Exhibit 99.21

NOTICE OF ANNUAL AND SPECIAL MEETING OF SHAREHOLDERS

NOTICE IS HEREBY GIVEN that the annual and special meeting of the shareholders (the “Meeting”) of Immunovaccine Inc. (the “Corporation”) will be held at the Innovation Enterprise Centre, 1344 Summer Street, in Halifax, Nova Scotia, Canada, at 12:30 pm AST, on May 10, 2017, for the purposes of:

1. receiving the financial statements of the Corporation for the year ended December 31, 2016 and the report of the auditor thereon;

2. electing directors for the ensuing year;

3. appointing auditor and authorizing the directors to fix its remuneration;

4. adopting a resolution, the text of which is set out in Schedule “A” to the management information circular of the Corporation dated March 31, 2017 (the “Circular”), approving, ratifying and confirming an increase of the number of common shares of the Corporation reserved for issuance under the Corporation’s stock option plan;

5. adopting a resolution, the text of which is set out in Schedule “C” to the Circular, approving, ratifying and confirming the adoption of a deferred share unit (“DSU”) plan by the Corporation (the “DSU Plan”), as more particularly described in the Circular;

6. adopting a resolution, the text of which is set out in Schedule “D” to the Circular, ratifying and confirming the grant of 399,842 DSUs, under the DSU Plan in compliance with the requirements of the Toronto Stock Exchange; and

7. transacting such other business as may properly be brought before the Meeting.

Halifax, Nova Scotia, March 31, 2017

By order of the Board of Directors

(s)Pierre Labbé

Mr. Pierre Labbé

Chief Financial Officer

IMPORTANT

Shareholders may exercise their rights by attending the Meeting or by completing a form of proxy. If you are unable to attend the Meeting in person, please complete, date, and sign the enclosed form of proxy and return it in the envelope provided for that purpose. Proxies, to be valid, must be deposited at the office of the registrar and transfer agent of the Corporation, Computershare Investor Services Inc., 100 University Avenue, 9^th Floor, Toronto, Ontario, M5J 2Y1 no later than 48 hours, excluding Saturdays, Sundays and holidays, prior to the Meeting. Your Shares will be voted in accordance with your instructions as indicated on the form of proxy or, if no instructions are given on the form of proxy, the proxy holder will vote “IN FAVOUR” of each of the matters indicated above.

These security holder materials are being sent to both registered and non-registered owners of the securities. If you are a non-registered owner, and the Corporation or its agent has sent these materials directly to you, your name and address and information about your holdings of securities, have been obtained in accordance with applicable securities regulatory requirements from the intermediary holding your securities on your behalf. By choosing to send these materials to you directly, the Corporation (and not the intermediary holding your securities on your behalf) has assumed responsibility for (i) delivering these materials to you, and (ii) executing your proper voting instructions. Please return your voting instructions as specified in the request for voting instructions. The Corporation or its agent is sending these materials directly to non-registered owners who are “non-objecting beneficial owners” as defined in Canadian securities laws.