10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

_________________________

FORM 10-Q

_________________________

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2022

OR

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ________to_________.

Commission File Number: 001-38796

_________________________

GOSSAMER BIO, INC.

(Exact name of Registrant as specified in its charter).

_________________________

Delaware			47-5461709
(State or other jurisdiction of incorporation or organization)			(I.R.S. Employer Identification No.)
3013 Science Park Road	San Diego	California	92121
(Address of principal executive offices)			(Zip Code)

Registrant’s telephone number, including area code: (858) 684-1300

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.0001 par value per share	GOSS	Nasdaq Global Select Market

Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days:    Yes    ☒       No     ☐

Indicate by check mark whether the Registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the Registrant was required to submit such files).    Yes      ☒     No      ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☐
Non-accelerated filer	☒	Smaller reporting company	☒
Emerging growth company	☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.    ☐

1

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).  YES ☐  NO ☒

As of October 31, 2022, the registrant had 94,476,801 shares of common stock ($0.0001 par value) outstanding.

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TABLE OF CONTENTS

PART I. FINANCIAL INFORMATION
	Item 1	Condensed Consolidated Financial Statements (unaudited)	4
		Condensed Consolidated Balance Sheets as of September 30, 2022 (unaudited) and December 31, 2021	4
		Condensed Consolidated Statements of Operations and Comprehensive Loss for the Three and Nine Months ended September 30, 2022 and 2021 (unaudited)	5
		Condensed Consolidated Statements of Stockholders’ Equity (Deficit) for the Nine Months ended September 30, 2022 and 2021 (unaudited)	6
		Condensed Consolidated Statements of Cash Flows for the Nine Months ended September 30, 2022 and 2021 (unaudited)	8
		Notes to Unaudited Condensed Consolidated Financial Statements	9
	Item 2	Management’s Discussion and Analysis of Financial Condition and Results of Operations	22
	Item 3	Quantitative and Qualitative Disclosures About Market Risk	30
	Item 4	Controls and Procedures	30
PART II. OTHER INFORMATION
	Item 1	Legal Proceedings	32
	Item 1A	Risk Factors	32
	Item 2	Unregistered Sales of Equity Securities and Use of Proceeds	32
	Item 3	Defaults Upon Senior Securities	32
	Item 4	Mine Safety Disclosures	32
	Item 5	Other Information	32
	Item 6	Exhibits	32
		Exhibit Index	33
		Signatures	34

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PART I. FINANCIAL INFORMATION

ITEM 1. CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited)

GOSSAMER BIO, INC.

Condensed Consolidated Balance Sheets

(Unaudited)

(in thousands, except share and par value amounts)

	September 30, 2022		December 31, 2021
ASSETS
Current assets
Cash and cash equivalents	$	153,477	$	183,403
Marketable securities	150,906		141,815
Restricted cash	—		64
Prepaid expenses and other current assets	7,649		6,498
Total current assets	312,032		331,780
Property and equipment, net	4,305		5,320
Operating lease right-of-use assets	6,572		5,477
Other assets	629		1,080
Total assets	$	323,538	$	343,657
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities
Accounts payable	$	363	$	3,244
Accrued research and development expenses	20,746		16,205
Accrued expenses and other current liabilities	31,536		20,410
Total current liabilities	52,645		39,859
Long-term convertible senior notes	195,496		150,038
Long-term debt, net of current portion	14,834		29,079
Operating lease liabilities - long-term	4,212		3,218
Total liabilities	267,187		222,194
Commitments and contingencies (Note 9)
Stockholders' equity
Common stock, $0.0001 par value; 700,000,000 shares authorized as of September 30, 2022 and December 31, 2021; 94,135,098 shares issued and 93,914,200 shares outstanding as of September 30, 2022, and 76,470,588 shares issued and 75,752,664 shares outstanding as of December 31, 2021	10		8
Additional paid-in capital	1,033,385		932,944
Accumulated deficit	(976,459)		(811,534)
Accumulated other comprehensive (loss) income	(585)		45
Total stockholders' equity	56,351		121,463
Total liabilities and stockholders' equity	$	323,538	$	343,657

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

4

GOSSAMER BIO, INC.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(Unaudited)

(in thousands, except share and per share amounts)

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Operating expenses:
Research and development	$	44,509	$	43,190	$	129,411	$	129,335
In process research and development	15		15		50		60
General and administrative	11,497		12,459		34,775		35,068
Total operating expenses	56,021		55,664		164,236		164,463
Loss from operations	(56,021)		(55,664)		(164,236)		(164,463)
Other expense
Interest income	465		191		989		525
Interest expense	(3,475)		(4,889)		(10,423)		(14,503)
Other income (expense), net	(332)		115		56		721
Total other expense, net	(3,342)		(4,583)		(9,378)		(13,257)
Net loss	$	(59,363)	$	(60,247)	$	(173,614)	$	(177,720)
Other comprehensive income (loss):
Foreign currency translation	(173)		(64)		(319)		(274)
Unrealized gain (loss) on marketable securities	102		(73)		(311)		(188)
Other comprehensive income (loss)	(71)		(137)		(630)		(462)
Comprehensive loss	(59,434)		(60,384)		(174,244)		(178,182)
Net loss per share, basic and diluted	$	(0.65)	$	(0.80)	$	(2.14)	$	(2.38)
Weighted average common shares outstanding, basic and diluted	91,181,427		75,001,510		81,304,089		74,592,632

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

5

GOSSAMER BIO, INC.

Condensed Consolidated Statements of Stockholders’ Equity (Deficit)

(Unaudited)

(in thousands, except share amounts)

	Common stock			Additional paid-in capital		Accumulated deficit		Accumulated other comprehensive income (loss)		Total stockholders' equity (deficit)
	Shares	Amount
Balance as of December 31, 2021	75,752,664	$	8	$	932,944	$	(811,534)	$	45	$	121,463
Cumulative-effect adjustment from change in accounting principle (See Note 2)	—	—		(53,527)		8,689		—		(44,838)
Vesting of restricted stock	165,675	—		—		—		—		—
Exercise of stock options	39,525	—		126		—		—		126
Stock-based compensation	—	—		10,983		—		—		10,983
Issuance of common stock pursuant to Employee Stock Purchase Plan	77,496	—		595		—		—		595
Issuance of common stock for restricted stock units vested	518,577	—		—		—		—		—
Net loss	—	—		—		(57,785)		—		(57,785)
Other comprehensive loss	—	—		—		—		(385)		(385)
Balance as of March 31, 2022	76,553,937	$	8	$	891,121	$	(860,630)	$	(340)	$	30,159
Vesting of restricted stock	165,675	—		—		—		—		—
Exercise of stock options	8,005	—		21		—		—		21
Stock-based compensation	—	—		9,999		—		—		9,999
Issuance of common stock for restricted stock units vested	8,607	—		—		—		—		—
Net loss	—	—		—		(56,466)		—		(56,466)
Other comprehensive loss	—	—		—		—		(174)		(174)
Balance as of June 30, 2022	76,736,224	$	8	$	901,141	$	(917,096)	$	(514)	$	(16,461)
Issuance of common stock in connection with a private offering, net of offering costs of $184	16,649,365	2		119,926		—		—		119,928
Vesting of restricted stock	165,676	—		—		—		—		—
Exercise of stock options	219,573	—		1,576		—		—		1,576
Stock-based compensation	—	—		10,122		—		—		10,122
Issuance of common stock pursuant to Employee Stock Purchase Plan	80,362	—		620		—		—		620
Issuance of common stock for restricted stock units vested	63,000	—		—		—		—		—
Net loss	—	—		—		(59,363)		—		(59,363)
Other comprehensive loss	—	—		—		—		(71)		(71)
Balance as of September 30, 2022	93,914,200	$	10	$	1,033,385	$	(976,459)	$	(585)	$	56,351

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	Common stock			Additional paid-in capital		Accumulated deficit		Accumulated other comprehensive income (loss)		Total stockholders' equity
	Shares	Amount
Balance as of December 31, 2020	73,874,904	$	8	$	897,607	$	(577,530)	$	599	$	320,684
Vesting of restricted stock	238,962	—		—		—		—		—
Exercise of stock options	5,721	—		15		—		—		15
Stock-based compensation	—	—		8,708		—		—		8,708
Issuance of common stock pursuant to Employee Stock Purchase Plan	95,004	—		759		—		—		759
Issuance of common stock for restricted stock units vested	278,559	—		—		—		—		—
Net loss	—	—		—		(57,641)		—		(57,641)
Other comprehensive loss	—	—		—		—		(441)		(441)
Balance as of March 31, 2021	74,493,150	$	8	$	907,089	$	(635,171)	$	158	$	272,084
Vesting of restricted stock	231,710	—		—		—		—		—
Exercise of stock options	103,922	—		271		—		—		271
Stock-based compensation	—	—		8,054		—		—		8,054
Issuance of common stock for restricted stock units vested	6,170	—		—		—		—		—
Net loss	—	—		—		(59,832)		—		(59,832)
Other comprehensive income	—	—		—		—		116		116
Balance as of June 30, 2021	74,834,952	$	8	$	915,414	$	(695,003)	$	274	$	220,693
Vesting of restricted stock	228,084	—		—		—		—		—
Exercise of stock options	171,252	—		1,357		—		—		1,357
Stock-based compensation	—	—		7,587		—		—		7,587
Issuance of common stock pursuant to Employee Stock Purchase Plan	65,786	—		556		—		—		556
Net loss	—	—		—		(60,247)		—		(60,247)
Other comprehensive loss	—	—		—		—		(137)		(137)
Balance as of September 30, 2021	75,300,074	$	8	$	924,914	$	(755,250)	$	137	$	169,809

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

7

GOSSAMER BIO, INC.

Condensed Consolidated Statements of Cash Flows

(Unaudited)

(in thousands)

	Nine months ended September 30,
	2022		2021
Cash flows from operating activities
Net loss	$	(173,614)	$	(177,720)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	1,372		1,292
Stock-based compensation expense	31,104		24,349
In process research and development expenses	50		60
Amortization of operating lease right-of-use assets	1,934		2,593
Amortization of long-term debt discount and issuance costs	893		4,983
Amortization of premium (discount) on marketable securities, net of accretion of discounts	(261)		186
Loss on disposal of property and equipment	—		84
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(1,151)		1,221
Other assets	451		(87)
Operating lease liabilities	(2,030)		(2,706)
Accounts payable	(2,098)		(6,808)
Accrued expenses	(1,561)		4,715
Accrued research and development expenses	4,541		3,375
Accrued compensation and benefits	(1,415)		(3,918)
Accrued interest expense	2,483		—
Net cash used in operating activities	(139,302)		(148,381)
Cash flows from investing activities
Research and development asset acquisitions, net of cash acquired	(50)		(60)
Purchase of marketable securities	(160,641)		(143,897)
Maturities of marketable securities	151,500		17,550
Purchase of property and equipment	(308)		(1,463)
Net cash used in investing activities	(9,499)		(127,870)
Cash flows from financing activities
Proceeds from issuance of common stock in a private offering, net of offering costs	119,928		—
Proceeds from issuance of common stock pursuant to Employee Stock Purchase Plan	1,215		1,315
Proceeds from the exercise of stock options	1,723		1,643
Principal repayments of long-term debt	(2,903)		—
Net cash provided by financing activities	119,963		2,958
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(1,152)		211
Net decrease in cash, cash equivalents and restricted cash	(29,990)		(273,082)
Cash, cash equivalents and restricted cash, at the beginning of the period	183,467		486,620
Cash, cash equivalents and restricted cash, at the end of the period	$	153,477	$	213,538
Supplemental disclosure of cash flow information:
Cash paid for interest	$	7,042	$	7,055
Supplemental disclosure of noncash investing and financing activities:
Operating lease right-of-use asset obtained in exchange for lease liability	$	3,029	$	—
Derecognition ROU lease assets obtained in exchange for operating lease liabilities	$	—	$	1,650
Change in unrealized gain (loss) on marketable securities, net	$	(311)	$	188
Purchases of property and equipment included in accounts payable and accrued expenses and other current liabilities	$	49	$	—

The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.

8

GOSSAMER BIO, INC.

Notes to Unaudited Condensed Consolidated Financial Statements

Note 1 - Description of the Business

Gossamer Bio, Inc. (including its subsidiaries, referred to as “we,” “us,” “our,”, or the “Company”) is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology. The Company was incorporated in the state of Delaware on October 25, 2015 (originally as FSG Bio, Inc.) and is based in San Diego, California.

The unaudited condensed consolidated financial statements include the accounts of Gossamer Bio, Inc. and its wholly owned subsidiaries. All intercompany balances and transactions among the consolidated entity have been eliminated in consolidation.

Liquidity and Capital Resources

The Company has incurred significant operating losses since its inception. As of September 30, 2022, the Company had an accumulated deficit of $976.5 million. From the Company’s inception through September 30, 2022, the Company has funded its operations primarily through equity and debt financings. The Company raised $1,062.1 million from October 2017 through September 30, 2022 through the sale of Series A and B convertible preferred stock, issuance of convertible notes, its initial public offering ("IPO"), the Credit Facility and 2027 Notes (as defined in Note 5 below), and issuances of common stock in May 2020 and July 2022. See Note 5 for additional information regarding the Credit Facility and the 2027 Notes.

The Company expects to continue to incur significant operating losses for the foreseeable future and may never become profitable. As a result, the Company will need to raise additional capital through equity offerings, debt financings or other capital sources, including potential collaborations, licenses and other similar arrangements. Management believes that it has sufficient working capital on hand to fund operations through at least the next 12 months from the date these condensed consolidated financial statements were available to be issued. There can be no assurance that the Company will be successful in acquiring additional funding, that the Company’s projections of its future working capital needs will prove accurate, or that any additional funding would be sufficient to continue operations in future years.

COVID-19

The COVID-19 pandemic has caused significant business disruption around the globe. The extent of the impact of COVID-19 on the Company’s operational and financial performance will depend on certain developments, including the duration and spread of the pandemic worldwide and the impact on the Company’s clinical trials, employees and vendors. To the extent possible, and consistent with applicable guidance from federal, state and local authorities, the Company is conducting business as usual. The Company will continue to actively monitor the evolving situation related to COVID-19 and may take further actions that alter its operations, including those that may be required by federal, state or local authorities, or that the Company determines are in the best interests of its employees and other third parties with whom the Company does business. At this point, the degree to which COVID-19, including new variants of the virus that causes COVID-19, may continue to impact the Company’s financial condition or results of operations remains uncertain. A prolonged pandemic could have a material and adverse impact on the financial results and business operations of the Company, including the timing and ability of the Company to complete certain clinical trials and other efforts required to advance the development of its product candidates and raise additional capital. For example, certain sites temporarily closed enrollment in the Company's Phase 2 clinical trial in pulmonary arterial hypertension ("PAH") in 2020 as a result of the COVID-19 pandemic and related staffing shortages at sites and key vendors. In addition, due to the challenges of enrolling patients worldwide posed by the COVID-19 pandemic and related staffing shortages at sites and key vendors, the Company previously experienced delays in enrollment of patients in its Phase 2 clinical trial of seralutinib, also known as GB002, in PAH.

9

Note 2 - Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) for interim financial information and with the instructions of the Securities and Exchange Commission (“SEC”) on Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and disclosures required by GAAP for complete financial statements. In the opinion of management, the condensed consolidated financial statements include all adjustments necessary, which are of a normal and recurring nature, for the fair presentation of the Company’s financial position and of the results of operations and cash flows for the periods presented. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto for the year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 3, 2022. The results of operations for the interim period shown in this report are not necessarily indicative of the results that may be expected for any other interim period or for the full year. The balance sheet at December 31, 2021, has been derived from the audited financial statements at that date.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of expenses during the reporting period. The most significant estimates in the Company’s condensed consolidated financial statements relate to the allocation of the 2027 Notes into liability and equity components and accrued research and development expenses. These estimates and assumptions are based on current facts, historical experience and various other factors believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities and the recording of expenses that are not readily apparent from other sources. Actual results could differ from those estimates.

Recent Accounting Pronouncements - Adopted

In August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2020-06, Debt: Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity's Own Equity (Subtopic 815-40) (“ASU 2020-06”), which simplifies the accounting for convertible instruments and contracts in an entity's own equity. This guidance is effective for annual reporting periods beginning after December 15, 2021, including interim periods within those years, with early adoption permitted only as of annual reporting periods beginning after December 15, 2020.

The Company adopted ASU 2020-06 on January 1, 2022 using the modified retrospective approach, and accordingly the Company recorded an adjustment that reflects the 2027 Notes as if the embedded conversion feature had not been separated. The impact upon adoption on the Consolidated Balance Sheets was an increase of $44.8 million in convertible senior notes, net, a write-off of $9.4 million in deferred income tax liabilities and a decrease of $53.5 million in additional paid-in capital. In addition, upon adoption, there was an adjustment of $8.7 million to increase the beginning balance of accumulated deficit on the Consolidated Balance Sheets for previously recognized interest expense related to amortization of debt discount related to the carrying value of the embedded conversion feature upon issuance. There was no impact to the Company’s net loss per share calculation. See Note 5 "Indebtedness" for further information regarding the 2027 Notes.

Net Loss Per Share

Basic net loss per share of common stock is computed by dividing net loss attributable to common stockholders by the weighted average number of shares of common stock outstanding for the period. The Company uses the if-converted method for assumed conversion of the 2027 Notes to compute the weighted average shares of common stock outstanding for diluted net loss per share. Diluted net loss per share excludes the potential impact of the Company’s common stock options and unvested shares of restricted stock and the potential shares issuable upon conversion of the 2027 Notes because their effect would be anti-dilutive due to the Company’s net loss. Since the Company had a net loss in each of the periods presented, basic and diluted net loss per common share are the same.

The table below provides potentially dilutive securities not included in the calculation of the diluted net loss per share because to do so would be anti-dilutive:

10

	As of September 30,
	2022	2021
2027 Notes	12,321,900	12,321,900
Shares issuable upon exercise of stock options	12,789,376	9,540,332
Non-vested shares under restricted stock grants	1,856,688	3,020,509
Total potentially dilutive securities	26,967,964	24,882,741

Note 3 - Balance Sheet Accounts and Supplemental Disclosures

Property and Equipment

Property and equipment, net consisted of the following (in thousands):

	Estimated Useful Life (in years)	September 30, 2022		December 31, 2021
Office equipment	3-7	$	1,097	$	1,097
Computer equipment	5	123		123
Software	3	130		130
Lab equipment	2-5	6,044		5,688
Leasehold improvements	6-7	2,562		2,562
Total property and equipment		9,956		9,600
Less: accumulated depreciation		5,651		4,280
Property and equipment, net		$	4,305	$	5,320

For each of the three months ended September 30, 2022 and 2021 the Company recorded approximately $0.5 million in depreciation expense, and for the nine months ended September 30, 2022 and 2021, the Company recorded approximately $1.4 million and $1.3 million, respectively, in depreciation expense, in each case, which is included in general and administrative expense and research and development expense on the consolidated statements of operations and comprehensive loss.

Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):

	As of
	September 30, 2022		December 31, 2021
Accrued compensation and benefits	$	10,501	$	11,916
Operating lease liabilities	2,907		2,902
Debt, current	11,613		—
Accrued consulting fees	1,433		956
Accrued interest	3,549		1,066
Accrued legal fees	251		202
Accrued litigation liability	—		2,375
Accrued accounting fees	429		154
Accrued other	853		839
Total accrued expenses and other current liabilities	$	31,536	$	20,410

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Note 4 - Fair Value Measurements and Available for Sale Investments

Fair Value Measurements

The accounting guidance defines fair value, establishes a consistent framework for measuring fair value and expands disclosure for each major asset and liability category measured at fair value on either a recurring or nonrecurring basis. Fair value is defined as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumptions, the accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:

Level 1: Observable inputs such as quoted prices in active markets;

Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and

Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions.

The Company classifies its cash equivalents and available-for-sale investments within Level 1 or Level 2. The fair value of the Company’s investment grade corporate debt securities and commercial paper is determined using proprietary valuation models and analytical tools, which utilize market pricing or prices for similar instruments that are both objective and publicly available, such as matrix pricing or reported trades, benchmark yields, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, and offers.

Assets and Liabilities Measured at Fair Value on a Recurring Basis

The following table presents the hierarchy for assets measured at fair value on a recurring basis as of September 30, 2022 and December 31, 2021 (in thousands):

	Fair Value Measurements at End of Period Using:
	Total Fair Value		Quoted Market Prices for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
As of September 30, 2022
Money market funds	$	81,850	$	81,850	$	—	$	—
U.S. Treasury and agency securities	58,883		58,883		—		—
Commercial paper	119,603		—		119,603		—
Corporate debt securities	12,347		—		12,347		—
As of December 31, 2021
Money market funds	$	139,794	$	139,794	$	—	$	—
Commercial paper	113,939		—		113,939		—
Corporate debt securities	37,873		—		37,873		—

The Company did not reclassify any investments between levels in the fair value hierarchy during the periods presented.

Fair Value of Other Financial Instruments

As of September 30, 2022 and December 31, 2021, the carrying amounts of the Company’s financial instruments, which include cash, restricted cash, prepaid and other current assets, interest receivable, accrued research and development expenses, accounts payable and accrued expenses and other current liabilities, approximate fair values because of their short maturities.

Interest receivable as of September 30, 2022 and December 31, 2021, was $0.1 million and $0.2 million, respectively, and is recorded as a component of prepaid expenses and other current assets on the condensed consolidated balance sheets.

The Company believes that its Credit Facility bears interest at a rate that approximates prevailing market rates for instruments with similar characteristics and, accordingly, the carrying value of the Credit Facility approximates fair value. The Company estimates the fair value of long-term debt utilizing an income approach. The Company uses a present value calculation to discount principal and interest payments and the final maturity payment on these liabilities using a discounted cash flow model based on observable inputs. The debt instrument is then discounted based on what the current market rates

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would be as of the reporting date. Based on the assumptions used to value these liabilities at fair value, the debt instrument is categorized as Level 2 in the fair value hierarchy.

As of September 30, 2022 and December 31, 2021, the fair value of the Company’s 2027 Notes was $227.5 million and $190.5 million, respectively. The fair value was determined on the basis of market prices observable for similar instruments and is considered Level 2 in the fair value hierarchy (see Note 5).

Available for Sale Investments

The Company invests its excess cash in U.S. Treasury and agency securities, corporate debt securities, and commercial paper, which are classified as available-for-sale investments. These investments are carried at fair value and are included in the tables below. The Company evaluates securities with unrealized losses to determine whether such losses, if any, are due to credit-related factors. Realized gains and losses are calculated using the specific identification method and recorded in other income (expense) in the Company's condensed consolidated statement of operations and comprehensive loss. The Company does not intend to sell the investments and it is not more likely than not that the Company will be required to sell the investments before recover of their amortized cost basis.

The aggregate market value, cost basis, and gross unrealized losses of available-for-sale investments by security type, classified in marketable securities and long-term investments as of September 30, 2022 and December 31, 2021 are as follows (in thousands):

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Total Fair Value
As of September 30, 2022
U.S. Treasury and agency securities	$	41,494	$	—	$	(79)	$	41,415
Corporate debt securities	12,426		—		(79)		12,347
Commercial paper	97,345		—		(201)		97,144
Total marketable securities	$	151,265	$	—	$	(359)	$	150,906
As of December 31, 2021
Corporate debt securities	$	37,921	$	—	$	(48)	$	37,873
Commercial paper	103,942		—		—		103,942
Total marketable securities	$	141,863	$	—	$	(48)	$	141,815

As of September 30, 2022 and December 31, 2021, the Company classified $39.9 million and $10.0 million, respectively, of assets with original maturities of 90 days or less as cash and cash equivalents.

At each reporting date, the Company performs an evaluation of impairment to determine if any unrealized losses are due to credit-related factors. The Company records an allowance for credit losses when unrealized losses are due to credit-related factors. Factors considered when evaluating available-for-sale investments for impairment include the severity of the impairment, changes in underlying credit ratings, the financial condition of the issuer, the probability that the scheduled cash payments will continue to be made and the Company’s intent and ability to hold the investment until recovery of the amortized cost basis. The Company intends and has the ability to hold its investments in unrealized loss positions until their amortized cost basis has been recovered. As of September 30, 2022 and December 31, 2021, there were no material declines in the market value of the Company’s available-for-sale investments due to credit-related factors.

Contractual maturities of available-for-sale debt securities, as of September 30, 2022, were as follows (in thousands):

	Estimated  Fair Value
Less than one year	$	150,906
Greater than one year	—
Total	$	150,906

The Company has the ability, if necessary, to liquidate any of its cash equivalents and marketable securities to meet its liquidity needs in the next 12 months.

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Note 5 - Indebtedness

Credit Facility

On May 2, 2019, the Company entered into a credit, guaranty and security agreement, as amended on September 18, 2019 and July 2, 2020 (the “Credit Facility”), with MidCap Financial Trust (“MidCap”), as agent and lender, and the additional lenders party thereto from time to time (together with MidCap, the “Lenders”), pursuant to which the Lenders, including affiliates of MidCap and Silicon Valley Bank, agreed to make term loans available to the Company for working capital and general business purposes, in a principal amount of up to $150.0 million in term loan commitments, including a $30.0 million term loan that was funded at the closing date, with the ability to access the remaining $120.0 million in two additional tranches (each $60.0 million), subject to specified availability periods, the achievement of certain clinical development milestones, minimum cash requirements and other customary conditions. The Company did not achieve the clinical development milestone required to access one of the $60.0 million tranches. The Company, GB001, Inc., GB002, Inc., and GB004, Inc., each wholly-owned subsidiaries of the Company, are designated as co-borrowers to the Credit Facility, whereas GB003, Inc., GB005, Inc., GB006, Inc., GB007, Inc., GB008, Inc. and Gossamer Bio Services, Inc., each wholly-owned subsidiaries of the Company, are designated as guarantors. The remaining tranche is available no earlier than the satisfaction of the applicable funding conditions, including the applicable clinical development milestone, and no later than December 31, 2022. As of September 30, 2022, no tranches under the Credit Facility were available to be drawn. The Credit Facility is secured by substantially all of the Company’s and its domestic subsidiaries’ personal property, including intellectual property.

Each term loan under the Credit Facility bears interest at an annual rate equal to the sum of (i) one-month LIBOR (customarily defined, with a change to prime rate if LIBOR funding becomes unlawful or impractical) plus (ii) 7.00%, subject to a LIBOR floor of 2.00%. The borrower is required to make interest-only payments on the term loan for all payment dates prior to July 1, 2022.  The term loans under the Credit Facility began amortizing on July 1, 2022, with equal monthly payments of principal plus interest being made by the Company to the Lenders in consecutive monthly installments following such interest-only period until the Credit Facility matures on January 1, 2025. Upon final repayment of the term loans, the borrower must pay an exit fee of 1.75% of the amount borrowed under the Credit Facility, less any partial exit fees previously paid. Upon partial prepayment of a portion of the term loans, the borrower must pay a partial exit fee of 1.75% of the principal being prepaid. At the borrower’s option, the borrower may prepay the outstanding principal balance of the term loan in whole or in part, subject to a prepayment fee of 3.00% of any amount prepaid if the prepayment occurs through and including the first anniversary of the second amendment effective date, 2.00% of the amount prepaid if the prepayment occurs after the first anniversary of the second amendment effective date through and including the second anniversary of the second amendment effective date, and 1.00% of any amount prepaid after the second anniversary of the second amendment effective date and prior to January 1, 2025.

The Credit Facility includes affirmative and negative covenants applicable to the Company and certain of its subsidiaries. The affirmative covenants include, among others, covenants requiring such entities to maintain their legal existence and governmental approvals, deliver certain financial reports, maintain insurance coverage, maintain property, pay taxes, satisfy certain requirements regarding accounts and comply with laws and regulations.  The negative covenants include, among others, restrictions on such entities from transferring collateral, incurring additional indebtedness, engaging in mergers or acquisitions, paying dividends or making other distributions, making investments, creating liens, amending material agreements and organizational documents, selling assets and suffering a change in control, in each case subject to certain exceptions. The Company and certain of its subsidiaries are also subject to an ongoing minimum cash financial covenant in which they must maintain unrestricted cash in an amount not less than 25% of the outstanding principal amount of the term loans. As of September 30, 2022, the Company was in compliance with these covenants.

The Credit Facility also includes events of default, the occurrence and continuation of which could cause interest to be charged at the rate that is otherwise applicable plus 3.00% and would provide MidCap, as agent, with the right to exercise remedies against the Company and/or certain of its subsidiaries, and the collateral securing the Credit Facility, including foreclosure against the properties securing the credit facilities, including cash. These events of default include, among other things, failure to pay any amounts due under the Credit Facility, a breach of covenants under the Credit Facility, insolvency or the occurrence of insolvency events, the occurrence of a change in control, the occurrence of certain U.S. Food and Drug Administration (“FDA”) and regulatory events, failure to remain registered with the SEC and listed for trading on Nasdaq, the occurrence of a material adverse change, the occurrence of a default under a material agreement reasonably expected to result in a material adverse change, the occurrence of certain defaults under certain other indebtedness in an amount greater than $2.5 million and the occurrence of certain defaults under subordinated indebtedness and convertible indebtedness.

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Debt consisted of the following (in thousands):

	September 30, 2022		December 31, 2021
Debt, current portion	$	11,613	$	—
Debt, non-current portion	15,484		30,000
Total debt	27,097		30,000
Less: unamortized debt discount and issuance costs	(650)		(921)
Debt, net	$	26,447	$	29,079

The scheduled future minimum principal payments are as follows (in thousands):

	September 30, 2022
2022 (remaining 3 months)	$	2,903
2023	11,613
2024	11,613
2025	968
Total	$	27,097

5.00% Convertible Senior Notes due 2027

On May 21, 2020, the Company issued $200.0 million aggregate principal amount of 5.00% convertible senior notes due 2027 in a public offering (the "2027 Notes"). The 2027 Notes were registered pursuant to the Company’s shelf registration statement on Form S-3 filed with the SEC on April 10, 2020. The interest rate on the 2027 Notes is fixed at 5.00% per annum. Interest is payable semi-annually in arrears on June 1 and December 1 of each year, commencing on December 1, 2020. The 2027 Notes will mature on June 1, 2027. The net proceeds from the offering, after deducting the underwriting discounts and commissions and other offering costs, were approximately $193.6 million. The 2027 Notes may be settled in cash, shares of the Company’s common stock, or a combination thereof, solely at the Company’s election. The initial conversion rate of the 2027 Notes is 61.6095 shares per $1,000 principal amount, which is equivalent to a conversion price of approximately $16.23 per share, subject to adjustments. In addition, following certain corporate events that occur prior to the maturity date or if the Company issues a notice of redemption, the Company will increase the conversion rate for a holder who elects to convert its 2027 Notes in connection with such a corporate event during the related redemption period in certain circumstances. 

The 2027 Notes are senior unsecured obligations of the Company, ranking senior in right of payment to any of the Company’s indebtedness that is expressly subordinated in right of payment to the 2027 Notes, and are effectively subordinated to the Company’s existing and future secured indebtedness, to the extent of the value of the collateral securing that indebtedness, including all indebtedness under the Credit Facility.

Holders may convert their notes at their option only in the following circumstances: (1) during any calendar quarter (and only during such calendar quarter) commencing after the calendar quarter ending on September 30, 2020, if the last reported sale price per share of the Company’s common stock exceeds 130% of the conversion price for each of at least 20 trading days (whether or not consecutive) during the 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter; (2) during the five consecutive business days immediately after any 10 consecutive trading day period (such 10 consecutive trading day period, the “measurement period”) in which the trading price per $1,000 principal amount of notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price per share of the Company’s common stock on such trading day and the conversion rate on such trading day; (3) upon the occurrence of certain corporate events or distributions on the Company’s common stock; (4) if the Company calls such notes for redemption; and (5) at any time from, and including, March 1, 2027 until the close of business on the scheduled trading day immediately before the maturity date.

The Company will not have the right to redeem the 2027 Notes prior to June 6, 2024. On or after June 6, 2024 and on or before the 50th scheduled trading day immediately before the maturity date, the Company may redeem the 2027 Notes, in whole or in part, if the last reported sale price of the Company’s common stock has been at least 130% of the conversion price then in effect on (1) each of at least 20 trading days (whether or not consecutive) during the 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related redemption notice; and (2) the trading day immediately before the date the Company sends such notice. In the case of any optional redemption, the Company

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will redeem the 2027 Notes at a redemption price equal to 100% of the principal amount of such Notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date.

If the Company undergoes a fundamental change prior to the maturity date of the 2027 Notes, holders of the 2027 Notes may require the Company to repurchase for cash all or part of their 2027 Notes at a repurchase price equal to 100% of the principal amount of the 2027 Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date.

The indenture governing the 2027 Notes provides for customary terms and covenants, including that upon certain events of default, either the trustee or the holders of not less than 25% in aggregate principal amount of the 2027 Notes then outstanding may declare the unpaid principal amount of the 2027 Notes and accrued and unpaid interest, if any, thereon immediately due and payable. As of September 30, 2022, the Company was in compliance with these covenants. In the case of certain events of bankruptcy, insolvency or reorganization, the principal amount of the 2027 Notes together with accrued and unpaid interest, if any, thereon will automatically become and be immediately due and payable.

As of September 30, 2022, there were no events or market conditions that would allow holders to convert the 2027 Notes. When the 2027 Notes become convertible within 12 months of the balance sheet date, the carrying value of the 2027 Notes will be reclassified to short-term.

In accounting for the issuance of the 2027 Notes prior to the adoption of ASU 2020-06, the Company separated the 2027 Notes into liability and equity components. The carrying amount of the liability component was calculated by measuring the fair value of similar debt instruments that do not have associated convertible features. The carrying amount of the equity component representing the conversion option was $53.5 million and was determined by deducting the fair value of the liability component from the par value of the 2027 Notes. The equity component is not remeasured as long as it continues to meet the conditions for equity classification. The debt discount is amortized to interest expense over the term of the 2027 Notes at an effective interest rate of 11.17% over the contractual terms of the 2027 Notes.

In accounting for the debt issuance costs of $0.4 million related to the 2027 Notes, the Company allocated the total amount incurred to the liability and equity components of the 2027 Notes based on their relative fair values. Issuance costs attributable to the liability component were $0.3 million and were amortized to interest expense using the effective interest method over the contractual terms of the 2027 Notes. Issuance costs attributable to the equity component were netted with the equity component in stockholders’ equity. As of January 1, 2022 the Company adopted ASU 2020-06, see Note 2 for the impact upon adoption to the 2027 Notes.

The net carrying amount of the liability component of the 2027 Notes was as follows (in thousands):

	September 30, 2022		December 31, 2021
Principal amount	$	200,000	$	200,000
Unamortized debt discount	(4,220)		(49,716)
Unamortized debt issuance cost	(284)		(246)
Net carrying amount	$	195,496	$	150,038

The net carrying amount of the equity component of the 2027 Notes was as follows (in thousands):

	September 30, 2022		December 31, 2021
Debt discount related to the value of conversion option	$	—	$	53,635
Debt issuance cost	—		(109)
Net carrying amount	$	—	$	53,526

The following table sets forth the interest expense recognized related to the 2027 Notes (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Contractual interest expense	$	2,500	$	2,500	$	7,500	$	7,472
Amortization of debt discount	197		1,606		582		4,713
Amortization of debt issuance cost	13		7		39		23
Total interest expense related to the 2027 Notes	$	2,710	$	4,113	$	8,121	$	12,208

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Note 6 - Licenses, Asset Acquisitions and Contingent Consideration

The following purchased assets were accounted for as asset acquisitions as substantially all of the fair value of the assets acquired were concentrated in a group of similar assets and/or the acquired assets were not capable of producing outputs due to the lack of employees and early stage of development. Because the assets had not yet received regulatory approval, the fair value attributable to these assets was recorded as in process research and development (“IPR&D”) expenses in the Company’s condensed consolidated statement of operations for the three and nine months ended September 30, 2022.

The Company accounts for contingent consideration payable upon achievement of certain regulatory, development or sales milestones in such asset acquisitions when the underlying contingency is met.

License from Pulmokine, Inc. (Seralutinib)

On October 2, 2017, the Company entered into a license agreement with Pulmokine, Inc. under which it was granted an exclusive worldwide license and sublicense to certain intellectual property rights owned or controlled by Pulmokine to develop and commercialize seralutinib and certain backup compounds for the treatment, prevention and diagnosis of any and all diseases or conditions. The Company also has the right to sublicense its rights under the license agreement, subject to certain conditions. The assets acquired are in the early stages of the FDA approval process, and the Company intends to further develop the assets acquired through potential FDA approval as evidenced by the milestone arrangement in the contract. The development activities cannot be performed without significant cost and effort by the Company. The agreement will remain in effect from the effective date, unless terminated earlier, until, on a licensed product-by-licensed product and country-by-country basis, the later of ten years from the date of first commercial sale or when there is no longer a valid patent claim covering such licensed product or specified regulatory exclusivity for the licensed product in such country. The Company is obligated to make future development and regulatory milestone payments of up to $58.0 million, commercial milestone payments of up to $45.0 million, and sales milestone payments of up to $190.0 million. The Company is also obligated to pay tiered royalties on sales for each licensed product, at percentages ranging from the mid-single digits to the high single-digits. In addition, if the Company chooses to sublicense or assign to any third parties its rights under the agreement with respect to a licensed product, or the Company’s seralutinib operating subsidiary undergoes a change of control, the Company must pay to Pulmokine a specified percentage of all revenue to be received in connection with such transaction. The Company made an upfront payment of $5.5 million in October 2017. In December 2020, the Company accrued a milestone payment of $5.0 million in connection with the initiation of the first Phase 2 clinical trial of seralutinib, which was paid in January 2021. As of September 30, 2022, no other milestones had been accrued as the underlying contingencies had not yet been met.

