<SEC-DOCUMENT>0001104659-21-005850-index.html : 20210120
<SEC-HEADER>0001104659-21-005850.hdr.sgml : 20210120
<ACCEPTANCE-DATETIME>20210120163017
ACCESSION NUMBER:		0001104659-21-005850
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210120
DATE AS OF CHANGE:		20210120
GROUP MEMBERS:		VERTEX VENTURE HOLDINGS LTD.
GROUP MEMBERS:		VERTEX VENTURE MANAGEMENT PTE. LTD.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91023
		FILM NUMBER:		21539108

	BUSINESS ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Vertex Global HC Fund I Pte. Ltd.
		CENTRAL INDEX KEY:			0001663140
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			U0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		250 NORTH BRIDGE ROAD
		STREET 2:		#05-01 RAFFLES CITY TOWER
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			179101
		BUSINESS PHONE:		6568288088

	MAIL ADDRESS:	
		STREET 1:		250 NORTH BRIDGE ROAD
		STREET 2:		#05-01 RAFFLES CITY TOWER
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			179101

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Vertex Global Healthcare Fund I Pte Ltd.
		DATE OF NAME CHANGE:	20160107
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>tm213684d1_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
Document 1 - file: tm213684d1_sc13da.htm

</DOCUMENT>
</SEC-DOCUMENT>