Commitments and contingencies (Details) $ in Thousands	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Jul. 10, 2020 ft²	Feb. 29, 2020 USD ($)
Lease agreement term				7 years
Square feet of office | ft²			6,647
Minimum payments during the term				$ 2,300
Non-cancelable purchase and other commitments with contract research organizations and contract manufacturing organizations	$ 7,239
Total lease liability	1,310
Operating lease liability, noncurrent	$ 1,079	$ 1,311
Accounting Standards Update 2016-13 [Member]
Operating Lease, Liability, Statement of Financial Position [Extensible Enumeration]	Operating lease liability, noncurrent, Prepaid Expense and Other Assets, Current
Short-term Liabilities	$ 231