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Significant agreements - Oxurion Collaboration Agreement (Details)
$ in Thousands, € in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2020
USD ($)
Jun. 30, 2019
USD ($)
Jun. 30, 2020
EUR (€)
Jun. 30, 2020
USD ($)
Jun. 30, 2019
USD ($)
Jun. 30, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Significant agreements.                
Revenue from collaborative arrangement | $ $ 1,571 $ 1,522   $ 2,700 $ 7,906      
Deferred revenue | $           $ 33,082 $ 5,657 $ 14,635
Oxurion                
Significant agreements.                
Threshold period of notice required for termination of agreement     90 days 90 days        
Revenue from collaborative arrangement | $ $ 0 $ 0   $ 0 $ 0      
Deferred revenue | $           $ 0    
Oxurion | Development milestone                
Significant agreements.                
Upfront cash payment     € 1.0          
Potential milestone payments     8.3          
Revenue under contracts with customer from milestone payment     1.8          
Oxurion | Regulatory milestone                
Significant agreements.                
Potential milestone payments     16.5          
Oxurion | Granting first regulatory approval or first indication                
Significant agreements.                
Potential milestone payments     € 5.0