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Significant agreements - Sanofi Collaboration Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Aug. 31, 2017
USD ($)
employee
Dec. 31, 2019
USD ($)
Sep. 30, 2019
USD ($)
Jun. 30, 2019
USD ($)
Mar. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Significant agreements.                        
Transaction price $ 14,200                      
Revenue recognized by non exercising of option                   $ 9,984    
Revenue from collaborative arrangement   $ 5,281 $ 614 $ 1,522 $ 6,384 $ 1,057 $ 1,610 $ 1,661 $ 2,808 13,801 $ 7,136 $ 2,060
Deferred revenue   5,657       14,635       5,657 14,635 14,467
Sickle Cell Research License and Related Services                        
Significant agreements.                        
Transaction price 1,405                      
Hemophilia Research License and Related Services                        
Significant agreements.                        
Transaction price 2,811                      
Sickle Cell License Option Material Right                        
Significant agreements.                        
Transaction price 5,286                      
Hemophilia License Option Material Right                        
Significant agreements.                        
Transaction price 4,698                      
Sanofi                        
Significant agreements.                        
Option fee payment to obtain the screening services $ 5,000                      
Term of research program 3 years                      
Renewal period of Research 1 year                      
Upfront cash payment $ 10,000                      
Non refundable payment for services during the BV Bicycle Research Term $ 4,200                      
Threshold period of notice required for termination of agreement 30 days                      
Transaction price $ 14,200 14,900               14,900    
Revenue from collaborative arrangement                   10,724 4,007 355
Deferred revenue   $ 0       $ 9,908       0 $ 9,908 $ 14,467
Sanofi | Sickle Cell Research License and Related Services                        
Significant agreements.                        
Non refundable payment for services during the BV Bicycle Research Term 1,400                      
Revenue recognized by non exercising of option                   5,300    
Sanofi | Hemophilia Research License and Related Services                        
Significant agreements.                        
Non refundable payment for services during the BV Bicycle Research Term 2,800                      
Sanofi | Hemophilia License Option Material Right                        
Significant agreements.                        
Revenue recognized by non exercising of option                   $ 4,700    
Sanofi | Program 3                        
Significant agreements.                        
Non refundable payment for services during the BV Bicycle Research Term $ 1,400                      
Sanofi | Minimum                        
Significant agreements.                        
Number of FTE | employee 2                      
Sanofi | Development milestone                        
Significant agreements.                        
Option fee payable in order to obtain worldwide development and exploitation rights $ 5,000                      
Sanofi | Development milestone | Sickle Cell License Option Material Right                        
Significant agreements.                        
Potential milestone payments 47,500                      
Sanofi | Development milestone | Hemophilia License Option Material Right                        
Significant agreements.                        
Potential milestone payments 67,000                      
Sanofi | Regulatory milestone                        
Significant agreements.                        
Potential milestone payments 104,000                      
Sanofi | Commercial milestone                        
Significant agreements.                        
Potential milestone payments 55,000                      
Sanofi | Commercialization license per candidate                        
Significant agreements.                        
Potential milestone payments $ 5,000