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                          April 26, 2022

       James Coffey
       Chief Operating Officer and General Counsel
       Advent Technologies Holdings, Inc.
       200 Clarendon Street
       Boston, MA 02116

                                                        Re: Advent Technologies
Holdings, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed April 21,
2022
                                                            File No. 333-264421

       Dear Mr. Coffey:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Gregory
Herbers at 202-551-8028 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Manufacturing
       cc:                                              Katherine Blair