Nature of the business and basis of presentation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Net loss	$ 112,033	$ 100,777
Accumulated deficit	422,337	$ 310,304
Cash, cash equivalents and short-term marketable securities	$ 351,449