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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities:    
Net loss $ (88,208) $ (56,297)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 12,826 5,033
Depreciation and amortization expense 3,367 2,441
Amortization (accretion) of premium (discount) on marketable securities, net 514 88
Loss on sale of property and equipment 223  
Changes in operating assets and liabilities:    
Tenant receivable   448
Prepaid expenses and other current assets 504 (2,870)
Other noncurrent assets (1,021) (169)
Accounts payable 253 (1,321)
Accrued expenses and other current liabilities 523 1,631
Deferred rent   (761)
Net cash used in operating activities (71,019) (51,777)
Cash flows from investing activities:    
Purchases of property and equipment (3,123) (3,724)
Proceeds from sale of property and equipment 105  
Purchases of marketable securities   (221,823)
Maturities of marketable securities 188,900  
Net cash provided by (used in) investing activities 185,882 (225,547)
Cash flows from financing activities:    
Proceeds from issuance of convertible preferred stock, net of issuance costs incurred and paid in current period   108,854
Proceeds from public offering of common stock, net of underwriting discounts and commissions 211,876 213,900
Payment of offering costs (942) (3,185)
Proceeds from exercise of stock options 3,302 1,229
Net cash provided by financing activities 214,236 320,798
Net increase in cash, cash equivalents and restricted cash 329,099 43,474
Cash, cash equivalents and restricted cash at beginning of period 64,940 17,183
Cash, cash equivalents and restricted cash at end of period 394,039 60,657
Supplemental disclosure of noncash investing and financing information:    
Conversion of convertible preferred stock to common stock   224,425
Purchases of property and equipment included in accounts payable and accrued expenses 249 $ 404
Offering costs included in accrued expenses $ 80