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Equity Method and Other Equity Investments - Additional Information (Detail)
1 Months Ended 3 Months Ended 12 Months Ended
Nov. 01, 2021
USD ($)
Oct. 31, 2021
shares
Oct. 31, 2019
USD ($)
Director
Mar. 31, 2021
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Mar. 31, 2019
USD ($)
Schedule Of Equity Method Investments [Line Items]                  
Gain on conversion from equity method investment to investment in equity securities         $ 0 $ 68,538,000      
Unrealized loss on ongoing mark-to-market adjustments of investment in equity security         11,953,000 40,830,000      
Other income (expense)         1,571,000 1,197,000 $ (3,338,000)    
Fair value of warrants         600,000 2,100,000      
Equity security investment         43,653,000 49,148,000      
LianBio                  
Schedule Of Equity Method Investments [Line Items]                  
Other income (expense)             $ 3,300,000    
Equity security investment         8,200,000 30,800,000      
LianBio | Equity Method Investee's IPO                  
Schedule Of Equity Method Investments [Line Items]                  
Ownership interest 4.70%                
Unrealized loss on ongoing mark-to-market adjustments of investment in equity security         $ 22,600,000 $ 37,700,000      
LianBio | Equity Method Investee's IPO | Other Income (Expense)                  
Schedule Of Equity Method Investments [Line Items]                  
Gain on conversion from equity method investment to investment in equity securities $ 68,500,000                
LianBio | Common Stock                  
Schedule Of Equity Method Investments [Line Items]                  
Ownership interest             6.00%    
Bridge Bio Pharma Limited Liability Company | Entities Affiliated With Perceptive Life Sciences Master Fund Ltd | LianBio                  
Schedule Of Equity Method Investments [Line Items]                  
Ownership interest     10.00%         10.00%  
Number of directors appoint or removal | Director     1            
Ownership interest, value     $ 3,800,000         $ 0  
Impairments related investment               0  
Warrant to purchase percentage     10.00%            
Warrants to purchase common stock | shares   347,569              
PellePharm, Inc                  
Schedule Of Equity Method Investments [Line Items]                  
Ownership interest, value             $ 0   $ 0
Impairments related investment       $ 0          
Preferred stock ownership percentage         61.90%        
Equity security investment               $ 0