Restructuring, Impairment and Related Charges - Schedule of Activity Related to Restructuring Liabilities Associated to Restructuring Initiatives (Details) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2022
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	$ 11,223
Reclassification of final payment obligation related to a manufacturing agreement that was recognized in the prior period (see Note 13)		$ 2,185
Restructuring, impairment and related charges	5,016	36,074
Cash payments	(9,421)	(17,616)
Noncash activities	(67)	(13,892)
Restructuring liabilities, balance	6,751	6,751
Accounts Payable
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	117	117
Accrued Compensation and Benefits
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	508	508
Accrued Research and Development Liabilities
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	4,986	4,986
Other Accrued Liabilities
Restructuring Cost and Reserve [Line Items]
Restructuring liabilities, balance	$ 1,140	$ 1,140