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Share-Based Compensation - Additional Information (Details)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2023
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2023
USD ($)
$ / shares
shares
Jun. 30, 2022
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Weighted-average remaining contractual life of options, outstanding     6 years 11 months 1 day   6 years 10 months 9 days
Fair value of options, Vested $ 3,500 $ 4,200 $ 9,700 $ 11,000  
Weighted-average grant date fair value of options granted | $ / shares     $ 5.71 $ 13.19  
Total share-based compensation 7,271 7,303 $ 13,703 $ 14,881  
Excess tax benefits in cash flows from operations     $ 0 0  
Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Weighted-average remaining contractual life of options, outstanding     10 years    
General and Administrative Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 3,978 3,637 $ 7,384 7,583  
Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 3,293 3,666 $ 6,319 7,298  
Restricted share units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Period expected to realize unrecognized compensation expense     3 years 7 months 6 days    
Total compensation expense not yet recognized relating to unvested RSUs 28,900   $ 28,900    
Total share-based compensation 3,700 3,000 $ 6,900 6,300  
Withheld ordinary shares | shares     179,696   128,812
Taxes withheld on issuance of share-based awards     $ 1,200   $ 2,800
Restricted share units | General and Administrative Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 2,700 2,100 4,900 4,500  
Restricted share units | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 1,000 900 2,000 1,800  
Share Options          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total unvested options compensation expense not yet recognized 25,400   $ 25,400    
Period expected to realize unrecognized compensation expense     3 years 10 months 24 days    
Total share-based compensation 3,600 4,300 $ 6,800 8,600  
Share Options | General and Administrative Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation 1,300 1,500 2,500 3,100  
Share Options | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total share-based compensation $ 2,300 $ 2,800 $ 4,300 $ 5,500  
Director [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting period     36 months    
One Participant Member          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of participants in share-based compensation plan   1   1  
One Participant Member | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation   $ 200   $ 200  
Two Participants Member          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of participants in share-based compensation plan 2   2    
Modifications to share-based compensation $ 200        
Two Participants Member | General and Administrative Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation 200        
Two Participants Member | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation $ 30        
Four Participants Member          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of participants in share-based compensation plan 4   4    
Modifications to share-based compensation     $ 300    
Four Participants Member | General and Administrative Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation     200    
Four Participants Member | Research and Development Expenses          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Modifications to share-based compensation     $ 100    
First Anniversary [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     25.00%    
Second Anniversary [Member] | Restricted share units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     50.00%    
Third Anniversary [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     25.00%    
Fourth Anniversary [Member] | Restricted share units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage     25.00%    
Over Three Years [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting period     36 months