Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets
Cash and cash equivalents	$ 65,242	$ 111,973
Marketable securities	136,614	143,705
Prepaid expenses and other current assets	8,557	6,202
Total current assets	210,413	261,880
Property and equipment, net	3,516	3,981
Operating lease right-of-use assets	5,234	5,909
Other assets	743	680
Total assets	219,906	272,450
Current liabilities
Accounts payable	2,731	1,459
Accrued research and development expenses	11,523	15,626
Current portion of long-term debt	11,613	11,613
Accrued expenses and other current liabilities	14,704	20,532
Total current liabilities	40,571	49,230
Long-term convertible senior notes	195,925	195,709
Debt, non-current portion	9,221	11,988
Operating lease liabilities - long-term	2,645	3,446
Total liabilities	248,362	260,373
Commitments and contingencies (Note 9)
Stockholders' equity (deficit)
Common stock, $0.0001 par value; 700,000,000 shares authorized as of March 31, 2023 and December 31, 2022; 95,444,096 shares issued and outstanding as of March 31, 2023, and 94,478,405 shares issued and 94,423,181 shares outstanding as of December 31, 2022	10	10
Additional paid-in capital	1,053,358	1,044,864
Accumulated deficit	(1,081,388)	(1,032,223)
Accumulated other comprehensive loss	(436)	(574)
Total stockholders' equity (deficit)	(28,456)	12,077
Total liabilities and stockholders' equity (deficit)	$ 219,906	$ 272,450