<SEC-DOCUMENT>0000899140-20-000427-index.html : 20200915
<SEC-HEADER>0000899140-20-000427.hdr.sgml : 20200915
<ACCEPTANCE-DATETIME>20200915163223
ACCESSION NUMBER:		0000899140-20-000427
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20200915
DATE AS OF CHANGE:		20200915
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BICYCLE THERAPEUTICS plc
		CENTRAL INDEX KEY:			0001761612
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91023
		FILM NUMBER:		201176326

	BUSINESS ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT
		BUSINESS PHONE:		011441223261503

	MAIL ADDRESS:	
		STREET 1:		B900 BABRAHAM RESEARCH CAMPUS
		CITY:			CAMBRIDGE
		STATE:			X0
		ZIP:			CB22 3AT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BICYCLE THERAPEUTICS Ltd
		DATE OF NAME CHANGE:	20181212

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>b091520a.htm
<DESCRIPTION>SCHEDULE 13G
<TEXT>
Document 1 - file: b091520a.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>b091520b.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
Document 2 - file: b091520b.htm

</DOCUMENT>
</SEC-DOCUMENT>