agreements.                
Revenue from collaborative arrangement $ 3,842 $ 614   $ 6,542 $ 8,520      
Deferred revenue           $ 33,275 $ 5,657 $ 14,635
Revenue recognized 1,267 173   $ 3,496 5,596      
Oxurion                
Significant agreements.                
Threshold period of notice required for termination of agreement     90 days 90 days        
Revenue from collaborative arrangement 2,362 $ 0   $ 2,362 $ 0      
Deferred revenue           $ 0    
Revenue recognized $ 2,400     $ 2,400        
Oxurion | Development milestone                
Significant agreements.                
Upfront cash payment | €     € 1.0          
Potential milestone payments | €     8.3          
Revenue under contracts with customer from milestone payment | €     3.8          
Oxurion | Regulatory milestone                
Significant agreements.                
Potential milestone payments | €     16.5          
Oxurion | Granting first regulatory approval or first indication                
Significant agreements.                
Potential milestone payments | €     € 5.0