Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Sep. 30, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Long-term convertible senior notes	$ 195,496			$ 150,038
Increase (decrease) in stockholders' equity	56,351	$ (16,461)	$ 30,159	121,463	$ 169,809	$ 220,693	$ 272,084	$ 320,684
Additional paid-in capital
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity	1,033,385	901,141	891,121	932,944	924,914	915,414	907,089	897,607
Accumulated deficit
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity	$ (976,459)	$ (917,096)	$ (860,630)	(811,534)	$ (755,250)	$ (695,003)	$ (635,171)	$ (577,530)
Cumulative Effect, Period of Adoption, Adjustment
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Long-term convertible senior notes				44,800
Write-off of deferred tax liabilities				9,400
Increase (decrease) in stockholders' equity				(44,838)
Cumulative Effect, Period of Adoption, Adjustment | Additional paid-in capital
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity				(53,527)
Cumulative Effect, Period of Adoption, Adjustment | Accumulated deficit
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity				$ 8,689