<SEC-DOCUMENT>0001104659-20-070493-index.html : 20200605
<SEC-HEADER>0001104659-20-070493.hdr.sgml : 20200605
<ACCEPTANCE-DATETIME>20200605172806
ACCESSION NUMBER:		0001104659-20-070493
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		13
FILED AS OF DATE:		20200605
DATE AS OF CHANGE:		20200605

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-238996
		FILM NUMBER:		20947425

	BUSINESS ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>tm2021794-1_s3.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: tm2021794-1_s3.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-1.2 <SEQUENCE>2 <FILENAME>tm2021794d2_ex1-2.htm <DESCRIPTION>EXHIBIT 1.2 <TEXT> Document 2 - file: tm2021794d2_ex1-2.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-4.4 <SEQUENCE>3 <FILENAME>tm2021794d2_ex4-4.htm <DESCRIPTION>EXHIBIT 4.4 <TEXT> Document 3 - file: tm2021794d2_ex4-4.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-4.5 <SEQUENCE>4 <FILENAME>tm2021794d2_ex4-5.htm <DESCRIPTION>EXHIBIT 4.5 <TEXT> Document 4 - file: tm2021794d2_ex4-5.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-4.7 <SEQUENCE>5 <FILENAME>tm2021794d2_ex4-7.htm <DESCRIPTION>EXHIBIT 4.7 <TEXT> Document 5 - file: tm2021794d2_ex4-7.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-4.8 <SEQUENCE>6 <FILENAME>tm2021794d2_ex4-8.htm <DESCRIPTION>EXHIBIT 4.8 <TEXT> Document 6 - file: tm2021794d2_ex4-8.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-4.9 <SEQUENCE>7 <FILENAME>tm2021794d2_ex4-9.htm <DESCRIPTION>EXHIBIT 4.9 <TEXT> Document 7 - file: tm2021794d2_ex4-9.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-5.1 <SEQUENCE>8 <FILENAME>tm2021794d2_ex5-1.htm <DESCRIPTION>EXHIBIT 5.1 <TEXT> Document 8 - file: tm2021794d2_ex5-1.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-5.2 <SEQUENCE>9 <FILENAME>tm2021794d2_ex5-2.htm <DESCRIPTION>EXHIBIT 5.2 <TEXT> Document 9 - file: tm2021794d2_ex5-2.htm
</DOCUMENT> <DOCUMENT> <TYPE>EX-23.1 <SEQUENCE>10 <FILENAME>tm2021794d2_ex23-1.htm <DESCRIPTION>EXHIBIT 23.1 <TEXT> Document 10 - file: tm2021794d2_ex23-1.htm
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>11 <FILENAME>lg_bicycle-4c.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 11 - file: lg_bicycle-4c.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>12 <FILENAME>tm2021794d2_ex5-1img01.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 12 - file: tm2021794d2_ex5-1img01.jpg
</DOCUMENT> <DOCUMENT> <TYPE>GRAPHIC <SEQUENCE>13 <FILENAME>tm2021794d2_ex5-2img001.jpg <DESCRIPTION>GRAPHIC <TEXT> Document 13 - file: tm2021794d2_ex5-2img001.jpg
</DOCUMENT> </SEC-DOCUMENT>