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Property and equipment, net (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Property and equipment, net          
Property and equipment, gross $ 4,410   $ 4,410   $ 3,751
Less: Accumulated depreciation and amortization (2,258)   (2,258)   (1,933)
Property and equipment, net 2,152   2,152   1,818
Depreciation expense 200 $ 200 700 $ 500  
Laboratory equipment          
Property and equipment, net          
Property and equipment, gross 3,784   3,784   3,356
Leasehold improvements          
Property and equipment, net          
Property and equipment, gross 291   291   75
Computer equipment and software          
Property and equipment, net          
Property and equipment, gross 222   222   221
Furniture and office equipment          
Property and equipment, net          
Property and equipment, gross $ 113   $ 113   $ 99