Leases - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended
	Oct. 31, 2022	Sep. 30, 2021	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Leases [Line Items]
ROU asset			$ 29,583		$ 31,633
Lease liability			33,823
Operating lease costs			2,600	$ 1,600
Cash paid for operating lease			2,100	1,200
Variable lease costs			$ 100	$ 1,200
Operating lease, weighted average remaining lease term			6 years 8 months 26 days
Operating lease, weighted average discount rate, percent			6.19%
Waltham Leases
Leases [Line Items]
Expiration date		Jul. 30, 2030
Operating lease, existence of option to extend		true
Lease, option to extend			The Company has the option to renew the leased space for an additional one time period of five years with written notice from the Company. At March 31, 2023, the Company has no reasonable certainty that this option to extend will be exercised.
Tenant improvement allowance to be reimbursed		$ 3,100
Tenant improvement allowance, reimbursement period		2 years
Tenant improvement allowance			$ 900
Lease commencement month and year		2021-09
Additional one time lease period		5 years
New Lease Agreement with BP Bay Colony LLC
Leases [Line Items]
ROU asset		$ 6,000
Lease liability		6,000
Sublease with AMAG Pharmaceuticals
Leases [Line Items]
ROU asset		17,300
Lease liability		$ 17,300
2022 SOW Under the DMS Agreement
Leases [Line Items]
Lease expiration month and year	2024-12
ROU asset	$ 14,700
Lease liability	14,700
Utilization fee	$ 16,300
Lessee operating lease, lease term including renewal option	2 years 3 months