Leases - Additional Information (Details) $ in Thousands	1 Months Ended		3 Months Ended		6 Months Ended
	Feb. 28, 2021 USD ($) ft²	Mar. 31, 2020 USD ($) ft²	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)
Lessee, Lease, Description [Line Items]
Operating lease right-of-use assets			$ 21,251		$ 21,251		$ 24,707	[1]
Lease liabilities			30,164		30,164		31,091
Lease payments			1,500	$ 1,200	2,400	$ 2,300
Impairment of long-lived assets			2,900		2,916	$ 0
Impairment of long-lived assets, right-of-use asset			2,300
Impairment of long-lived assets, related leasehold improvements			600		600
Research and development expenses
Lessee, Lease, Description [Line Items]
Impairment of long-lived assets			1,900
General and administrative expenses
Lessee, Lease, Description [Line Items]
Impairment of long-lived assets			1,000
301 Binney Street, Cambridge, Massachusetts
Lessee, Lease, Description [Line Items]
Lease term		11 years
Facility size | ft²		40,514
Initial annual base rent		$ 4,100
Escalating rent payments, percent		3.00%
Letter of credit		$ 2,000
Tenant improvement allowances		$ 3,700
Improvement costs incurred, reimbursed by lessor					3,700
Operating lease right-of-use assets			19,200		19,200		21,900
Lease liabilities			$ 27,000		$ 27,000		28,000
Remaining lease term			7 years 8 months		7 years 8 months
Incremental borrowing rate			8.50%		8.50%
San Mateo, California. February 2021 Lease Agreement
Lessee, Lease, Description [Line Items]
Facility size | ft²	17,340
Initial annual base rent	$ 1,200
Escalating rent payments, percent	3.00%
Operating lease right-of-use assets			$ 2,100		$ 2,100		2,800
Lease liabilities			$ 3,200		$ 3,200		$ 3,700
Remaining lease term			3 years		3 years
Incremental borrowing rate			11.18%		11.18%
Security deposit	$ 59

[1] The balance sheet as of December 31, 2022 is derived from the audited financial statements as of that date.