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Share-Based Compensation - Additional Information (Details) - USD ($)
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Sep. 30, 2024
Sep. 30, 2023
Dec. 31, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Weighted-average remaining contractual life of options, outstanding     5 years 8 months 4 days   6 years 4 months 6 days
Fair value of options, Vested     $ 2,300,000 $ 2,800,000  
Weighted-average grant date fair value of options granted       $ 5.67  
Total share-based compensation $ 6,304,000 $ 7,053,000 19,074,000 $ 20,756,000  
Excess tax benefits in cash flows from operations     0 0  
General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 3,562,000 3,803,000 10,624,000 11,187,000  
Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 2,742,000 3,250,000 $ 8,450,000 9,569,000  
Restricted Share Units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Period expected to realize unrecognized compensation expense     3 years 7 months 6 days    
Total compensation expense not yet recognized relating to unvested RSUs 25,700,000   $ 25,700,000    
Total share-based compensation 3,883,000 3,584,000 $ 11,361,000 10,476,000  
Withheld ordinary shares     377,152   237,859
Taxes withheld on issuance of share-based awards     $ 2,300,000   $ 1,500,000
Restricted Share Units | General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 2,591,000 2,503,000 7,576,000 7,348,000  
Restricted Share Units | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 1,292,000 1,081,000 3,785,000 3,128,000  
Employee Stock Option          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Fair value of options, Vested 2,300,000 2,800,000 $ 9,800,000 $ 12,500,000  
Weighted-average grant date fair value of options granted     $ 3.91 $ 5.67  
Total unvested options compensation expense not yet recognized 10,800,000   $ 10,800,000    
Period expected to realize unrecognized compensation expense     3 years 4 months 24 days    
Total share-based compensation 2,421,000 3,469,000 $ 7,713,000 $ 10,280,000  
Employee Stock Option | Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Contractual term     P10Y    
Employee Stock Option | General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 971,000 1,300,000 $ 3,048,000 3,839,000  
Employee Stock Option | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 1,450,000 2,169,000 4,665,000 6,441,000  
One Participant | General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation $ 100,000   $ 100,000    
Two Participants          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation   40,000.00      
Two Participants | General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation   30,000.00      
Two Participants | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation   $ 10,000.00      
Six Participants          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation       300,000  
Six Participants | General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation       200,000  
Six Participants | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation       $ 100,000  
First Anniversary | Employee Stock Option          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     25.00%    
Vesting period     36 months    
First Anniversary | Directors | Employee Stock Option          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting period     36 months    
Second Anniversary | Restricted Share Units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     50.00%    
Third Anniversary | Restricted Share Units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     25.00%    
Fourth Anniversary | Restricted Share Units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     25.00%