License from Aadi Biosciences, Inc. (GB004)

On June 24, 2018, the Company entered into a license agreement with Aerpio Pharmaceuticals, Inc., now known as Aadi Biosciences, Inc. ("Aadi"), under which the Company was granted an exclusive worldwide license and sublicense to certain intellectual property rights owned or controlled by Aadi to develop and commercialize GB004, and certain other related compounds for all applications. On July 24, 2022, the license agreement was terminated. As of September 30, 2022, no milestones had been accrued as the underlying contingencies had not yet been met.

Note 7 - Stockholders’ Equity

Common Stock

Each share of common stock is entitled to one vote. Common stock owners are entitled to dividends when funds are legally available and declared by the Board.

Private Placement Financing

On July 15, 2022, we completed a private placement of 16,649,365 shares of our common stock at purchase price of $7.21 per share. The gross proceeds for the private placement were approximately $120.1 million, before deducting offering expenses. On August 9, 2022, we filed a registration statement on Form S-3 registering the shares of common stock issued in the private placement, which registration statement became automatically effective on August 9, 2022.

Shares of Common Stock Subject to Repurchase

On December 3, 2015, the Company issued 9,160,888 shares of common stock as founder shares for services rendered to the Company, valued at $0.0001 par value per share, for a total of approximately $4,100 (the "founder shares"). On January 4,

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2018, incremental vesting conditions were placed on the previously issued founder shares. Fifty percent of the previously issued founder shares vested on January 4, 2018, and the remaining founder shares are subject to vesting restrictions over a period of five years. These shares are subject to repurchase by the Company upon a founder's termination of employment or service to the Company.

Pursuant to the employment agreements with the Company’s founders executed January 4, 2018, the Company provided for certain potential additional issuances of common stock (the “anti-dilution shares”) to each of the founders to ensure the total number of shares of common stock held by them and their affiliates (inclusive of any shares subject to equity awards granted by the Company) would represent 15% of the Company’s fully-diluted capitalization until such time as the Company raised $300.0 million in equity capital, including the capital raised in the Series A financing.

In furtherance of this obligation, on May 21, 2018, the Company issued 251,547 shares of common stock to the founders for services rendered to the Company, valued at $2.61 per share with an additional 251,547 shares of restricted stock subject to the same vesting restrictions and vesting period as the founder shares. In addition, on September 6, 2018, the Company issued 1,795,023 shares of common stock to the founders for services rendered to the Company, valued at $9.63 per share, with an additional 1,795,023 shares of restricted stock subject to the same vesting restrictions and vesting period as the founder shares.

During the nine months ended September 30, 2022, no shares were forfeited due to termination of employment. During the year ended December 31, 2021, 25,383 shares were forfeited due to termination of employment. Any shares subject to repurchase by the Company are not deemed, for accounting purposes, to be outstanding until those shares vest. As such, the Company recognizes the measurement date fair value of the restricted stock over the vesting period as compensation expense. As of September 30, 2022 and December 31, 2021, 220,902 and 717,927 shares of common stock, respectively, were subject to repurchase by the Company. The unvested stock liability related to these awards is immaterial to all periods presented.

Note 8 - Equity Incentive Plans

2019 Equity Incentive Plan

In January 2019, the Company’s board of directors and stockholders approved and adopted the 2019 Incentive Award Plan (the “2019 Plan”). The 2019 Plan became effective on February 6, 2019, the day prior to the effectiveness of the registration statement filed in connection with the IPO. Under the 2019 Plan, the Company may grant stock options, stock appreciation rights, restricted stock, restricted stock units, and other stock or cash-based awards to individuals who are then employees, officers, directors or consultants of the Company, and employees and consultants of the Company’s subsidiaries. A total of 5,750,000 shares of common stock were approved to be initially reserved for issuance under the 2019 Plan. The number of shares that remained available for issuance under the 2017 Plan (as defined below) as of the effective date of the 2019 Plan were, and shares subject to outstanding awards under the 2017 Plan as of the effective date of the 2019 Plan that are subsequently canceled, forfeited or repurchased by the Company will be, added to the shares reserved under the 2019 Plan. In addition, the number of shares of common stock available for issuance under the 2019 Plan will be automatically increased on the first day of each calendar year during the ten-year term of the 2019 Plan, beginning with January 1, 2020 and ending with January 1, 2029, by an amount equal to 5% of the outstanding number of shares of the Company’s common stock on December 31 of the preceding calendar year or such lesser amount as determined by the Company’s board of directors. As of September 30, 2022, an aggregate of 5,189,165 shares of common stock were available for issuance under the 2019 Plan. As of September 30, 2022 and December 31, 2021, 11,810,964 and 8,402,621 shares of common stock, respectively, were subject to outstanding awards under the 2019 Plan.

2019 Employee Stock Purchase Plan

In January 2019, the Company’s board of directors and stockholders approved and adopted the 2019 Employee Stock Purchase Plan (the “ESPP”). The ESPP became effective as of February 6, 2019, the day prior to the effectiveness of the registration statement filed in connection with the IPO. The ESPP permits participants to purchase common stock through payroll deductions of up to 20% of their eligible compensation. A total of 700,000 shares of common stock were approved to be initially reserved for issuance under the ESPP. In addition, the number of shares of common stock available for issuance under the ESPP will be automatically increased on the first day of each calendar year during the first ten years of the term of the ESPP, beginning with January 1, 2020 and ending with January 1, 2029, by an amount equal to 1% of the outstanding number of shares of the Company’s common stock on December 31 of the preceding calendar year or such lesser amount as determined by the Company’s board of directors. During the nine months ended September 30, 2022, 157,858 shares were issued pursuant to the ESPP. As of September 30, 2022, an aggregate of 2,450,855 shares of common stock were available for issuance under the ESPP.

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2017 Equity Incentive Plan

The Company’s 2017 Equity Incentive Plan (the “2017 Plan”) permitted the granting of incentive stock options, non-statutory stock options, restricted stock, restricted stock units and other stock-based awards. Subsequent to the adoption of the 2019 Plan, no additional equity awards can be made under the 2017 Plan. As of September 30, 2022 and December 31, 2021, 2,614,198 and 2,875,330 shares of common stock, respectively, were subject to outstanding options under the 2017 Plan. As of September 30, 2022, no shares of restricted stock awards granted under the 2017 Plan were unvested.

Stock Options

The fair value of each employee and non-employee stock option grant is estimated on the date of grant using the Black-Scholes option-pricing model. The Company uses its own volatility to the extent it has sufficient trading history, and for awards in which sufficient trading history is not available, a peer group is used. Due to the lack of historical exercise history, the expected term of the Company’s stock options for employees has been determined utilizing the “simplified” method for awards. The expected term of stock options granted to non-employees is equal to the contractual term of the option award. The risk-free interest rate is determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award for time periods approximately equal to the expected term of the award. Expected dividend yield is zero based on the fact that the Company has never paid cash dividends and does not expect to pay any cash dividends in the foreseeable future.

The following table summarizes stock option activity during the nine months ended September 30, 2022:

	Shares Subject to Options Outstanding			Weighted- Average
	Shares	Weighted- Average Exercise Price		Remaining Contractual Life (Years)	Aggregate Intrinsic Value
					(in thousands)
Outstanding as of December 31, 2021	9,434,660	$	12.24	7.4	$	15,822
Options granted	4,447,720	$	11.50
Options exercised	(269,103)	$	6.40
Options forfeited/cancelled	(823,901)	$	15.77
Outstanding as of September 30, 2022	12,789,376	$	11.89	7.6	$	19,765
Options vested and expected to vest as of September 30, 2022	12,789,376	$	11.89	7.6	$	19,765
Options exercisable as of September 30, 2022	6,115,757	$	12.17	6.4	$	14,169

The aggregate intrinsic value in the above table is calculated as the difference between fair value of the Company’s common stock price on September 30, 2022 and the exercise price of the stock options. The aggregate intrinsic value of stock options exercised during nine months ended September 30, 2022 and 2021 was $1.5 million and $0.7 million, respectively.

The weighted-average grant date fair value per share for the stock option grants during the nine months ended September 30, 2022 and 2021 was $8.27 and $6.85, respectively.

The aggregate fair value of stock options that vested during the nine months ended September 30, 2022 and 2021 was $26.1 million and $17.3 million, respectively.

Restricted Stock

The summary of the Company’s restricted stock activity during the nine months ended September 30, 2022 is as follows:

	Number of Restricted Stock Units Outstanding	Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2021	2,561,219	$	8.67
Granted	572,901	11.94
Vested	(1,087,210)	7.72
Forfeited	(190,222)	10.67
Nonvested at September 30, 2022	1,856,688	$	10.04

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At September 30, 2022, the total unrecognized compensation related to unvested restricted stock awards granted was $10.1 million, which the Company expects to recognize over a weighted-average period of approximately 0.9 years.

Stock-Based Compensation Expense

Stock-based compensation expense has been reported in the Company’s condensed consolidated statements of operations and comprehensive loss as follows (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Research and development	$	5,595	$	4,349	$	17,800	$	14,435
General and administrative	4,527		3,238		13,304		9,914
Total stock-based compensation expense	$	10,122	$	7,587	$	31,104	$	24,349

As of September 30, 2022, the total unrecognized compensation related to unvested stock option awards granted was $46.1 million, which the Company expects to recognize over a weighted-average period of approximately 2.1 years.

As of September 30, 2022, the total unrecognized compensation expense related to the ESPP was $1.6 million, which the Company expects to recognize over a weighted-average period of approximately 0.9 years.

Note 9 - Commitments and Contingencies

Leases

The Company subleases certain office and laboratory space under a non-cancelable operating lease expiring in January 2025 for the initial leased space and for the expansion space leased pursuant to an amendment to the lease agreement entered into in August 2018. In February 2022, the Company exercised its renewal option to extend the term of the expansion space until January 2025. The sublease agreement included options to extend for the entire premises through October 2028. The options to extend must be exercised prior to the termination of the original lease agreement. The period covered by the options was not included in the non-cancellable lease term as it was not determined to be reasonably certain to be executed. The lease is subject to charges for common area maintenance and other costs, and base rent is subject to an annual 3% increase each subsequent year. Costs determined to be variable and not based on an index or rate were not included in the measurement of the operating lease liabilities.

Monthly rent expense is recognized on a straight-line basis over the term of the leases. The operating leases are included in the condensed consolidated balance sheets at the present value of the lease payments at a weighted average discount rate of 7% using the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment as the leases do not provide an implicit rate. The weighted average remaining lease term was 2.3 years.

Lease costs were comprised of the following (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Operating lease cost	$	778	$	1,008	$	2,318	$	3,084
Short-term lease cost	12		13		32		34
Total lease cost	$	790	$	1,021	$	2,350	$	3,118

Cash paid for amounts included in the measurement of operating lease liabilities for the three months ended September 30, 2022 and 2021 was $0.5 million and $1.0 million, respectively, and cash paid for amounts included in the measurement of operating lease liabilities for the nine months ended September 30, 2022 and 2021 was $2.4 million and $3.2 million, respectively.

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Gross future minimum annual rental commitments as of September 30, 2022, were as follows (in thousands):

	Undiscounted Rent Payments
Year ending December 31
2022 (remaining 3 months)	$	806
2023	3,319
2024	3,419
2025	144
Total undiscounted rent payments	$	7,688
Present value discount	(569)
Present value of lease payments	$	7,119
Current portion of operating lease liabilities (included as a component of accrued expenses and other current liabilities)	2,907
Noncurrent operating lease liabilities	4,212
Total operating lease liability	$	7,119

For the three months ended September 30, 2022 and 2021 the Company recorded approximately $0.8 million and $1.1 million, respectively, in rent expense. For the nine months ended September 30, 2022 and 2021, the Company recorded approximately $2.5 million and $3.3 million, respectively, in rent expense.

Litigation

Kuhne vs. Gossamer Bio, Inc., et. al.

On April 3, 2020, Scott Kuhne, individually and on behalf of all others similarly situated, filed a putative class action lawsuit against the Company, certain of its executive officers and directors, and the underwriters of its IPO in the United States District Court for the Southern District of California (Case No. 3:20-cv-00649-DMS-DEB). The second amended complaint was filed on November 20, 2020. The complaint was filed on behalf of all investors who purchased the Company's securities pursuant to or traceable to the Company's February 8, 2019 IPO. The complaint alleged that the Company, certain of its executive officers and directors, and the underwriters of its IPO made false and/or misleading statements and failed to disclose material adverse facts about its business, operations and prospects in violation of Sections 11 and 15 of the Securities Act of 1933, as amended. The plaintiff sought damages, interest, costs, attorneys’ fees, and other unspecified equitable relief. The Company moved to dismiss the complaint on January 19, 2021. On April 19, 2021, the Court granted the Company's motion to dismiss in substantial part without leave to amend, and denied the motion to dismiss as to a single claim. On October 29, 2021, the parties informed the Court that they had reached a settlement in principle, and the Court vacated all deadlines. The parties entered a settlement agreement on February 1, 2022. Pursuant to the agreement, the Company paid approximately $2.4 million, in exchange for customary releases and settlement terms. The Court entered an order preliminarily approving the settlement on March 14, 2022, and the final settlement approval hearing was held on September 30, 2022. The Court subsequently entered orders approving the lead plaintiff’s requested plan of allocation for the settlement fund and request for attorneys’ fees and reimbursement of litigation expenses. The Court entered a judgment approving the class action settlement on September 30, 2022. In accordance with the authoritative guidance on the evaluation of loss contingencies, the Company recorded a $2.4 million litigation charge related to this matter for the year ended December 31, 2021, which was included as a component of accrued expenses and other current liabilities on the Consolidated Balance Sheet for the year ended December 31, 2021.

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ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion and analysis and the unaudited interim condensed consolidated financial statements included in this quarterly report on Form 10-Q should be read in conjunction with the consolidated financial statements and notes thereto for the year ended December 31, 2021 and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations, both of which are contained in our Annual Report on Form 10-K filed with the Securities and Exchange Commission, or SEC, on March 3, 2022.

Forward-Looking Statements

This quarterly report on Form 10-Q contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act, and Section 27A of the Securities Act of 1933, as amended, or the Securities Act. All statements other than statements of historical facts contained in this quarterly report, including statements regarding our future results of operations and financial position, business strategies and plans, research and development plans, the anticipated timing, costs, design and conduct of our ongoing and planned preclinical studies and planned clinical trials for our product candidates, the timing and likelihood of regulatory filings and approvals for our product candidates, the impact of COVID-19 on our business, timing and likelihood of success, plans and objectives of management for future operations and future results of anticipated products, are forward-looking statements. These statements involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.

In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplates,” “believes,” “estimates,” “predicts,” “potential” or “continue” or the negative of these terms or other similar expressions. The forward-looking statements in this quarterly report are only predictions. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition and results of operations. These forward-looking statements speak only as of the date of this quarterly report and are subject to a number of risks, uncertainties and assumptions, including those described in Part II, Item 1A, “Risk Factors” of this report and Part I, Item 1A, “Risk Factors” in our most recent Annual Report on Form 10-K filed with the SEC on March 3, 2022. The events and circumstances reflected in our forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in an evolving environment. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

Overview

We are a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology. We are developing seralutinib for the treatment of pulmonary arterial hypertension, or PAH. In the second quarter of 2022, we completed patient enrollment in our ongoing Phase 2 TORREY Study of seralutinib in PAH. We expect topline results from this clinical trial in the fourth quarter of 2022. Pending the outcomes of the topline results from the ongoing Phase 2 TORREY Study, we expect to initiate a registrational Phase 3 program in PAH in the third quarter of 2023. We are developing GB5121 for the treatment of relapsed / refractory primary CNS lymphoma, or PCNSL, and we commenced enrolling healthy volunteers in a Phase 1 clinical trial in November 2021. We commenced the Phase 1b/2 STAR CNS Study in relapsed / refractory PCNSL and other rare CNS malignancies in the second quarter of 2022. We expect to release results from these open-label GB5121 clinical trials at relevant medical conferences as data become available. We are developing GB7208 for the treatment of multiple sclerosis. GB7208 is currently undergoing preclinical testing. Pending the outcomes of our ongoing GB7208 preclinical work and the seralutinib TORREY Phase 2 topline results, in the second half of 2023, we expect to file an Investigational New Drug, or IND, application with the U.S. Food and Drug Administration, or FDA, related to GB7208. We also have multiple preclinical programs at various stages of development in the therapeutic areas of immunology, inflammation and oncology. We have assembled a deeply experienced and highly skilled group of industry veterans, scientists, clinicians and key opinion leaders from leading biotechnology and pharmaceutical companies, as well as leading academic centers from around the world. Our employees are a team of highly dedicated, passionate individuals who pride themselves on a culture of respect, humility, transparency, inclusion, dedication, collaboration and fun. Our ultimate goal is to enhance and extend the lives of patients.

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We were incorporated in October 2015 and commenced operations in 2017. To date, we have focused primarily on organizing and staffing our company, business planning, raising capital, identifying, acquiring and in-licensing our product candidates and conducting preclinical studies and early clinical trials. We have funded our operations primarily through equity and debt financings. We raised $1,062.1 million from October 2017 through September 30, 2022 through the sale of Series A and B convertible preferred stock financings, issuance of convertible notes, proceeds from our IPO completed in February 2019, proceeds from our Credit Facility, proceeds from our concurrent underwritten public offerings of 5.00% convertible senior notes due 2027, or the 2027 Notes, and our common stock in May 2020, and proceeds from a private placement of our common stock in July 2022. As of September 30, 2022, we had $304.4 million in cash, cash equivalents and marketable securities.

