<SEC-DOCUMENT>0001104659-23-065534-index.html : 20230526
<SEC-HEADER>0001104659-23-065534.hdr.sgml : 20230526
<ACCEPTANCE-DATETIME>20230526165332
ACCESSION NUMBER:		0001104659-23-065534
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		12
FILED AS OF DATE:		20230526
DATE AS OF CHANGE:		20230526
EFFECTIVENESS DATE:		20230526

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-272248
		FILM NUMBER:		23969947

	BUSINESS ADDRESS:	
		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
		STREET 2:		GRANTA PARK, GREAT ABINGTON
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		BLOCKS A & B, PORTWAY BUILDING
		STREET 2:		GRANTA PARK, GREAT ABINGTON
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB21 6GS

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>tm2317110-1_s3.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: tm2317110-1_s3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.3
<SEQUENCE>2
<FILENAME>tm2317110d2_ex4-3.htm
<DESCRIPTION>EXHIBIT 4.3
<TEXT>
Document 2 - file: tm2317110d2_ex4-3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.5
<SEQUENCE>3
<FILENAME>tm2317110d2_ex4-5.htm
<DESCRIPTION>EXHIBIT 4.5
<TEXT>
Document 3 - file: tm2317110d2_ex4-5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.6
<SEQUENCE>4
<FILENAME>tm2317110d2_ex4-6.htm
<DESCRIPTION>EXHIBIT 4.6
<TEXT>
Document 4 - file: tm2317110d2_ex4-6.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.7
<SEQUENCE>5
<FILENAME>tm2317110d2_ex4-7.htm
<DESCRIPTION>EXHIBIT 4.7
<TEXT>
Document 5 - file: tm2317110d2_ex4-7.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>6
<FILENAME>tm2317110d2_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 6 - file: tm2317110d2_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.2
<SEQUENCE>7
<FILENAME>tm2317110d2_ex5-2.htm
<DESCRIPTION>EXHIBIT 5.2
<TEXT>
Document 7 - file: tm2317110d2_ex5-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>8
<FILENAME>tm2317110d2_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 8 - file: tm2317110d2_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>9
<FILENAME>tm2317110d2_ex-filingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 9 - file: tm2317110d2_ex-filingfees.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>lg_bicycle-bw.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 10 - file: lg_bicycle-bw.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>tm2317110d2_ex5-1img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 11 - file: tm2317110d2_ex5-1img001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>tm2317110d2_ex5-2img001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 12 - file: tm2317110d2_ex5-2img001.jpg

</DOCUMENT>
</SEC-DOCUMENT>