Consolidated Statements of Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive (Loss) Income	Accumulated Deficit	IPO	IPO Common Stock	IPO Additional Paid-in Capital	October 2020 Public Offering	October 2020 Public Offering Common Stock	October 2020 Public Offering Additional Paid-in Capital	Private Placement	Private Placement Common Stock	Private Placement Additional Paid-in Capital	At-The-Market	At-The-Market Common Stock	At-The-Market Additional Paid-in Capital	Redeemable Convertible Preferred Stock
Beginning Balance at Dec. 31, 2018	$ (117,406)	$ 56	$ 7,256		$ (124,718)
Beginning Balance, Shares at Dec. 31, 2018		5,565,368
Redeemable convertible preferred stock, Beginning Balance at Dec. 31, 2018																		$ 251,434
Redeemable convertible preferred stock, Beginning Balance, Shares at Dec. 31, 2018																		119,308,387
Issuance of Series B redeemable convertible preferred stock, net of issuance costs of $95																		$ 37,901
Issuance of Series B redeemable convertible preferred stock, net of issuance costs of $95, Shares																		11,308,397
Accretion of redeemable convertible preferred stock to redemption value																		$ 12,714
Accretion of redeemable convertible preferred stock to redemption value	(12,714)		(12,714)
Vesting of restricted common stock		$ 15	(15)
Vesting of restricted common stock, Shares		1,559,126
Exercise of common stock options	185	$ 2	183
Exercise of common stock options, Shares		184,966
Issuance of common stock related to license agreement	113		113
Issuance of common stock related to license agreement, Shares		16,725
Stock-based compensation	7,028		7,028
Other comprehensive income (loss)	16			$ 16
Net loss	(78,326)				(78,326)
Redeemable convertible preferred stock, Ending Balance at Dec. 31, 2019																		$ 302,049
Redeemable convertible preferred stock, Ending Balance, Shares at Dec. 31, 2019																		130,616,784
Ending Balance at Dec. 31, 2019	(201,104)	$ 73	1,851	16	(203,044)
Ending Balance, Shares at Dec. 31, 2019		7,326,185
Accretion of redeemable convertible preferred stock to redemption value																		$ 1,277
Accretion of redeemable convertible preferred stock to redemption value	(1,277)		(1,277)
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering																		$ (303,326)
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering, Shares																		(130,616,784)
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering	303,326	$ 291	303,035
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering, Shares		29,127,523
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs						$ 188,323	$ 122	$ 188,201	$ 126,624	$ 58	$ 126,566
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares							12,176,471			5,750,000
Vesting of restricted common stock		$ 16	(16)
Vesting of restricted common stock, Shares		1,638,968
Exercise of common stock options	3,155	$ 9	3,146
Exercise of common stock options, Shares		859,724
Issuance of common stock related to license agreement	5,751	$ 4	5,747
Issuance of common stock related to license agreement, Shares		375,307
Stock-based compensation	15,380		15,380
Other comprehensive income (loss)	(25)			(25)
Net loss	(194,592)				(194,592)
Ending Balance at Dec. 31, 2020	245,561	$ 573	642,633	(9)	(397,636)
Ending Balance, Shares at Dec. 31, 2020		57,254,178
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs												$ 252,005	$ 28	$ 251,977	$ 496,623	$ 49	$ 496,574
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares													2,795,700			4,907,195
Issuance of common stock for success payment liability	30,000	$ 4	29,996
Issuance of common stock for success payment liability, Shares		349,650
Issuance of common stock to acquire Guide	120,032	$ 10	120,022
Issuance of common stock to acquire Guide, Shares		1,087,153
Vesting of restricted common stock		$ 10	(10)
Vesting of restricted common stock, Shares		1,020,887
Exercise of common stock options	$ 9,626	$ 10	9,616
Exercise of common stock options, Shares	974,662	974,662
Stock-based compensation	$ 43,570		43,570
Other comprehensive income (loss)	(41)			(41)
Net loss	(370,638)				(370,638)
Ending Balance at Dec. 31, 2021	$ 826,738	$ 684	$ 1,594,378	$ (50)	$ (768,274)
Ending Balance, Shares at Dec. 31, 2021		68,389,425