We have incurred significant operating losses since our inception and expect to continue to incur significant operating losses for the foreseeable future. For the three months ended September 30, 2022 and 2021, our net loss was $59.4 million and $60.2 million, respectively. For the nine months ended September 30, 2022 and 2021, our net loss was $173.6 million and $177.7 million, respectively. As of September 30, 2022, we had an accumulated deficit of $976.5 million. We expect our expenses and operating losses will increase substantially as we conduct our ongoing and planned clinical trials, continue our research and development activities and conduct preclinical studies, and seek regulatory approvals for our product candidates, as well as hire additional personnel, protect our intellectual property and incur additional costs associated with being a public company. In addition, as our product candidates progress through development and toward commercialization, we will need to make milestone payments to the licensors and other third parties from whom we have in-licensed or acquired our product candidates, including seralutinib. Our net losses may fluctuate significantly from quarter-to-quarter and year-to-year, depending in particular on the timing of our clinical trials and preclinical studies and our expenditures on other research and development activities.

We do not expect to generate any revenue from product sales unless and until we successfully complete development and obtain regulatory approval for one or more of our product candidates, which we expect will take a number of years. If we obtain regulatory approval for any of our product candidates, we expect to incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution. Accordingly, until such time as we can generate substantial product revenues to support our cost structure, if ever, we expect to finance our cash needs through equity offerings, debt financings or other capital sources, including potentially collaborations, licenses and other similar arrangements. However, we may be unable to raise additional funds or enter into such other arrangements when needed on favorable terms or at all. Our failure to raise capital or enter into such other arrangements when needed could have a negative impact on our financial condition and on our ability to pursue our business plans and strategies. If we are unable to raise additional capital when needed, we could be forced to delay, limit, reduce or terminate our product candidate development or future commercialization efforts or grant rights to develop and market our product candidates even if we would otherwise prefer to develop and market such product candidates ourselves.

COVID-19 Pandemic

As we continue to actively advance our programs, we are in close contact with our principal investigators and clinical sites and continue to assess any impacts of the ongoing COVID-19 global pandemic on our drug manufacturing, nonclinical activities, clinical trials, expected timelines and costs on an ongoing basis. In addition, while we are continuing the clinical trials we have underway in sites across the globe, COVID-19 precautions and related staffing shortages at sites and key vendors have delayed, such as the temporary closure of enrollment in 2020 at certain sites in our ongoing Phase 2 trial for seralutinib in PAH, and may continue to delay completion of our current and future trials and may directly or indirectly impact the timeline for data readouts, initiation of, as well as monitoring, data collection and analysis and other related activities for some of our current and future clinical trials. In light of recent developments relating to the COVID-19 pandemic, and consistent with the FDA’s updated industry guidance for conducting clinical trials, clinical trials may be deprioritized in favor of treating patients who have contracted the virus or to prevent the spread of the virus. The direct and indirect impacts of COVID-19 on our business could alter our forecasted timelines, which could have a material adverse effect on our business, results of operations and financial condition. We will continue to evaluate the impact of the COVID-19 pandemic on our business.

Components of Results of Operations

Revenue

We have not generated any revenue since our inception and do not expect to generate any revenue from the sale of products for the foreseeable future.

Operating expenses

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Research and development

Research and development expenses relate primarily to preclinical and clinical development of our product candidates and discovery efforts, as well as our discontinued clinical product candidates. Research and development expenses are recognized as incurred and payments made prior to the receipt of goods or services to be used in research and development are capitalized until the goods or services are received.

Research and development expenses include or could include:

•salaries, payroll taxes, employee benefits, and stock-based compensation charges for those individuals involved in research and development efforts;

•external research and development expenses incurred under agreements with contract research organizations, or CROs, investigative sites and consultants to conduct our clinical trials and preclinical and non-clinical studies;

•laboratory supplies;

•costs related to manufacturing our product candidates for clinical trials and preclinical studies, including fees paid to third-party manufacturers;

•costs related to compliance with regulatory requirements; and

•facilities, depreciation and other allocated expenses, which include direct and allocated expenses for rent, maintenance of facilities, insurance, equipment and other supplies.

Our direct research and development expenses consist principally of external costs, such as fees paid to CROs, investigative sites and consultants in connection with our clinical trials, preclinical and non-clinical studies, and costs related to manufacturing clinical trial materials. We deploy our personnel and facility related resources across all of our research and development activities. We track external costs and personnel expense on a program-by-program basis and allocate common expenses, such as facility related resources, to each program based on the personnel resources allocated to such program. Stock-based compensation and personnel and common expenses not attributable to a specific program are considered unallocated research and development expenses.

We plan to substantially increase our research and development expenses for the foreseeable future as we continue the development of our product candidates and conduct discovery and research activities for our preclinical programs. We cannot determine with certainty the timing of initiation, the duration or the completion costs of current or future preclinical studies and clinical trials of our product candidates due to the inherently unpredictable nature of preclinical and clinical development. Clinical and preclinical development timelines, the probability of success and development costs can differ materially from expectations. We anticipate that we will make determinations as to which product candidates to pursue and how much funding to direct to each product candidate on an ongoing basis in response to the results of ongoing and future preclinical studies and clinical trials, regulatory developments and our ongoing assessments as to each product candidate’s commercial potential. We will need to raise substantial additional capital in the future.

Our clinical development costs may vary significantly based on factors such as:

•the costs incurred as a result of the COVID-19 pandemic, including clinical trial delays;

•per patient trial costs;

•the number of trials required for approval;

•the number of sites included in the trials;

•the countries in which the trials are conducted;

•the length of time required to enroll eligible patients;

•the number of patients that participate in the trials;

•the number of doses that patients receive;

•the drop-out or discontinuation rates of patients;

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•potential additional safety monitoring requested by regulatory agencies;

•the duration of patient participation in the trials and follow-up;

•the cost and timing of manufacturing our product candidates;

•the phase of development of our product candidates; and

•the efficacy and safety profile of our product candidates.

In process research and development

In process research and development, or IPR&D, expenses include IPR&D acquired as part of an asset acquisition or in-license for which there is no alternative future use, are expensed as incurred.

General and administrative

General and administrative expenses consist primarily of salaries and employee-related costs, including stock-based compensation, for personnel in executive, finance and other administrative functions. Other significant costs include facility-related costs, legal fees relating to intellectual property and corporate matters, professional fees for accounting and consulting services and insurance costs.

We expect our general and administrative expenses will increase for the foreseeable future to support our expanded infrastructure and increased costs of operating as a public company. These increases will likely include increased expenses related to audit, legal, regulatory and tax-related services associated with maintaining compliance with exchange listing and SEC requirements, director and officer insurance premiums, and investor relations costs associated with operating as a public company.

Other income (expense), net

Other income (expense), net consists of (1) interest income on our cash, cash equivalents and marketable securities, (2) sublease income, (3) interest expense related to our Credit Facility and our 2027 Notes, and (4) other miscellaneous income (expense).

Critical Accounting Policies and Estimates

Our management’s discussion and analysis of our financial condition and results of operations are based on our condensed consolidated financial statements, which have been prepared in accordance with generally accepted accounting principles in the United States, or GAAP. The preparation of these financial statements requires us to make judgments and estimates that affect the reported amounts of assets, liabilities, and expenses and the disclosure of contingent assets and liabilities in our condensed consolidated financial statements. We base our estimates on historical experience, known trends and events, and various other factors that are believed to be reasonable under the circumstances. Actual results may differ from these estimates under different assumptions or conditions. On an ongoing basis, we evaluate our judgments and estimates in light of changes in circumstances, facts and experience. During the nine months ended September 30, 2022, there have been no significant changes in our critical accounting policies and estimates as discussed in Item 7, “Management’s Discussion and Analysis of Financial Condition and Results of Operations – Critical Accounting Policies and Estimates” in our Annual Report on Form 10-K filed with the SEC on March 3, 2022.

Results of Operations – Comparison of the Three and Nine Months Ended September 30, 2022 and 2021

The following table sets forth our selected statements of operations data for the three months ended September 30, 2022 and 2021:

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	Three months ended September 30,				2022 vs 2021
	2022		2021		Change
	(in thousands)
Operating expenses:
Research and development	$	44,509	$	43,190	$	1,319
In process research and development	15		15		—
General and administrative	11,497		12,459		(962)
Total operating expenses	56,021		55,664		357
Loss from operations	(56,021)		(55,664)		(357)
Other income (expense)
Interest income	465		191		274
Interest expense	(3,475)		(4,889)		1,414
Other income (expense), net	(332)		115		(447)
Total other expense, net	(3,342)		(4,583)		1,241
Net loss	$	(59,363)	$	(60,247)	$	884

The following table sets forth our selected statements of operations data for the nine months ended September 30, 2022 and 2021:

	Nine months ended September 30,				2022 vs 2021
	2022		2021		Change
	(in thousands)
Operating expenses:
Research and development	$	129,411	$	129,335	$	76
In process research and development	50		60		(10)
General and administrative	34,775		35,068		(293)
Total operating expenses	164,236		164,463		(227)
Loss from operations	(164,236)		(164,463)		227
Other income (expense)
Interest income	989		525		464
Interest expense	(10,423)		(14,503)		4,080
Other income, net	56		721		(665)
Total other income (expense), net	(9,378)		(13,257)		3,879
Net loss	$	(173,614)	$	(177,720)	$	4,106

Operating Expenses

Research and development

Research and development expenses were $44.5 million for the three months ended September 30, 2022, compared to $43.2 million for the three months ended September 30, 2021, for an increase of $1.3 million, which was primarily attributable to an increase of $5.5 million of costs associated with preclinical studies and clinical trials for seralutinib, and an increase of $6.6 million of costs associated with preclinical studies and clinical trials for GB5121, offset by a decrease of $7.8 million of costs associated with preclinical studies and clinical trials for GB004, a decrease of $1.8 million of costs associated with preclinical studies for other discontinued programs, and a decrease of $1.2 million of costs associated with preclinical studies and clinical trials for other programs.

Research and development expenses were $129.4 million for the nine months ended September 30, 2022, compared to $129.3 million for the nine months ended September 30, 2021, for an increase of $0.1 million, which was primarily attributable to an increase of $8.6 million of costs associated with preclinical studies and clinical trials for seralutinib, and an increase of $19.4 million of costs associated with preclinical studies and clinical trials for GB5121, offset by a decrease of $10.2 million of

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costs associated with preclinical studies and clinical trials for GB004, a decrease of $7.0 million of costs associated with preclinical studies for other discontinued programs, and a decrease of $10.7 million of costs associated with preclinical studies and clinical trials for other programs.

The following table shows our research and development expenses by program for the three and nine months ended September 30, 2022 and 2021:

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
	(in thousands)
Seralutinib	$	17,855	$	12,382	$	43,326	$	34,695
GB5121	14,477		7,859		38,013		18,650
GB004	3,858		11,613		20,635		30,857
Other programs	7,873		9,044		25,091		35,771
Other terminated programs	446		2,292		2,346		9,362
Total research and development	$	44,509	$	43,190	$	129,411	$	129,335

In process research and development

There were no significant IPR&D expenses for the three and nine months ended September 30, 2022 and 2021.

General and administrative

General and administrative expenses were $11.5 million for the three months ended September 30, 2022, compared to $12.5 million for the three months ended September 30, 2021, for a decrease of $1.0 million, which was primarily attributable to a $2.6 million decrease in general legal costs as a result of the securities class action settlement accrual in 2021, offset by an increase of $1.3 million in costs related to personnel, and an increase of $0.4 million in costs related to professional services.

General and administrative expenses were $34.8 million for the nine months ended September 30, 2022, compared to $35.1 million for the nine months ended September 30, 2021, for a decrease of $0.3 million, which was primarily attributable to a $3.4 million decrease in general legal costs as a result of the securities class action settlement accrual in 2021, and a decrease of $0.6 million in insurance costs, offset by an increase of $3.4 million in costs related to personnel, and an increase of $0.5 million in other operating costs.

Other expense, net

Other expense, net was $3.3 million for the three months ended September 30, 2022, compared to other expense, net of $4.6 million for the three months ended September 30, 2021, for a decrease of $1.2 million, which was primarily attributable to a decrease in interest expense due to the adoption of ASU 2020-06.

Other expense, net was $9.4 million for the nine months ended September 30, 2022, compared to other expense, net of $13.3 million for the nine months ended September 30, 2021, for a decrease of $3.9 million, which was primarily attributable to a decrease in interest expense due to the adoption of ASU 2020-06.

Liquidity and Capital Resources

We have incurred substantial operating losses since our inception and expect to continue to incur significant operating losses for the foreseeable future and may never become profitable. As of September 30, 2022, we had an accumulated deficit of $976.5 million.

Our primary use of cash is to fund operating expenses, which consist primarily of research and development expenditures, and to a lesser extent, general and administrative expenditures. Cash used to fund operating expenses is impacted by the timing of when we pay these expenses, as reflected in the change in our outstanding accounts payable and accrued expenses.

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Under our license agreement with Pulmokine, as well as our other license and acquisition agreements, we have payment obligations that are contingent upon future events such as our achievement of specified development, regulatory and commercial milestones and are required to make royalty payments in connection with the sale of products developed under those agreements. As of September 30, 2022, we were unable to estimate the timing or likelihood of achieving the milestones or making future product sales. Other contractual obligations include future payments under our Credit Facility, 2027 Notes and existing operating leases.

From our inception through September 30, 2022, our operations have been financed primarily by gross proceeds of $1,062.1 million from the sale of our convertible preferred stock, issuance of convertible notes, proceeds from our IPO, proceeds from our Credit Facility, proceeds from our concurrent underwritten public offerings of 2027 Notes and common stock, and proceeds from our private placement of common stock. As of September 30, 2022 we had cash, cash equivalents and marketable securities of $304.4 million. Cash in excess of immediate requirements is invested in accordance with our investment policy, primarily with a view to capital preservation and liquidity.

On February 12, 2019, we closed our IPO and the underwriters in the IPO purchased 19,837,500 shares of our common stock, including the full exercise of their option to purchase additional shares of common stock. The net proceeds from the IPO were $291.3 million, after deducting underwriting discounts and commissions and estimated offering costs. In connection with the closing of the IPO, the outstanding shares of our convertible preferred stock were converted into shares of common stock at a ratio of 4.5-to-one.

On May 2, 2019, we entered into a credit, guaranty and security agreement, as amended on September 18, 2019 and July 2, 2020, pursuant to which the lenders party thereto agreed to make term loans available to us for working capital and general business purposes, in a principal amount of up to $150.0 million in term loan commitments, including a $30.0 million term loan which was funded at the closing date, with the ability to access the remaining $120.0 million in two additional tranches (each $60.0 million), subject to specified availability periods, the achievement of certain clinical development milestones, minimum cash requirements and other customary conditions, or the Credit Facility. As of September 30, 2022, no tranches under the Credit Facility were available to be drawn.

On April 10, 2020, we filed a registration statement on Form S-3, or the 2020 Shelf Registration Statement, covering the offering from time to time of common stock, preferred stock, debt securities, warrants and units, which registration statement became automatically effective on April 10, 2020.

On May 21, 2020, we issued $200.0 million aggregate principal amount 5.00% convertible senior notes due 2027 in a registered public offering. The interest rate on the 2027 Notes is fixed at 5.00% per annum. Interest is payable semi-annually in arrears on June 1 and December 1 of each year commencing on December 1, 2020. The total net proceeds from the 2027 Notes, after deducting the underwriting discounts and commissions and other offering costs, were approximately $193.6 million. Concurrent with the registered underwritten public offering of the 2027 Notes, we completed an underwritten public offering of 9,433,963 shares of our common stock. We received net proceeds of $117.1 million, after deducting underwriting discounts and commissions and other offering costs. Our concurrent offerings of 2027 Notes and common stock were registered pursuant to the 2020 Shelf Registration Statement.

On March 3, 2022, we filed a registration statement on Form S-3 covering the offering from time to time of common stock, preferred stock, debt securities, warrants and units, which registration statement became automatically effective on March 3, 2022.

On July 15, 2022, we completed a private placement of 16,649,365 shares of our common stock. The aggregate gross proceeds for the private placement were approximately $120.1 million, before deducting offering expenses. On August 9, 2022, we filed a registration statement on Form S-3 registering the shares of common stock issued in the private placement, which registration statement became automatically effective on August 9, 2022.

Additional information about our long-term borrowings is presented in Note 5 “Indebtedness” to the Notes to Unaudited Condensed Consolidated Financial Statements included in Part I, Item 1, of this Form 10-Q, which is incorporated herein by this reference.

The following table shows a summary of our cash flows for each of the nine months ended September 30, 2022 and 2021, respectively:

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	Nine months ended September 30,
	2022		2021
	(in thousands)
Net cash used in operating activities	$	(139,302)	$	(148,381)
Net cash used in investing activities	(9,499)		(127,870)
Net cash provided by financing activities	119,963		2,958
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(1,152)		211
Net decrease in cash, cash equivalents and restricted cash	$	(29,990)	$	(273,082)

Operating activities

During the nine months ended September 30, 2022, operating activities used approximately $139.3 million of cash, primarily resulting from a net loss of $173.6 million and changes in accounts payable of $2.1 million, reduced by stock-based compensation expense of $31.1 million, and accrued research and development expenses of $4.5 million.

During the nine months ended September 30, 2021, operating activities used approximately $148.4 million of cash, primarily resulting from a net loss of $177.7 million reduced by stock-based compensation expense of $24.3 million.

Investing activities

During the nine months ended September 30, 2022, investing activities used approximately $9.5 million of cash, primarily resulting from the purchases of marketable securities of $160.6 million, offset by the maturities of marketable securities of $151.5 million.

During the nine months ended September 30, 2021, investing activities used approximately $127.9 million of cash, primarily resulting from the purchases of marketable securities of $143.9 million, offset by the maturities of marketable securities of $17.6 million.

Financing activities

During the nine months ended September 30, 2022, financing activities provided $120.0 million of cash, primarily resulting from proceeds from the issuance of common stock in a private offering of $119.9 million, proceeds from the exercise of stock options of $1.7 million, and the purchase of shares pursuant to the ESPP of $1.2 million, reduced by the principal repayments of long-term debt of $2.9 million.

During the nine months ended September 30, 2021, financing activities provided $3.0 million of cash, primarily resulting from the purchase of shares pursuant to the ESPP and the exercise of stock options.

Funding requirements

Based on our current operating plan, we believe that our existing cash, cash equivalents and marketable securities, and access to our Credit Facility, will be sufficient to fund our operations into the second quarter of 2024. However, our forecast of the period of time through which our financial resources will be adequate to support our operations is a forward-looking statement that involves risks and uncertainties, and actual results could vary materially. We have based this estimate on assumptions that may prove to be wrong, and we could use our capital resources sooner than we expect. Additionally, the process of testing product candidates in clinical trials is costly, and the timing of progress and expenses in these trials is uncertain.

