SEC FORM 3

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Thompson Travis Alvin

(Last)

(First)

(Middle)

C/O BICYCLE THERAPEUTICS PLC

BLOCKS A & B, PORTWAY BUILDING

(Street)

CAMBRIDGE

CB21 6GS

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
06/22/2023

3. Issuer Name and Ticker or Trading Symbol
BICYCLE THERAPEUTICS plc [ BCYC ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Accounting Officer

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Ordinary Shares	8,094⁽¹⁾	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
Employee Stock Option (right to buy)	⁽²⁾	09/17/2028	Ordinary Shares	3,929	$1.83⁽³⁾	D
Employee Stock Option (right to buy)	⁽²⁾	04/24/2029	Ordinary Shares	456	$8.03⁽³⁾	D
Employee Stock Option (right to buy)	⁽⁴⁾	01/02/2030	Ordinary Shares	14,063	$9.82	D
Employee Stock Option (right to buy)	⁽⁵⁾	01/04/2031	Ordinary Shares	23,500	$17.95	D
Employee Stock Option (right to buy)	⁽⁶⁾	01/03/2032	Ordinary Shares	9,000	$60.87	D
Employee Stock Option (right to buy)	⁽⁷⁾	01/03/2033	Ordinary Shares	40,000	$29.6	D

Explanation of Responses:

1. Represents restricted stock unit ("RSU") awards. 3,094 RSUs shall vest in eleven equal quarterly installments commencing on July 3, 2023. 5,000 RSUs shall vest one-fourth (1/4) of the total number of RSUs on January 3, 2024, and the remaining RSUs shall vest in 12 equal quarterly installments thereafter.

2. Fully vested and exercisable.

3. This exercise price is in US Dollars and reflects the conversion of GBP to USD at an exchange rate of $1.2605 to GBP 1.00 as of May 22, 2019.

4. This option vested one-fourth (1/4) of the total number of shares on January 2, 2021, and the remaining shares vested or shall vest in 36 equal monthly installments at the end of each calendar month thereafter.

5. This option vested one-fourth (1/4) of the total number of shares on January 4, 2022, and the remaining shares vested or shall vest in 36 equal monthly installments thereafter.

6. This option vested one-fourth (1/4) of the total number of shares on January 3, 2023, and the remaining shares vested or shall vest in 36 equal monthly installments thereafter.

7. This option shall vest one-fourth (1/4) of the total number of shares underlying the option on January 3, 2024, and the remaining shares vest in 36 equal monthly installments thereafter.

Remarks:

Exhibit List - Exhibit 24 - Power of Attorney

	/s/ Jason Minio, Attorney-in-Fact	07/03/2023
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.