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Significant Accounting Policies, Estimates and Judgments - R&D Expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Schedule Of Asset Acquisition [Line Items]      
Research and development $ 43,250 $ 13,446 $ 5,033
Gilead Asset Purchase      
Schedule Of Asset Acquisition [Line Items]      
Research and development $ 6,600