Our future capital requirements will depend on many factors, including:

•the type, number, scope, progress, expansions, results, costs and timing of, our preclinical studies and clinical trials of our product candidates which we are pursuing or may choose to pursue in the future;

•the costs and timing of manufacturing for our product candidates;

•the costs, timing and outcome of regulatory review of our product candidates;

•the costs of obtaining, maintaining and enforcing our patents and other intellectual property rights;

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•our efforts to enhance operational systems and hire additional personnel to satisfy our obligations as a public company, including enhanced internal controls over financial reporting;

•the costs associated with hiring additional personnel and consultants as our preclinical and clinical activities increase;

•the timing and amount of the milestone or other payments we must make to the licensors and other third parties from whom we have in-licensed our acquired our product candidates;

•the costs and timing of establishing or securing sales and marketing capabilities if any product candidate is approved;

•our ability to achieve sufficient market acceptance, coverage and adequate reimbursement from third-party payors and adequate market share and revenue for any approved products;

•the terms and timing of establishing and maintaining collaborations, licenses and other similar arrangements;

•costs associated with any products or technologies that we may in-license or acquire; and

•any delays and cost increases that result from the COVID-19 pandemic.

Until such time as we can generate substantial product revenues to support our cost structure, if ever, we expect to finance our cash needs through equity offerings, our Credit Facility, debt financings or other capital sources, including potentially collaborations, licenses and other similar arrangements.

However, we may be unable to raise additional funds or enter into such other arrangements when needed on favorable terms or at all. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest of our stockholders will be or could be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of our common stockholders. Debt financing and preferred equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we raise funds through collaborations, licenses and other similar arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us and/or may reduce the value of our common stock. Our failure to raise capital or enter into such other arrangements when needed could have a negative impact on our financial condition and on our ability to pursue our business plans and strategies. If we are unable to raise additional capital when needed, we could be forced to delay, limit, reduce or terminate our product candidate development or future commercialization efforts or grant rights to develop and market our product candidates even if we would otherwise prefer to develop and market such product candidates ourselves.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

As of September 30, 2022, there have been no material changes surrounding our market risk, including interest rate risk, foreign currency exchange risk, and inflation risk, from the discussion provided in Item 7A, “Quantitative and Qualitative Disclosures About Market Risk” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed with the SEC on March 3, 2022.

ITEM 4. CONTROLS AND PROCEDURES

Conclusion Regarding the Effectiveness of Disclosure Controls and Procedures

We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our periodic and current reports that we file with the SEC is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable and not absolute assurance of achieving the desired control objectives. In reaching a reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures. In addition, the design of any system of controls also is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions; over time, control may become inadequate because of changes in conditions, or the degree of compliance with policies or procedures may

30

deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.

Our management, with the participation of our principal executive officer and principal financial officer, has evaluated the effectiveness of our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act as of the end of the period covered by this quarterly report. Based on such evaluation, our principal executive officer and principal financial officer have concluded that as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.

Changes in Internal Control Over Financial Reporting

There have been no changes in our internal control over financial reporting during the three months ended September 30, 2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

31

PART II. OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

We discuss certain legal proceedings in Part I of this Quarterly Report on Form 10-Q under the caption “Item 1. Condensed Consolidated Financial Statements (unaudited),” in Note 9 to our Unaudited Condensed Consolidated Financial Statements, which is captioned “Commitments and Contingencies,” under the sub-caption “Litigation,” and refer you to that discussion, which is incorporated herein by reference to that Note 9, for important information concerning those legal proceedings, including the basis for such actions and, where known, the relief sought.

ITEM 1A. RISK FACTORS

There have been no material changes to the risk factors previously disclosed by us in Part I, Item 1A “Risk Factors” of our Annual Report on Form 10-K for the fiscal year ended December 31, 2021 filed with the SEC on March 3, 2022.

ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

None.

Issuer Repurchases of Equity Securities

None.

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

Not Applicable.

ITEM 4. MINE SAFETY DISCLOSURES

Not Applicable.

ITEM 5. OTHER INFORMATION

None.

ITEM 6. EXHIBITS

The exhibits filed or furnished as part of this Quarterly Report on Form 10-Q are set forth on the Exhibit Index, which Exhibit Index is incorporated herein by reference.

32

EXHIBIT INDEX

Exhibit Number	Exhibit Description	Incorporated by Reference			Filed Herewith
		Form	Date	Number
3.1	Amended and Restated Certificate of Incorporation.	8-K	2/12/2019	3.1
3.2	Amended and Restated Bylaws.	10-Q	5/12/2020	3.2
4.1	Form of Common Stock Certificate.	S-1/A	1/23/2019	4.1
4.2	Amended and Restated Investors’ Rights Agreement, dated July 20, 2018, by and among the Registrant and certain of its stockholders.	S-1	12/21/2018	4.2
4.3	Indenture, dated as of May 21, 2020, by and between the Company and Wilmington Trust, National Association.	8-K	5/21/2020	4.1
4.4	First Supplemental Indenture, dated May 21, 2020, by and between the Company and Wilmington Trust, National Association.	8-K	5/21/2020	4.2
4.5	Form of Global Note representing 5.00% Convertible Senior Notes due 2027 (included as part of Exhibit 4.4).	8-K	5/21/2020	4.3
10.1	Stock Purchase Agreement, dated July 12, 2022, by and among the Company and the Purchasers names therein.	8-K	7/13/2022	10.1
31.1	Certification of Chief Executive Officer of Gossamer Bio, Inc., as required by Rule 13a-14(a) or Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.				X
31.2	Certification of Chief Financial Officer of Gossamer Bio, Inc., as required by Rule 13a-14(a) or Rule 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.				X
32.1*	Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.				X
32.2*	Certification of Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.				X
101.INS	XBRL Report Instance Document				X
101.SCH	XBRL Taxonomy Extension Schema Document				X
101.CAL	XBRL Taxonomy Calculation Linkbase Document				X
101.LAB	XBRL Taxonomy Label Linkbase Document				X
101.PRE	XBRL Presentation Linkbase Document				X
101.DEF	XBRL Taxonomy Extension Definition Linkbase Document				X

* This certification is deemed not filed for purpose of section 18 of the Exchange Act or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act.

33

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

		GOSSAMER BIO, INC.
Date:	November 3, 2022	By:	/s/ Faheem Hasnain
			Faheem Hasnain
			President and Chief Executive Officer
			(Principal Executive Officer)
Date:	November 3, 2022	By:	/s/ Bryan Giraudo
			Bryan Giraudo
			Chief Operating Officer and Chief Financial Officer
			(Principal Financial and Accounting Officer)

34

EX-31.1

EXHIBIT 31.1

CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF

THE SARBANES-OXLEY ACT OF 2002

I, Faheem Hasnain, certify that:

1.I have reviewed this quarterly report on Form 10-Q of Gossamer Bio, Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the registrant and have:

a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 3, 2022

/s/ Faheem Hasnain

Faheem Hasnain

President and Chief Executive Officer

(Principal Executive Officer)

EX-31.2

EXHIBIT 31.2

CERTIFICATION OF PERIODIC REPORT UNDER SECTION 302 OF

THE SARBANES-OXLEY ACT OF 2002

I, Bryan Giraudo, certify that:

1.I have reviewed this quarterly report on Form 10-Q of Gossamer Bio, Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4.The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the registrant and have:

a)Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b)Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c)Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d)Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

5.The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

a)All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b)Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 3, 2022

/s/ Bryan Giraudo

Bryan Giraudo

Chief Operating Officer and Chief Financial Officer

(Principal Financial and Accounting Officer)

EX-32.1

EXHIBIT 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

I, Faheem Hasnain, President and Chief Executive Officer of Gossamer Bio, Inc. (the “Company”), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:

•the accompanying Quarterly Report on Form 10-Q of the Company for the quarter ended September 30, 2022 (the “Report”), as filed with the Securities and Exchange Commission, fully complies with the requirements of Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

•the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.

Date: November 3, 2022

/s/ Faheem Hasnain

Faheem Hasnain

President and Chief Executive Officer

(Principal Executive Officer)

EX-32.2

EXHIBIT 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

I, Bryan Giraudo, Chief Operating Officer and Chief Financial Officer of Gossamer Bio, Inc. (the “Company”), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge:

•the accompanying Quarterly Report on Form 10-Q of the Company for the quarter ended September 30, 2022 (the “Report”), as filed with the Securities and Exchange Commission, fully complies with the requirements of Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended; and

•the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein.

Date: November 3, 2022

/s/ Bryan Giraudo

Bryan Giraudo

Chief Operating Officer and Chief Financial Officer

(Principal Financial and Accounting Officer)

XML

Cover - shares	9 Months Ended
	Sep. 30, 2022	Oct. 31, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Sep. 30, 2022
Document Transition Report	false
Entity File Number	001-38796
Entity Registrant Name	GOSSAMER BIO, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	47-5461709
Entity Address, Address Line One	3013 Science Park Road
Entity Address, City or Town	San Diego
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	92121
City Area Code	858
Local Phone Number	684-1300
Title of 12(b) Security	Common Stock, $0.0001 par value per share
Trading Symbol	GOSS
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		94,476,801
Amendment Flag	false
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q3
Entity Central Index Key	0001728117
Current Fiscal Year End Date	--12-31

XML

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 153,477	$ 183,403
Marketable securities	150,906	141,815
Restricted cash	0	64
Prepaid expenses and other current assets	7,649	6,498
Total current assets	312,032	331,780
Property and equipment, net	4,305	5,320
Operating lease right-of-use assets	6,572	5,477
Other assets	629	1,080
Total assets	323,538	343,657
Current liabilities
Accounts payable	363	3,244
Accrued research and development expenses	20,746	16,205
Accrued expenses and other current liabilities	31,536	20,410
Total current liabilities	52,645	39,859
Long-term convertible senior notes	195,496	150,038
Debt, non-current portion	14,834	29,079
Operating lease liabilities - long-term	4,212	3,218
Total liabilities	267,187	222,194
Commitments and contingencies (Note 9)
Stockholders' equity
Common stock, $0.0001 par value; 700,000,000 shares authorized as of September 30, 2022 and December 31, 2021; 94,135,098 shares issued and 93,914,200 shares outstanding as of September 30, 2022, and 76,470,588 shares issued and 75,752,664 shares outstanding as of December 31, 2021	10	8
Additional paid-in capital	1,033,385	932,944
Accumulated deficit	(976,459)	(811,534)
Accumulated other comprehensive (loss) income	(585)	45
Total stockholders' equity	56,351	121,463
Total liabilities and stockholders' equity	$ 323,538	$ 343,657

XML

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Sep. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, authorized (in shares)	700,000,000	700,000,000
Common stock, issued (in shares)	94,135,098	76,470,588
Common stock, outstanding (in shares)	93,914,200	75,752,664

XML

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Operating expenses:
Research and development	$ 44,509	$ 43,190	$ 129,411	$ 129,335
In process research and development	15	15	50	60
General and administrative	11,497	12,459	34,775	35,068
Total operating expenses	56,021	55,664	164,236	164,463
Loss from operations	(56,021)	(55,664)	(164,236)	(164,463)
Other expense
Interest income	465	191	989	525
Interest expense	(3,475)	(4,889)	(10,423)	(14,503)
Other income (expense), net	(332)	115	56	721
Total other expense, net	(3,342)	(4,583)	(9,378)	(13,257)
Net loss	(59,363)	(60,247)	(173,614)	(177,720)
Other comprehensive income (loss):
Foreign currency translation	(173)	(64)	(319)	(274)
Unrealized gain (loss) on marketable securities	102	(73)	(311)	(188)
Other comprehensive income (loss)	(71)	(137)	(630)	(462)
Comprehensive loss	$ (59,434)	$ (60,384)	$ (174,244)	$ (178,182)
Net loss per share, basic (in dollars per share)	$ (0.65)	$ (0.80)	$ (2.14)	$ (2.38)
Net loss per share, diluted (in dollars per share)	$ (0.65)	$ (0.80)	$ (2.14)	$ (2.38)
Weighted average common shares outstanding, basic (in shares)	91,181,427	75,001,510	81,304,089	74,592,632
Weighted average common shares outstanding, diluted (in shares)	91,181,427	75,001,510	81,304,089	74,592,632

XML

Condensed Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common stock	Additional paid-in capital	Additional paid-in capital Cumulative Effect, Period of Adoption, Adjustment	Accumulated deficit	Accumulated deficit Cumulative Effect, Period of Adoption, Adjustment	Accumulated other comprehensive income (loss)
Beginning balance (in shares) at Dec. 31, 2020			73,874,904
Beginning balance at Dec. 31, 2020	$ 320,684		$ 8	$ 897,607		$ (577,530)		$ 599
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock (in shares)			238,962
Exercise of stock option (in shares)			5,721
Exercise of stock options (in dollars)	15			15
Stock-based compensation	8,708			8,708
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)			95,004
Issuance of common stock pursuant to Employee Stock Purchase Plan	759			759
Issuance of common stock for restricted stock units vested (in shares)			278,559
Net loss	(57,641)					(57,641)
Other comprehensive loss	(441)							(441)
Ending balance (in shares) at Mar. 31, 2021			74,493,150
Ending balance at Mar. 31, 2021	272,084		$ 8	907,089		(635,171)		158
Beginning balance (in shares) at Dec. 31, 2020			73,874,904
Beginning balance at Dec. 31, 2020	320,684		$ 8	897,607		(577,530)		599
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(177,720)
Other comprehensive loss	(462)
Ending balance (in shares) at Sep. 30, 2021			75,300,074
Ending balance at Sep. 30, 2021	169,809		$ 8	924,914		(755,250)		137
Beginning balance (in shares) at Dec. 31, 2020			73,874,904
Beginning balance at Dec. 31, 2020	$ 320,684		$ 8	897,607		(577,530)		599
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting Standards Update [Extensible Enumeration]	Accounting Standards Update 2020-06 [Member]
Ending balance (in shares) at Dec. 31, 2021			75,752,664
Ending balance at Dec. 31, 2021	$ 121,463	$ (44,838)	$ 8	932,944	$ (53,527)	(811,534)	$ 8,689	45
Beginning balance (in shares) at Mar. 31, 2021			74,493,150
Beginning balance at Mar. 31, 2021	272,084		$ 8	907,089		(635,171)		158
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock (in shares)			231,710
Exercise of stock option (in shares)			103,922
Exercise of stock options (in dollars)	271			271
Stock-based compensation	8,054			8,054
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)			6,170
Net loss	(59,832)					(59,832)
Other comprehensive loss	116							116
Ending balance (in shares) at Jun. 30, 2021			74,834,952
Ending balance at Jun. 30, 2021	220,693		$ 8	915,414		(695,003)		274
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock (in shares)			228,084
Exercise of stock option (in shares)			171,252
Exercise of stock options (in dollars)	1,357			1,357
Stock-based compensation	7,587			7,587
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)			65,786
Issuance of common stock pursuant to Employee Stock Purchase Plan	556			556
Net loss	(60,247)					(60,247)
Other comprehensive loss	(137)							(137)
Ending balance (in shares) at Sep. 30, 2021			75,300,074
Ending balance at Sep. 30, 2021	169,809		$ 8	924,914		(755,250)		137
Beginning balance (in shares) at Dec. 31, 2021			75,752,664
Beginning balance at Dec. 31, 2021	121,463	(44,838)	$ 8	932,944	(53,527)	(811,534)	8,689	45
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock (in shares)			165,675
Exercise of stock option (in shares)			39,525
Exercise of stock options (in dollars)	126			126
Stock-based compensation	10,983			10,983
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)			77,496
Issuance of common stock pursuant to Employee Stock Purchase Plan	595			595
Issuance of common stock for restricted stock units vested (in shares)			518,577
Net loss	(57,785)					(57,785)
Other comprehensive loss	(385)							(385)
Ending balance (in shares) at Mar. 31, 2022			76,553,937
Ending balance at Mar. 31, 2022	30,159		$ 8	891,121		(860,630)		(340)
Beginning balance (in shares) at Dec. 31, 2021			75,752,664
Beginning balance at Dec. 31, 2021	$ 121,463	$ (44,838)	$ 8	932,944	$ (53,527)	(811,534)	$ 8,689	45
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Exercise of stock option (in shares)	269,103
Net loss	$ (173,614)
Other comprehensive loss	(630)
Ending balance (in shares) at Sep. 30, 2022			93,914,200
Ending balance at Sep. 30, 2022	56,351		$ 10	1,033,385		(976,459)		(585)
Beginning balance (in shares) at Mar. 31, 2022			76,553,937
Beginning balance at Mar. 31, 2022	30,159		$ 8	891,121		(860,630)		(340)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted stock (in shares)			165,675
Exercise of stock option (in shares)			8,005
Exercise of stock options (in dollars)	21			21
Stock-based compensation	9,999			9,999
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)			8,607
Net loss	(56,466)					(56,466)
Other comprehensive loss	(174)							(174)
Ending balance (in shares) at Jun. 30, 2022			76,736,224
Ending balance at Jun. 30, 2022	(16,461)		$ 8	901,141		(917,096)		(514)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock in connection with a private offering, net of offering costs (in shares)			16,649,365
Issuance of common stock in connection with a private offering, net of offering costs of $184	$ 119,928		$ 2	119,926
Vesting of restricted stock (in shares)	0		165,676
Exercise of stock option (in shares)			219,573
Exercise of stock options (in dollars)	$ 1,576			1,576
Stock-based compensation	10,122			10,122
Issuance of common stock pursuant to Employee Stock Purchase Plan (in shares)			80,362
Issuance of common stock pursuant to Employee Stock Purchase Plan	620			620
Issuance of common stock for restricted stock units vested (in shares)			63,000
Net loss	(59,363)					(59,363)
Other comprehensive loss	(71)							(71)
Ending balance (in shares) at Sep. 30, 2022			93,914,200
Ending balance at Sep. 30, 2022	$ 56,351		$ 10	$ 1,033,385		$ (976,459)		$ (585)

XML

Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Parenthetical) $ in Thousands	3 Months Ended
	Sep. 30, 2022 USD ($)
Statement of Stockholders' Equity [Abstract]
Offering costs	$ 184

XML

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities
Net loss	$ (173,614)	$ (177,720)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	1,372	1,292
Stock-based compensation expense	31,104	24,349
In process research and development expenses	50	60
Amortization of operating lease right-of-use assets	1,934	2,593
Amortization of long-term debt discount and issuance costs	893	4,983
Amortization of premium (discount) on marketable securities, net of accretion of discounts	(261)	186
Loss on disposal of property and equipment	0	84
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(1,151)	1,221
Other assets	451	(87)
Operating lease liabilities	(2,030)	(2,706)
Accounts payable	(2,098)	(6,808)
Accrued expenses	(1,561)	4,715
Accrued research and development expenses	4,541	3,375
Accrued compensation and benefits	(1,415)	(3,918)
Accrued interest expense	2,483	0
Net cash used in operating activities	(139,302)	(148,381)
Cash flows from investing activities
Research and development asset acquisitions, net of cash acquired	(50)	(60)
Purchase of marketable securities	(160,641)	(143,897)
Maturities of marketable securities	151,500	17,550
Purchase of property and equipment	(308)	(1,463)
Net cash used in investing activities	(9,499)	(127,870)
Cash flows from financing activities
Proceeds from issuance of common stock in a private offering, net of offering costs	119,928	0
Proceeds from issuance of common stock pursuant to Employee Stock Purchase Plan	1,215	1,315
Proceeds from the exercise of stock options	1,723	1,643
Principal repayments of long-term debt	(2,903)	0
Net cash provided by financing activities	119,963	2,958
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(1,152)	211
Net decrease in cash, cash equivalents and restricted cash	(29,990)	(273,082)
Cash, cash equivalents and restricted cash, at the beginning of the period	183,467	486,620
Cash, cash equivalents and restricted cash, at the end of the period	153,477	213,538
Supplemental disclosure of cash flow information:
Cash paid for interest	7,042	7,055
Supplemental disclosure of noncash investing and financing activities:
Operating lease right-of-use asset obtained in exchange for lease liability	3,029	0
Derecognition ROU lease assets obtained in exchange for operating lease liabilities	0	1,650
Change in unrealized gain (loss) on marketable securities, net	(311)	188
Purchases of property and equipment included in accounts payable and accrued expenses and other current liabilities	$ 49	$ 0

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Description of the Business

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Description of the Business

Description of the Business

Gossamer Bio, Inc. (including its subsidiaries, referred to as “we,” “us,” “our,”, or the “Company”) is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology. The Company was incorporated in the state of Delaware on October 25, 2015 (originally as FSG Bio, Inc.) and is based in San Diego, California.

