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Income Taxes - Reconciliation of Expected Statutory Federal Income Tax Provision to Actual Income Tax Provision (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Expense Benefit Continuing Operations Income Tax Reconciliation [Abstract]    
Income taxes at statutory rates $ (8,201) $ (6,261)
Stock-based compensation 451 97
Permanent items 31 15
Federal research and orphan drug credits (1,713) (445)
Foreign rate differential 72 367
Change in federal valuation allowance 9,360 6,227
Income tax expense (benefit) $ 0 $ 0