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Note 11 - Stock Option Plan and Stock-based Compensation (Details Textual) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares) 192,898 65,471 112,932
Share-based Payment Arrangement, Expense $ 106,713 $ 0  
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total 281,397 $ 0  
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Payments $ 0    
Share-based Goods and Nonemployee Services Transaction, Valuation Method, Expected Dividend Rate 0.00%    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares) 127,427 0  
Maximum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term (Year) 6 years 29 days    
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate 93.90%    
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate 1.31%    
Minimum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term (Year) 5 years 2 months 12 days    
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate 87.10%    
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate 0.95%    
Equity Incentive Plan 2006 [Member]      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares) 65,471    
Equity Incentive Plan 2020 [Member]      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares) 1,384,761    
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Percent of Increase 10.00%    
Equity Incentive Plan 2020 [Member] | Maximum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year) 10 years    
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares) 1,384,761