The unaudited condensed consolidated financial statements include the accounts of Gossamer Bio, Inc. and its wholly owned subsidiaries. All intercompany balances and transactions among the consolidated entity have been eliminated in consolidation.

Liquidity and Capital Resources

The Company has incurred significant operating losses since its inception. As of September 30, 2022, the Company had an accumulated deficit of $976.5 million. From the Company’s inception through September 30, 2022, the Company has funded its operations primarily through equity and debt financings. The Company raised $1,062.1 million from October 2017 through September 30, 2022 through the sale of Series A and B convertible preferred stock, issuance of convertible notes, its initial public offering ("IPO"), the Credit Facility and 2027 Notes (as defined in Note 5 below), and issuances of common stock in May 2020 and July 2022. See Note 5 for additional information regarding the Credit Facility and the 2027 Notes.

The Company expects to continue to incur significant operating losses for the foreseeable future and may never become profitable. As a result, the Company will need to raise additional capital through equity offerings, debt financings or other capital sources, including potential collaborations, licenses and other similar arrangements. Management believes that it has sufficient working capital on hand to fund operations through at least the next 12 months from the date these condensed consolidated financial statements were available to be issued. There can be no assurance that the Company will be successful in acquiring additional funding, that the Company’s projections of its future working capital needs will prove accurate, or that any additional funding would be sufficient to continue operations in future years.

COVID-19

The COVID-19 pandemic has caused significant business disruption around the globe. The extent of the impact of COVID-19 on the Company’s operational and financial performance will depend on certain developments, including the duration and spread of the pandemic worldwide and the impact on the Company’s clinical trials, employees and vendors. To the extent possible, and consistent with applicable guidance from federal, state and local authorities, the Company is conducting business as usual. The Company will continue to actively monitor the evolving situation related to COVID-19 and may take further actions that alter its operations, including those that may be required by federal, state or local authorities, or that the Company determines are in the best interests of its employees and other third parties with whom the Company does business. At this point, the degree to which COVID-19, including new variants of the virus that causes COVID-19, may continue to impact the Company’s financial condition or results of operations remains uncertain. A prolonged pandemic could have a material and adverse impact on the financial results and business operations of the Company, including the timing and ability of the Company to complete certain clinical trials and other efforts required to advance the development of its product candidates and raise additional capital. For example, certain sites temporarily closed enrollment in the Company's Phase 2 clinical trial in pulmonary arterial hypertension ("PAH") in 2020 as a result of the COVID-19 pandemic and related staffing shortages at sites and key vendors. In addition, due to the challenges of enrolling patients worldwide posed by the COVID-19 pandemic and related staffing shortages at sites and key vendors, the Company previously experienced delays in enrollment of patients in its Phase 2 clinical trial of seralutinib, also known as GB002, in PAH.

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Summary of Significant Accounting Policies

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) for interim financial information and with the instructions of the Securities and Exchange Commission (“SEC”) on Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and disclosures required by GAAP for complete financial statements. In the opinion of management, the condensed consolidated financial statements include all adjustments necessary, which are of a normal and recurring nature, for the fair presentation of the Company’s financial position and of the results of operations and cash flows for the periods presented. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto for the year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 3, 2022. The results of operations for the interim period shown in this report are not necessarily indicative of the results that may be expected for any other interim period or for the full year. The balance sheet at December 31, 2021, has been derived from the audited financial statements at that date.

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of expenses during the reporting period. The most significant estimates in the Company’s condensed consolidated financial statements relate to the allocation of the 2027 Notes into liability and equity components and accrued research and development expenses. These estimates and assumptions are based on current facts, historical experience and various other factors believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities and the recording of expenses that are not readily apparent from other sources. Actual results could differ from those estimates.

Recent Accounting Pronouncements - Adopted

In August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2020-06, Debt: Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity's Own Equity (Subtopic 815-40) (“ASU 2020-06”), which simplifies the accounting for convertible instruments and contracts in an entity's own equity. This guidance is effective for annual reporting periods beginning after December 15, 2021, including interim periods within those years, with early adoption permitted only as of annual reporting periods beginning after December 15, 2020.

The Company adopted ASU 2020-06 on January 1, 2022 using the modified retrospective approach, and accordingly the Company recorded an adjustment that reflects the 2027 Notes as if the embedded conversion feature had not been separated. The impact upon adoption on the Consolidated Balance Sheets was an increase of $44.8 million in convertible senior notes, net, a write-off of $9.4 million in deferred income tax liabilities and a decrease of $53.5 million in additional paid-in capital. In addition, upon adoption, there was an adjustment of $8.7 million to increase the beginning balance of accumulated deficit on the Consolidated Balance Sheets for previously recognized interest expense related to amortization of debt discount related to the carrying value of the embedded conversion feature upon issuance. There was no impact to the Company’s net loss per share calculation. See Note 5 "Indebtedness" for further information regarding the 2027 Notes.

Net Loss Per Share

Basic net loss per share of common stock is computed by dividing net loss attributable to common stockholders by the weighted average number of shares of common stock outstanding for the period. The Company uses the if-converted method for assumed conversion of the 2027 Notes to compute the weighted average shares of common stock outstanding for diluted net loss per share. Diluted net loss per share excludes the potential impact of the Company’s common stock options and unvested shares of restricted stock and the potential shares issuable upon conversion of the 2027 Notes because their effect would be anti-dilutive due to the Company’s net loss. Since the Company had a net loss in each of the periods presented, basic and diluted net loss per common share are the same.

The table below provides potentially dilutive securities not included in the calculation of the diluted net loss per share because to do so would be anti-dilutive:

	As of September 30,
	2022	2021
2027 Notes	12,321,900	12,321,900
Shares issuable upon exercise of stock options	12,789,376	9,540,332
Non-vested shares under restricted stock grants	1,856,688	3,020,509
Total potentially dilutive securities	26,967,964	24,882,741

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Balance Sheet Accounts and Supplemental Disclosures

9 Months Ended

Sep. 30, 2022

Balance Sheets Accounts And Supplemental Disclosures [Abstract]

Balance Sheet Accounts and Supplemental Disclosures

Balance Sheet Accounts and Supplemental Disclosures

Property and Equipment

Property and equipment, net consisted of the following (in thousands):

	Estimated Useful Life (in years)	September 30, 2022		December 31, 2021
Office equipment	3-7	$	1,097	$	1,097
Computer equipment	5	123		123
Software	3	130		130
Lab equipment	2-5	6,044		5,688
Leasehold improvements	6-7	2,562		2,562
Total property and equipment		9,956		9,600
Less: accumulated depreciation		5,651		4,280
Property and equipment, net		$	4,305	$	5,320

For each of the three months ended September 30, 2022 and 2021 the Company recorded approximately $0.5 million in depreciation expense, and for the nine months ended September 30, 2022 and 2021, the Company recorded approximately $1.4 million and $1.3 million, respectively, in depreciation expense, in each case, which is included in general and administrative expense and research and development expense on the consolidated statements of operations and comprehensive loss.

Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):

	As of
	September 30, 2022		December 31, 2021
Accrued compensation and benefits	$	10,501	$	11,916
Operating lease liabilities	2,907		2,902
Debt, current	11,613		—
Accrued consulting fees	1,433		956
Accrued interest	3,549		1,066
Accrued legal fees	251		202
Accrued litigation liability	—		2,375
Accrued accounting fees	429		154
Accrued other	853		839
Total accrued expenses and other current liabilities	$	31,536	$	20,410

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Fair Value Measurements and Available for Sale Investments

9 Months Ended

Sep. 30, 2022

Fair Value Measurements And Available For Sale Investments [Abstract]

Fair Value Measurements and Available for Sale Investments

Fair Value Measurements and Available for Sale Investments

Fair Value Measurements

The accounting guidance defines fair value, establishes a consistent framework for measuring fair value and expands disclosure for each major asset and liability category measured at fair value on either a recurring or nonrecurring basis. Fair value is defined as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumptions, the accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:

Level 1: Observable inputs such as quoted prices in active markets;

Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and

Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions.

The Company classifies its cash equivalents and available-for-sale investments within Level 1 or Level 2. The fair value of the Company’s investment grade corporate debt securities and commercial paper is determined using proprietary valuation models and analytical tools, which utilize market pricing or prices for similar instruments that are both objective and publicly available, such as matrix pricing or reported trades, benchmark yields, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, and offers.

Assets and Liabilities Measured at Fair Value on a Recurring Basis

The following table presents the hierarchy for assets measured at fair value on a recurring basis as of September 30, 2022 and December 31, 2021 (in thousands):

	Fair Value Measurements at End of Period Using:
	Total Fair Value		Quoted Market Prices for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
As of September 30, 2022
Money market funds	$	81,850	$	81,850	$	—	$	—
U.S. Treasury and agency securities	58,883		58,883		—		—
Commercial paper	119,603		—		119,603		—
Corporate debt securities	12,347		—		12,347		—
As of December 31, 2021
Money market funds	$	139,794	$	139,794	$	—	$	—
Commercial paper	113,939		—		113,939		—
Corporate debt securities	37,873		—		37,873		—

The Company did not reclassify any investments between levels in the fair value hierarchy during the periods presented.

Fair Value of Other Financial Instruments

As of September 30, 2022 and December 31, 2021, the carrying amounts of the Company’s financial instruments, which include cash, restricted cash, prepaid and other current assets, interest receivable, accrued research and development expenses, accounts payable and accrued expenses and other current liabilities, approximate fair values because of their short maturities.

Interest receivable as of September 30, 2022 and December 31, 2021, was $0.1 million and $0.2 million, respectively, and is recorded as a component of prepaid expenses and other current assets on the condensed consolidated balance sheets.

The Company believes that its Credit Facility bears interest at a rate that approximates prevailing market rates for instruments with similar characteristics and, accordingly, the carrying value of the Credit Facility approximates fair value. The Company estimates the fair value of long-term debt utilizing an income approach. The Company uses a present value calculation to discount principal and interest payments and the final maturity payment on these liabilities using a discounted cash flow model based on observable inputs. The debt instrument is then discounted based on what the current market rates

would be as of the reporting date. Based on the assumptions used to value these liabilities at fair value, the debt instrument is categorized as Level 2 in the fair value hierarchy.

As of September 30, 2022 and December 31, 2021, the fair value of the Company’s 2027 Notes was $227.5 million and $190.5 million, respectively. The fair value was determined on the basis of market prices observable for similar instruments and is considered Level 2 in the fair value hierarchy (see Note 5).

Available for Sale Investments

The Company invests its excess cash in U.S. Treasury and agency securities, corporate debt securities, and commercial paper, which are classified as available-for-sale investments. These investments are carried at fair value and are included in the tables below. The Company evaluates securities with unrealized losses to determine whether such losses, if any, are due to credit-related factors. Realized gains and losses are calculated using the specific identification method and recorded in other income (expense) in the Company's condensed consolidated statement of operations and comprehensive loss. The Company does not intend to sell the investments and it is not more likely than not that the Company will be required to sell the investments before recover of their amortized cost basis.

The aggregate market value, cost basis, and gross unrealized losses of available-for-sale investments by security type, classified in marketable securities and long-term investments as of September 30, 2022 and December 31, 2021 are as follows (in thousands):

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Total Fair Value
As of September 30, 2022
U.S. Treasury and agency securities	$	41,494	$	—	$	(79)	$	41,415
Corporate debt securities	12,426		—		(79)		12,347
Commercial paper	97,345		—		(201)		97,144
Total marketable securities	$	151,265	$	—	$	(359)	$	150,906
As of December 31, 2021
Corporate debt securities	$	37,921	$	—	$	(48)	$	37,873
Commercial paper	103,942		—		—		103,942
Total marketable securities	$	141,863	$	—	$	(48)	$	141,815

As of September 30, 2022 and December 31, 2021, the Company classified $39.9 million and $10.0 million, respectively, of assets with original maturities of 90 days or less as cash and cash equivalents.

At each reporting date, the Company performs an evaluation of impairment to determine if any unrealized losses are due to credit-related factors. The Company records an allowance for credit losses when unrealized losses are due to credit-related factors. Factors considered when evaluating available-for-sale investments for impairment include the severity of the impairment, changes in underlying credit ratings, the financial condition of the issuer, the probability that the scheduled cash payments will continue to be made and the Company’s intent and ability to hold the investment until recovery of the amortized cost basis. The Company intends and has the ability to hold its investments in unrealized loss positions until their amortized cost basis has been recovered. As of September 30, 2022 and December 31, 2021, there were no material declines in the market value of the Company’s available-for-sale investments due to credit-related factors.

Contractual maturities of available-for-sale debt securities, as of September 30, 2022, were as follows (in thousands):

	Estimated  Fair Value
Less than one year	$	150,906
Greater than one year	—
Total	$	150,906

The Company has the ability, if necessary, to liquidate any of its cash equivalents and marketable securities to meet its liquidity needs in the next 12 months.

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Indebtedness

9 Months Ended

Sep. 30, 2022

Debt Disclosure [Abstract]

Indebtedness

Indebtedness

Credit Facility

On May 2, 2019, the Company entered into a credit, guaranty and security agreement, as amended on September 18, 2019 and July 2, 2020 (the “Credit Facility”), with MidCap Financial Trust (“MidCap”), as agent and lender, and the additional lenders party thereto from time to time (together with MidCap, the “Lenders”), pursuant to which the Lenders, including affiliates of MidCap and Silicon Valley Bank, agreed to make term loans available to the Company for working capital and general business purposes, in a principal amount of up to $150.0 million in term loan commitments, including a $30.0 million term loan that was funded at the closing date, with the ability to access the remaining $120.0 million in two additional tranches (each $60.0 million), subject to specified availability periods, the achievement of certain clinical development milestones, minimum cash requirements and other customary conditions. The Company did not achieve the clinical development milestone required to access one of the $60.0 million tranches. The Company, GB001, Inc., GB002, Inc., and GB004, Inc., each wholly-owned subsidiaries of the Company, are designated as co-borrowers to the Credit Facility, whereas GB003, Inc., GB005, Inc., GB006, Inc., GB007, Inc., GB008, Inc. and Gossamer Bio Services, Inc., each wholly-owned subsidiaries of the Company, are designated as guarantors. The remaining tranche is available no earlier than the satisfaction of the applicable funding conditions, including the applicable clinical development milestone, and no later than December 31, 2022. As of September 30, 2022, no tranches under the Credit Facility were available to be drawn. The Credit Facility is secured by substantially all of the Company’s and its domestic subsidiaries’ personal property, including intellectual property.

Each term loan under the Credit Facility bears interest at an annual rate equal to the sum of (i) one-month LIBOR (customarily defined, with a change to prime rate if LIBOR funding becomes unlawful or impractical) plus (ii) 7.00%, subject to a LIBOR floor of 2.00%. The borrower is required to make interest-only payments on the term loan for all payment dates prior to July 1, 2022.  The term loans under the Credit Facility began amortizing on July 1, 2022, with equal monthly payments of principal plus interest being made by the Company to the Lenders in consecutive monthly installments following such interest-only period until the Credit Facility matures on January 1, 2025. Upon final repayment of the term loans, the borrower must pay an exit fee of 1.75% of the amount borrowed under the Credit Facility, less any partial exit fees previously paid. Upon partial prepayment of a portion of the term loans, the borrower must pay a partial exit fee of 1.75% of the principal being prepaid. At the borrower’s option, the borrower may prepay the outstanding principal balance of the term loan in whole or in part, subject to a prepayment fee of 3.00% of any amount prepaid if the prepayment occurs through and including the first anniversary of the second amendment effective date, 2.00% of the amount prepaid if the prepayment occurs after the first anniversary of the second amendment effective date through and including the second anniversary of the second amendment effective date, and 1.00% of any amount prepaid after the second anniversary of the second amendment effective date and prior to January 1, 2025.

The Credit Facility includes affirmative and negative covenants applicable to the Company and certain of its subsidiaries. The affirmative covenants include, among others, covenants requiring such entities to maintain their legal existence and governmental approvals, deliver certain financial reports, maintain insurance coverage, maintain property, pay taxes, satisfy certain requirements regarding accounts and comply with laws and regulations.  The negative covenants include, among others, restrictions on such entities from transferring collateral, incurring additional indebtedness, engaging in mergers or acquisitions, paying dividends or making other distributions, making investments, creating liens, amending material agreements and organizational documents, selling assets and suffering a change in control, in each case subject to certain exceptions. The Company and certain of its subsidiaries are also subject to an ongoing minimum cash financial covenant in which they must maintain unrestricted cash in an amount not less than 25% of the outstanding principal amount of the term loans. As of September 30, 2022, the Company was in compliance with these covenants.

