<SEC-DOCUMENT>0001193125-21-247279-index.html : 20210816
<SEC-HEADER>0001193125-21-247279.hdr.sgml : 20210816
<ACCEPTANCE-DATETIME>20210816111929
ACCESSION NUMBER:		0001193125-21-247279
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20210816
DATE AS OF CHANGE:		20210816
GROUP MEMBERS:		SV LIFE SCIENCES FUND V (GP), L.P.
GROUP MEMBERS:		SV LIFE SCIENCES FUND V STRATEGIC PARTNERS, L.P.
GROUP MEMBERS:		SV LIFE SCIENCES FUND V, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91023
		FILM NUMBER:		211175615

	BUSINESS ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SVLSF V, LLC
		CENTRAL INDEX KEY:			0001644160
		IRS NUMBER:				264430055
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		C/O SV LIFE SCIENCES ADVISERS, LLC
		STREET 2:		ONE BOSTON PLACE, SUITE 3900
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02108
		BUSINESS PHONE:		617-367-8100

	MAIL ADDRESS:	
		STREET 1:		C/O SV LIFE SCIENCES ADVISERS, LLC
		STREET 2:		ONE BOSTON PLACE, SUITE 3900
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02108
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>d201082dsc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
Document 1 - file: d201082dsc13da.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>d201082dex991.htm
<DESCRIPTION>EX-99.1
<TEXT>
Document 2 - file: d201082dex991.htm

</DOCUMENT>
</SEC-DOCUMENT>