The Credit Facility also includes events of default, the occurrence and continuation of which could cause interest to be charged at the rate that is otherwise applicable plus 3.00% and would provide MidCap, as agent, with the right to exercise remedies against the Company and/or certain of its subsidiaries, and the collateral securing the Credit Facility, including foreclosure against the properties securing the credit facilities, including cash. These events of default include, among other things, failure to pay any amounts due under the Credit Facility, a breach of covenants under the Credit Facility, insolvency or the occurrence of insolvency events, the occurrence of a change in control, the occurrence of certain U.S. Food and Drug Administration (“FDA”) and regulatory events, failure to remain registered with the SEC and listed for trading on Nasdaq, the occurrence of a material adverse change, the occurrence of a default under a material agreement reasonably expected to result in a material adverse change, the occurrence of certain defaults under certain other indebtedness in an amount greater than $2.5 million and the occurrence of certain defaults under subordinated indebtedness and convertible indebtedness.

Debt consisted of the following (in thousands):

	September 30, 2022		December 31, 2021
Debt, current portion	$	11,613	$	—
Debt, non-current portion	15,484		30,000
Total debt	27,097		30,000
Less: unamortized debt discount and issuance costs	(650)		(921)
Debt, net	$	26,447	$	29,079

The scheduled future minimum principal payments are as follows (in thousands):

	September 30, 2022
2022 (remaining 3 months)	$	2,903
2023	11,613
2024	11,613
2025	968
Total	$	27,097

5.00% Convertible Senior Notes due 2027

On May 21, 2020, the Company issued $200.0 million aggregate principal amount of 5.00% convertible senior notes due 2027 in a public offering (the "2027 Notes"). The 2027 Notes were registered pursuant to the Company’s shelf registration statement on Form S-3 filed with the SEC on April 10, 2020. The interest rate on the 2027 Notes is fixed at 5.00% per annum. Interest is payable semi-annually in arrears on June 1 and December 1 of each year, commencing on December 1, 2020. The 2027 Notes will mature on June 1, 2027. The net proceeds from the offering, after deducting the underwriting discounts and commissions and other offering costs, were approximately $193.6 million. The 2027 Notes may be settled in cash, shares of the Company’s common stock, or a combination thereof, solely at the Company’s election. The initial conversion rate of the 2027 Notes is 61.6095 shares per $1,000 principal amount, which is equivalent to a conversion price of approximately $16.23 per share, subject to adjustments. In addition, following certain corporate events that occur prior to the maturity date or if the Company issues a notice of redemption, the Company will increase the conversion rate for a holder who elects to convert its 2027 Notes in connection with such a corporate event during the related redemption period in certain circumstances. 

The 2027 Notes are senior unsecured obligations of the Company, ranking senior in right of payment to any of the Company’s indebtedness that is expressly subordinated in right of payment to the 2027 Notes, and are effectively subordinated to the Company’s existing and future secured indebtedness, to the extent of the value of the collateral securing that indebtedness, including all indebtedness under the Credit Facility.

Holders may convert their notes at their option only in the following circumstances: (1) during any calendar quarter (and only during such calendar quarter) commencing after the calendar quarter ending on September 30, 2020, if the last reported sale price per share of the Company’s common stock exceeds 130% of the conversion price for each of at least 20 trading days (whether or not consecutive) during the 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter; (2) during the five consecutive business days immediately after any 10 consecutive trading day period (such 10 consecutive trading day period, the “measurement period”) in which the trading price per $1,000 principal amount of notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price per share of the Company’s common stock on such trading day and the conversion rate on such trading day; (3) upon the occurrence of certain corporate events or distributions on the Company’s common stock; (4) if the Company calls such notes for redemption; and (5) at any time from, and including, March 1, 2027 until the close of business on the scheduled trading day immediately before the maturity date.

The Company will not have the right to redeem the 2027 Notes prior to June 6, 2024. On or after June 6, 2024 and on or before the 50th scheduled trading day immediately before the maturity date, the Company may redeem the 2027 Notes, in whole or in part, if the last reported sale price of the Company’s common stock has been at least 130% of the conversion price then in effect on (1) each of at least 20 trading days (whether or not consecutive) during the 30 consecutive trading days ending on, and including, the trading day immediately before the date the Company sends the related redemption notice; and (2) the trading day immediately before the date the Company sends such notice. In the case of any optional redemption, the Company

will redeem the 2027 Notes at a redemption price equal to 100% of the principal amount of such Notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date.

If the Company undergoes a fundamental change prior to the maturity date of the 2027 Notes, holders of the 2027 Notes may require the Company to repurchase for cash all or part of their 2027 Notes at a repurchase price equal to 100% of the principal amount of the 2027 Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date.

The indenture governing the 2027 Notes provides for customary terms and covenants, including that upon certain events of default, either the trustee or the holders of not less than 25% in aggregate principal amount of the 2027 Notes then outstanding may declare the unpaid principal amount of the 2027 Notes and accrued and unpaid interest, if any, thereon immediately due and payable. As of September 30, 2022, the Company was in compliance with these covenants. In the case of certain events of bankruptcy, insolvency or reorganization, the principal amount of the 2027 Notes together with accrued and unpaid interest, if any, thereon will automatically become and be immediately due and payable.

As of September 30, 2022, there were no events or market conditions that would allow holders to convert the 2027 Notes. When the 2027 Notes become convertible within 12 months of the balance sheet date, the carrying value of the 2027 Notes will be reclassified to short-term.

In accounting for the issuance of the 2027 Notes prior to the adoption of ASU 2020-06, the Company separated the 2027 Notes into liability and equity components. The carrying amount of the liability component was calculated by measuring the fair value of similar debt instruments that do not have associated convertible features. The carrying amount of the equity component representing the conversion option was $53.5 million and was determined by deducting the fair value of the liability component from the par value of the 2027 Notes. The equity component is not remeasured as long as it continues to meet the conditions for equity classification. The debt discount is amortized to interest expense over the term of the 2027 Notes at an effective interest rate of 11.17% over the contractual terms of the 2027 Notes.

In accounting for the debt issuance costs of $0.4 million related to the 2027 Notes, the Company allocated the total amount incurred to the liability and equity components of the 2027 Notes based on their relative fair values. Issuance costs attributable to the liability component were $0.3 million and were amortized to interest expense using the effective interest method over the contractual terms of the 2027 Notes. Issuance costs attributable to the equity component were netted with the equity component in stockholders’ equity. As of January 1, 2022 the Company adopted ASU 2020-06, see Note 2 for the impact upon adoption to the 2027 Notes.

The net carrying amount of the liability component of the 2027 Notes was as follows (in thousands):

	September 30, 2022		December 31, 2021
Principal amount	$	200,000	$	200,000
Unamortized debt discount	(4,220)		(49,716)
Unamortized debt issuance cost	(284)		(246)
Net carrying amount	$	195,496	$	150,038

The net carrying amount of the equity component of the 2027 Notes was as follows (in thousands):

	September 30, 2022		December 31, 2021
Debt discount related to the value of conversion option	$	—	$	53,635
Debt issuance cost	—		(109)
Net carrying amount	$	—	$	53,526

The following table sets forth the interest expense recognized related to the 2027 Notes (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Contractual interest expense	$	2,500	$	2,500	$	7,500	$	7,472
Amortization of debt discount	197		1,606		582		4,713
Amortization of debt issuance cost	13		7		39		23
Total interest expense related to the 2027 Notes	$	2,710	$	4,113	$	8,121	$	12,208

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Licenses, Asset Acquisitions and Contingent Consideration

9 Months Ended

Sep. 30, 2022

Business Combinations [Abstract]

Licenses, Asset Acquisitions and Contingent Consideration

Licenses, Asset Acquisitions and Contingent Consideration

The following purchased assets were accounted for as asset acquisitions as substantially all of the fair value of the assets acquired were concentrated in a group of similar assets and/or the acquired assets were not capable of producing outputs due to the lack of employees and early stage of development. Because the assets had not yet received regulatory approval, the fair value attributable to these assets was recorded as in process research and development (“IPR&D”) expenses in the Company’s condensed consolidated statement of operations for the three and nine months ended September 30, 2022.

The Company accounts for contingent consideration payable upon achievement of certain regulatory, development or sales milestones in such asset acquisitions when the underlying contingency is met.

License from Pulmokine, Inc. (Seralutinib)

On October 2, 2017, the Company entered into a license agreement with Pulmokine, Inc. under which it was granted an exclusive worldwide license and sublicense to certain intellectual property rights owned or controlled by Pulmokine to develop and commercialize seralutinib and certain backup compounds for the treatment, prevention and diagnosis of any and all diseases or conditions. The Company also has the right to sublicense its rights under the license agreement, subject to certain conditions. The assets acquired are in the early stages of the FDA approval process, and the Company intends to further develop the assets acquired through potential FDA approval as evidenced by the milestone arrangement in the contract. The development activities cannot be performed without significant cost and effort by the Company. The agreement will remain in effect from the effective date, unless terminated earlier, until, on a licensed product-by-licensed product and country-by-country basis, the later of ten years from the date of first commercial sale or when there is no longer a valid patent claim covering such licensed product or specified regulatory exclusivity for the licensed product in such country. The Company is obligated to make future development and regulatory milestone payments of up to $58.0 million, commercial milestone payments of up to $45.0 million, and sales milestone payments of up to $190.0 million. The Company is also obligated to pay tiered royalties on sales for each licensed product, at percentages ranging from the mid-single digits to the high single-digits. In addition, if the Company chooses to sublicense or assign to any third parties its rights under the agreement with respect to a licensed product, or the Company’s seralutinib operating subsidiary undergoes a change of control, the Company must pay to Pulmokine a specified percentage of all revenue to be received in connection with such transaction. The Company made an upfront payment of $5.5 million in October 2017. In December 2020, the Company accrued a milestone payment of $5.0 million in connection with the initiation of the first Phase 2 clinical trial of seralutinib, which was paid in January 2021. As of September 30, 2022, no other milestones had been accrued as the underlying contingencies had not yet been met.

License from Aadi Biosciences, Inc. (GB004)

On June 24, 2018, the Company entered into a license agreement with Aerpio Pharmaceuticals, Inc., now known as Aadi Biosciences, Inc. ("Aadi"), under which the Company was granted an exclusive worldwide license and sublicense to certain intellectual property rights owned or controlled by Aadi to develop and commercialize GB004, and certain other related compounds for all applications. On July 24, 2022, the license agreement was terminated. As of September 30, 2022, no milestones had been accrued as the underlying contingencies had not yet been met.

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Stockholders' Equity

9 Months Ended

Sep. 30, 2022

Equity [Abstract]

Stockholders' Equity

Stockholders’ Equity

Common Stock

Each share of common stock is entitled to one vote. Common stock owners are entitled to dividends when funds are legally available and declared by the Board.

Private Placement Financing

On July 15, 2022, we completed a private placement of 16,649,365 shares of our common stock at purchase price of $7.21 per share. The gross proceeds for the private placement were approximately $120.1 million, before deducting offering expenses. On August 9, 2022, we filed a registration statement on Form S-3 registering the shares of common stock issued in the private placement, which registration statement became automatically effective on August 9, 2022.

Shares of Common Stock Subject to Repurchase

On December 3, 2015, the Company issued 9,160,888 shares of common stock as founder shares for services rendered to the Company, valued at $0.0001 par value per share, for a total of approximately $4,100 (the "founder shares"). On January 4,

2018, incremental vesting conditions were placed on the previously issued founder shares. Fifty percent of the previously issued founder shares vested on January 4, 2018, and the remaining founder shares are subject to vesting restrictions over a period of five years. These shares are subject to repurchase by the Company upon a founder's termination of employment or service to the Company.

Pursuant to the employment agreements with the Company’s founders executed January 4, 2018, the Company provided for certain potential additional issuances of common stock (the “anti-dilution shares”) to each of the founders to ensure the total number of shares of common stock held by them and their affiliates (inclusive of any shares subject to equity awards granted by the Company) would represent 15% of the Company’s fully-diluted capitalization until such time as the Company raised $300.0 million in equity capital, including the capital raised in the Series A financing.

In furtherance of this obligation, on May 21, 2018, the Company issued 251,547 shares of common stock to the founders for services rendered to the Company, valued at $2.61 per share with an additional 251,547 shares of restricted stock subject to the same vesting restrictions and vesting period as the founder shares. In addition, on September 6, 2018, the Company issued 1,795,023 shares of common stock to the founders for services rendered to the Company, valued at $9.63 per share, with an additional 1,795,023 shares of restricted stock subject to the same vesting restrictions and vesting period as the founder shares.

During the nine months ended September 30, 2022, no shares were forfeited due to termination of employment. During the year ended December 31, 2021, 25,383 shares were forfeited due to termination of employment. Any shares subject to repurchase by the Company are not deemed, for accounting purposes, to be outstanding until those shares vest. As such, the Company recognizes the measurement date fair value of the restricted stock over the vesting period as compensation expense. As of September 30, 2022 and December 31, 2021, 220,902 and 717,927 shares of common stock, respectively, were subject to repurchase by the Company. The unvested stock liability related to these awards is immaterial to all periods presented.

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Equity Incentive Plans

9 Months Ended

Sep. 30, 2022

Share-based Payment Arrangement [Abstract]

Equity Incentive Plans

Equity Incentive Plans

2019 Equity Incentive Plan

In January 2019, the Company’s board of directors and stockholders approved and adopted the 2019 Incentive Award Plan (the “2019 Plan”). The 2019 Plan became effective on February 6, 2019, the day prior to the effectiveness of the registration statement filed in connection with the IPO. Under the 2019 Plan, the Company may grant stock options, stock appreciation rights, restricted stock, restricted stock units, and other stock or cash-based awards to individuals who are then employees, officers, directors or consultants of the Company, and employees and consultants of the Company’s subsidiaries. A total of 5,750,000 shares of common stock were approved to be initially reserved for issuance under the 2019 Plan. The number of shares that remained available for issuance under the 2017 Plan (as defined below) as of the effective date of the 2019 Plan were, and shares subject to outstanding awards under the 2017 Plan as of the effective date of the 2019 Plan that are subsequently canceled, forfeited or repurchased by the Company will be, added to the shares reserved under the 2019 Plan. In addition, the number of shares of common stock available for issuance under the 2019 Plan will be automatically increased on the first day of each calendar year during the ten-year term of the 2019 Plan, beginning with January 1, 2020 and ending with January 1, 2029, by an amount equal to 5% of the outstanding number of shares of the Company’s common stock on December 31 of the preceding calendar year or such lesser amount as determined by the Company’s board of directors. As of September 30, 2022, an aggregate of 5,189,165 shares of common stock were available for issuance under the 2019 Plan. As of September 30, 2022 and December 31, 2021, 11,810,964 and 8,402,621 shares of common stock, respectively, were subject to outstanding awards under the 2019 Plan.

2019 Employee Stock Purchase Plan

In January 2019, the Company’s board of directors and stockholders approved and adopted the 2019 Employee Stock Purchase Plan (the “ESPP”). The ESPP became effective as of February 6, 2019, the day prior to the effectiveness of the registration statement filed in connection with the IPO. The ESPP permits participants to purchase common stock through payroll deductions of up to 20% of their eligible compensation. A total of 700,000 shares of common stock were approved to be initially reserved for issuance under the ESPP. In addition, the number of shares of common stock available for issuance under the ESPP will be automatically increased on the first day of each calendar year during the first ten years of the term of the ESPP, beginning with January 1, 2020 and ending with January 1, 2029, by an amount equal to 1% of the outstanding number of shares of the Company’s common stock on December 31 of the preceding calendar year or such lesser amount as determined by the Company’s board of directors. During the nine months ended September 30, 2022, 157,858 shares were issued pursuant to the ESPP. As of September 30, 2022, an aggregate of 2,450,855 shares of common stock were available for issuance under the ESPP.

2017 Equity Incentive Plan

The Company’s 2017 Equity Incentive Plan (the “2017 Plan”) permitted the granting of incentive stock options, non-statutory stock options, restricted stock, restricted stock units and other stock-based awards. Subsequent to the adoption of the 2019 Plan, no additional equity awards can be made under the 2017 Plan. As of September 30, 2022 and December 31, 2021, 2,614,198 and 2,875,330 shares of common stock, respectively, were subject to outstanding options under the 2017 Plan. As of September 30, 2022, no shares of restricted stock awards granted under the 2017 Plan were unvested.

Stock Options

The fair value of each employee and non-employee stock option grant is estimated on the date of grant using the Black-Scholes option-pricing model. The Company uses its own volatility to the extent it has sufficient trading history, and for awards in which sufficient trading history is not available, a peer group is used. Due to the lack of historical exercise history, the expected term of the Company’s stock options for employees has been determined utilizing the “simplified” method for awards. The expected term of stock options granted to non-employees is equal to the contractual term of the option award. The risk-free interest rate is determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award for time periods approximately equal to the expected term of the award. Expected dividend yield is zero based on the fact that the Company has never paid cash dividends and does not expect to pay any cash dividends in the foreseeable future.

The following table summarizes stock option activity during the nine months ended September 30, 2022:

	Shares Subject to Options Outstanding			Weighted- Average
	Shares	Weighted- Average Exercise Price		Remaining Contractual Life (Years)	Aggregate Intrinsic Value
					(in thousands)
Outstanding as of December 31, 2021	9,434,660	$	12.24	7.4	$	15,822
Options granted	4,447,720	$	11.50
Options exercised	(269,103)	$	6.40
Options forfeited/cancelled	(823,901)	$	15.77
Outstanding as of September 30, 2022	12,789,376	$	11.89	7.6	$	19,765
Options vested and expected to vest as of September 30, 2022	12,789,376	$	11.89	7.6	$	19,765
Options exercisable as of September 30, 2022	6,115,757	$	12.17	6.4	$	14,169

The aggregate intrinsic value in the above table is calculated as the difference between fair value of the Company’s common stock price on September 30, 2022 and the exercise price of the stock options. The aggregate intrinsic value of stock options exercised during nine months ended September 30, 2022 and 2021 was $1.5 million and $0.7 million, respectively.

The weighted-average grant date fair value per share for the stock option grants during the nine months ended September 30, 2022 and 2021 was $8.27 and $6.85, respectively.

The aggregate fair value of stock options that vested during the nine months ended September 30, 2022 and 2021 was $26.1 million and $17.3 million, respectively.

Restricted Stock

The summary of the Company’s restricted stock activity during the nine months ended September 30, 2022 is as follows:

	Number of Restricted Stock Units Outstanding	Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2021	2,561,219	$	8.67
Granted	572,901	11.94
Vested	(1,087,210)	7.72
Forfeited	(190,222)	10.67
Nonvested at September 30, 2022	1,856,688	$	10.04

At September 30, 2022, the total unrecognized compensation related to unvested restricted stock awards granted was $10.1 million, which the Company expects to recognize over a weighted-average period of approximately 0.9 years.

Stock-Based Compensation Expense

Stock-based compensation expense has been reported in the Company’s condensed consolidated statements of operations and comprehensive loss as follows (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Research and development	$	5,595	$	4,349	$	17,800	$	14,435
General and administrative	4,527		3,238		13,304		9,914
Total stock-based compensation expense	$	10,122	$	7,587	$	31,104	$	24,349

As of September 30, 2022, the total unrecognized compensation related to unvested stock option awards granted was $46.1 million, which the Company expects to recognize over a weighted-average period of approximately 2.1 years.

As of September 30, 2022, the total unrecognized compensation expense related to the ESPP was $1.6 million, which the Company expects to recognize over a weighted-average period of approximately 0.9 years.

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Commitments and Contingencies

9 Months Ended

Sep. 30, 2022

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

Commitments and Contingencies

Leases

The Company subleases certain office and laboratory space under a non-cancelable operating lease expiring in January 2025 for the initial leased space and for the expansion space leased pursuant to an amendment to the lease agreement entered into in August 2018. In February 2022, the Company exercised its renewal option to extend the term of the expansion space until January 2025. The sublease agreement included options to extend for the entire premises through October 2028. The options to extend must be exercised prior to the termination of the original lease agreement. The period covered by the options was not included in the non-cancellable lease term as it was not determined to be reasonably certain to be executed. The lease is subject to charges for common area maintenance and other costs, and base rent is subject to an annual 3% increase each subsequent year. Costs determined to be variable and not based on an index or rate were not included in the measurement of the operating lease liabilities.

Monthly rent expense is recognized on a straight-line basis over the term of the leases. The operating leases are included in the condensed consolidated balance sheets at the present value of the lease payments at a weighted average discount rate of 7% using the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment as the leases do not provide an implicit rate. The weighted average remaining lease term was 2.3 years.

Lease costs were comprised of the following (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Operating lease cost	$	778	$	1,008	$	2,318	$	3,084
Short-term lease cost	12		13		32		34
Total lease cost	$	790	$	1,021	$	2,350	$	3,118

Cash paid for amounts included in the measurement of operating lease liabilities for the three months ended September 30, 2022 and 2021 was $0.5 million and $1.0 million, respectively, and cash paid for amounts included in the measurement of operating lease liabilities for the nine months ended September 30, 2022 and 2021 was $2.4 million and $3.2 million, respectively.

Gross future minimum annual rental commitments as of September 30, 2022, were as follows (in thousands):

	Undiscounted Rent Payments
Year ending December 31
2022 (remaining 3 months)	$	806
2023	3,319
2024	3,419
2025	144
Total undiscounted rent payments	$	7,688
Present value discount	(569)
Present value of lease payments	$	7,119
Current portion of operating lease liabilities (included as a component of accrued expenses and other current liabilities)	2,907
Noncurrent operating lease liabilities	4,212
Total operating lease liability	$	7,119

For the three months ended September 30, 2022 and 2021 the Company recorded approximately $0.8 million and $1.1 million, respectively, in rent expense. For the nine months ended September 30, 2022 and 2021, the Company recorded approximately $2.5 million and $3.3 million, respectively, in rent expense.

Litigation

Kuhne vs. Gossamer Bio, Inc., et. al.

On April 3, 2020, Scott Kuhne, individually and on behalf of all others similarly situated, filed a putative class action lawsuit against the Company, certain of its executive officers and directors, and the underwriters of its IPO in the United States District Court for the Southern District of California (Case No. 3:20-cv-00649-DMS-DEB). The second amended complaint was filed on November 20, 2020. The complaint was filed on behalf of all investors who purchased the Company's securities pursuant to or traceable to the Company's February 8, 2019 IPO. The complaint alleged that the Company, certain of its executive officers and directors, and the underwriters of its IPO made false and/or misleading statements and failed to disclose material adverse facts about its business, operations and prospects in violation of Sections 11 and 15 of the Securities Act of 1933, as amended. The plaintiff sought damages, interest, costs, attorneys’ fees, and other unspecified equitable relief. The Company moved to dismiss the complaint on January 19, 2021. On April 19, 2021, the Court granted the Company's motion to dismiss in substantial part without leave to amend, and denied the motion to dismiss as to a single claim. On October 29, 2021, the parties informed the Court that they had reached a settlement in principle, and the Court vacated all deadlines. The parties entered a settlement agreement on February 1, 2022. Pursuant to the agreement, the Company paid approximately $2.4 million, in exchange for customary releases and settlement terms. The Court entered an order preliminarily approving the settlement on March 14, 2022, and the final settlement approval hearing was held on September 30, 2022. The Court subsequently entered orders approving the lead plaintiff’s requested plan of allocation for the settlement fund and request for attorneys’ fees and reimbursement of litigation expenses. The Court entered a judgment approving the class action settlement on September 30, 2022. In accordance with the authoritative guidance on the evaluation of loss contingencies, the Company recorded a $2.4 million litigation charge related to this matter for the year ended December 31, 2021, which was included as a component of accrued expenses and other current liabilities on the Consolidated Balance Sheet for the year ended December 31, 2021.

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Summary of Significant Accounting Policies (Policies)

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Basis of Presentation

Basis of PresentationThe accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) for interim financial information and with the instructions of the Securities and Exchange Commission (“SEC”) on Form 10-Q and Rule 10-01 of Regulation S-X. Accordingly, they do not include all of the information and disclosures required by GAAP for complete financial statements. In the opinion of management, the condensed consolidated financial statements include all adjustments necessary, which are of a normal and recurring nature, for the fair presentation of the Company’s financial position and of the results of operations and cash flows for the periods presented. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto for the year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 3, 2022. The results of operations for the interim period shown in this report are not necessarily indicative of the results that may be expected for any other interim period or for the full year. The balance sheet at December 31, 2021, has been derived from the audited financial statements at that date.

Use of Estimates

Use of Estimates

The preparation of condensed consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the condensed consolidated financial statements and the reported amounts of expenses during the reporting period. The most significant estimates in the Company’s condensed consolidated financial statements relate to the allocation of the 2027 Notes into liability and equity components and accrued research and development expenses. These estimates and assumptions are based on current facts, historical experience and various other factors believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities and the recording of expenses that are not readily apparent from other sources. Actual results could differ from those estimates.

Recent Accounting Pronouncements - Adopted

Recent Accounting Pronouncements - Adopted

In August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2020-06, Debt: Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity's Own Equity (Subtopic 815-40) (“ASU 2020-06”), which simplifies the accounting for convertible instruments and contracts in an entity's own equity. This guidance is effective for annual reporting periods beginning after December 15, 2021, including interim periods within those years, with early adoption permitted only as of annual reporting periods beginning after December 15, 2020.

The Company adopted ASU 2020-06 on January 1, 2022 using the modified retrospective approach, and accordingly the Company recorded an adjustment that reflects the 2027 Notes as if the embedded conversion feature had not been separated. The impact upon adoption on the Consolidated Balance Sheets was an increase of $44.8 million in convertible senior notes, net, a write-off of $9.4 million in deferred income tax liabilities and a decrease of $53.5 million in additional paid-in capital. In addition, upon adoption, there was an adjustment of $8.7 million to increase the beginning balance of accumulated deficit on the Consolidated Balance Sheets for previously recognized interest expense related to amortization of debt discount related to the carrying value of the embedded conversion feature upon issuance. There was no impact to the Company’s net loss per share calculation. See Note 5 "Indebtedness" for further information regarding the 2027 Notes.

Net Loss Per Share

Net Loss Per Share

Basic net loss per share of common stock is computed by dividing net loss attributable to common stockholders by the weighted average number of shares of common stock outstanding for the period. The Company uses the if-converted method for assumed conversion of the 2027 Notes to compute the weighted average shares of common stock outstanding for diluted net loss per share. Diluted net loss per share excludes the potential impact of the Company’s common stock options and unvested shares of restricted stock and the potential shares issuable upon conversion of the 2027 Notes because their effect would be anti-dilutive due to the Company’s net loss. Since the Company had a net loss in each of the periods presented, basic and diluted net loss per common share are the same.

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Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2022

Accounting Policies [Abstract]

Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Net Loss Per Share

The table below provides potentially dilutive securities not included in the calculation of the diluted net loss per share because to do so would be anti-dilutive:

	As of September 30,
	2022	2021
2027 Notes	12,321,900	12,321,900
Shares issuable upon exercise of stock options	12,789,376	9,540,332
Non-vested shares under restricted stock grants	1,856,688	3,020,509
Total potentially dilutive securities	26,967,964	24,882,741

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Balance Sheet Accounts and Supplemental Disclosures (Tables)

9 Months Ended

Sep. 30, 2022

Balance Sheets Accounts And Supplemental Disclosures [Abstract]

Schedule of Property and Equipment, Net

Property and equipment, net consisted of the following (in thousands):

	Estimated Useful Life (in years)	September 30, 2022		December 31, 2021
Office equipment	3-7	$	1,097	$	1,097
Computer equipment	5	123		123
Software	3	130		130
Lab equipment	2-5	6,044		5,688
Leasehold improvements	6-7	2,562		2,562
Total property and equipment		9,956		9,600
Less: accumulated depreciation		5,651		4,280
Property and equipment, net		$	4,305	$	5,320

Schedule of Accrued Expenses

Accrued expenses and other current liabilities consisted of the following (in thousands):

	As of
	September 30, 2022		December 31, 2021
Accrued compensation and benefits	$	10,501	$	11,916
Operating lease liabilities	2,907		2,902
Debt, current	11,613		—
Accrued consulting fees	1,433		956
Accrued interest	3,549		1,066
Accrued legal fees	251		202
Accrued litigation liability	—		2,375
Accrued accounting fees	429		154
Accrued other	853		839
Total accrued expenses and other current liabilities	$	31,536	$	20,410

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Fair Value Measurements and Available for Sale Investments (Tables)

9 Months Ended

Sep. 30, 2022

Fair Value Measurements And Available For Sale Investments [Abstract]

Assets Measured at Fair Value on Recurring Basis

The following table presents the hierarchy for assets measured at fair value on a recurring basis as of September 30, 2022 and December 31, 2021 (in thousands):

	Fair Value Measurements at End of Period Using:
	Total Fair Value		Quoted Market Prices for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
As of September 30, 2022
Money market funds	$	81,850	$	81,850	$	—	$	—
U.S. Treasury and agency securities	58,883		58,883		—		—
Commercial paper	119,603		—		119,603		—
Corporate debt securities	12,347		—		12,347		—
As of December 31, 2021
Money market funds	$	139,794	$	139,794	$	—	$	—
Commercial paper	113,939		—		113,939		—
Corporate debt securities	37,873		—		37,873		—

Schedule of Available for Sale Investments by Security Type

The aggregate market value, cost basis, and gross unrealized losses of available-for-sale investments by security type, classified in marketable securities and long-term investments as of September 30, 2022 and December 31, 2021 are as follows (in thousands):

	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses		Total Fair Value
As of September 30, 2022
U.S. Treasury and agency securities	$	41,494	$	—	$	(79)	$	41,415
Corporate debt securities	12,426		—		(79)		12,347
Commercial paper	97,345		—		(201)		97,144
Total marketable securities	$	151,265	$	—	$	(359)	$	150,906
As of December 31, 2021
Corporate debt securities	$	37,921	$	—	$	(48)	$	37,873
Commercial paper	103,942		—		—		103,942
Total marketable securities	$	141,863	$	—	$	(48)	$	141,815

Schedule of Contractual Maturities of Available-for-sale Debt Securities

Contractual maturities of available-for-sale debt securities, as of September 30, 2022, were as follows (in thousands):

	Estimated  Fair Value
Less than one year	$	150,906
Greater than one year	—
Total	$	150,906

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Indebtedness (Tables)

9 Months Ended

Sep. 30, 2022

Debt Disclosure [Abstract]

Schedule of Long-term Debt

Debt consisted of the following (in thousands):

	September 30, 2022		December 31, 2021
Debt, current portion	$	11,613	$	—
Debt, non-current portion	15,484		30,000
Total debt	27,097		30,000
Less: unamortized debt discount and issuance costs	(650)		(921)
Debt, net	$	26,447	$	29,079

Schedule of Future Minimum Principal Payments

The scheduled future minimum principal payments are as follows (in thousands):

	September 30, 2022
2022 (remaining 3 months)	$	2,903
2023	11,613
2024	11,613
2025	968
Total	$	27,097

Schedule of Net Carrying Amount of Liability Component

The net carrying amount of the liability component of the 2027 Notes was as follows (in thousands):

	September 30, 2022		December 31, 2021
Principal amount	$	200,000	$	200,000
Unamortized debt discount	(4,220)		(49,716)
Unamortized debt issuance cost	(284)		(246)
Net carrying amount	$	195,496	$	150,038

Schedule of Equity Components

The net carrying amount of the equity component of the 2027 Notes was as follows (in thousands):

	September 30, 2022		December 31, 2021
Debt discount related to the value of conversion option	$	—	$	53,635
Debt issuance cost	—		(109)
Net carrying amount	$	—	$	53,526

Schedule of Interest Expense Recognized

The following table sets forth the interest expense recognized related to the 2027 Notes (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Contractual interest expense	$	2,500	$	2,500	$	7,500	$	7,472
Amortization of debt discount	197		1,606		582		4,713
Amortization of debt issuance cost	13		7		39		23
Total interest expense related to the 2027 Notes	$	2,710	$	4,113	$	8,121	$	12,208

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Equity Incentive Plans (Tables)

9 Months Ended

Sep. 30, 2022

Share-based Payment Arrangement [Abstract]

Summary of Stock Option Activity

The following table summarizes stock option activity during the nine months ended September 30, 2022:

	Shares Subject to Options Outstanding			Weighted- Average
	Shares	Weighted- Average Exercise Price		Remaining Contractual Life (Years)	Aggregate Intrinsic Value
					(in thousands)
Outstanding as of December 31, 2021	9,434,660	$	12.24	7.4	$	15,822
Options granted	4,447,720	$	11.50
Options exercised	(269,103)	$	6.40
Options forfeited/cancelled	(823,901)	$	15.77
Outstanding as of September 30, 2022	12,789,376	$	11.89	7.6	$	19,765
Options vested and expected to vest as of September 30, 2022	12,789,376	$	11.89	7.6	$	19,765
Options exercisable as of September 30, 2022	6,115,757	$	12.17	6.4	$	14,169

Summary of Restricted Stock Activity

The summary of the Company’s restricted stock activity during the nine months ended September 30, 2022 is as follows:

	Number of Restricted Stock Units Outstanding	Weighted- Average Grant Date Fair Value
Nonvested at December 31, 2021	2,561,219	$	8.67
Granted	572,901	11.94
Vested	(1,087,210)	7.72
Forfeited	(190,222)	10.67
Nonvested at September 30, 2022	1,856,688	$	10.04

Stock-Based Compensation Expense Reported in Condensed Consolidated Statements of Operations

Stock-based compensation expense has been reported in the Company’s condensed consolidated statements of operations and comprehensive loss as follows (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Research and development	$	5,595	$	4,349	$	17,800	$	14,435
General and administrative	4,527		3,238		13,304		9,914
Total stock-based compensation expense	$	10,122	$	7,587	$	31,104	$	24,349

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Commitments and Contingencies (Tables)

9 Months Ended

Sep. 30, 2022

Commitments and Contingencies Disclosure [Abstract]

Schedule of Lease Costs

Lease costs were comprised of the following (in thousands):

	Three months ended September 30,				Nine months ended September 30,
	2022		2021		2022		2021
Operating lease cost	$	778	$	1,008	$	2,318	$	3,084
Short-term lease cost	12		13		32		34
Total lease cost	$	790	$	1,021	$	2,350	$	3,118

Schedule of Gross Future Minimum Annual Rental Commitments

Gross future minimum annual rental commitments as of September 30, 2022, were as follows (in thousands):

	Undiscounted Rent Payments
Year ending December 31
2022 (remaining 3 months)	$	806
2023	3,319
2024	3,419
2025	144
Total undiscounted rent payments	$	7,688
Present value discount	(569)
Present value of lease payments	$	7,119
Current portion of operating lease liabilities (included as a component of accrued expenses and other current liabilities)	2,907
Noncurrent operating lease liabilities	4,212
Total operating lease liability	$	7,119

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Description of the Business - Additional Information (Detail) - USD ($) $ in Thousands	60 Months Ended
	Sep. 30, 2022	Dec. 31, 2021
Accounting Policies [Abstract]
Accumulated deficit	$ 976,459	$ 811,534
Funds raised through Series A and Series B Convertible Preferred Stock, convertible note financings and completed IPO	$ 1,062,100

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Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Sep. 30, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Long-term convertible senior notes	$ 195,496			$ 150,038
Increase (decrease) in stockholders' equity	56,351	$ (16,461)	$ 30,159	121,463	$ 169,809	$ 220,693	$ 272,084	$ 320,684
Additional paid-in capital
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity	1,033,385	901,141	891,121	932,944	924,914	915,414	907,089	897,607
Accumulated deficit
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity	$ (976,459)	$ (917,096)	$ (860,630)	(811,534)	$ (755,250)	$ (695,003)	$ (635,171)	$ (577,530)
Cumulative Effect, Period of Adoption, Adjustment
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Long-term convertible senior notes				44,800
Write-off of deferred tax liabilities				9,400
Increase (decrease) in stockholders' equity				(44,838)
Cumulative Effect, Period of Adoption, Adjustment | Additional paid-in capital
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity				(53,527)
Cumulative Effect, Period of Adoption, Adjustment | Accumulated deficit
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Increase (decrease) in stockholders' equity				$ 8,689

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Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Net Loss Per Share (Details) - shares	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities not included from calculation of diluted net loss per share (in shares)	26,967,964	24,882,741
2027 Notes
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities not included from calculation of diluted net loss per share (in shares)	12,321,900	12,321,900
Shares issuable upon exercise of stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities not included from calculation of diluted net loss per share (in shares)	12,789,376	9,540,332
Non-vested shares under restricted stock grants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities not included from calculation of diluted net loss per share (in shares)	1,856,688	3,020,509

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Balance Sheet Accounts and Supplemental Disclosures - Schedule of Property and Equipment, Net (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Total property and equipment	$ 9,956		$ 9,956		$ 9,600
Less: accumulated depreciation	5,651		5,651		4,280
Property and equipment, net	4,305		4,305		5,320
Depreciation and amortization expense	500	$ 500	1,372	$ 1,292
Office equipment
Property, Plant and Equipment [Line Items]
Total property and equipment	1,097		$ 1,097		1,097
Office equipment | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			3 years
Office equipment | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			7 years
Computer equipment
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			5 years
Total property and equipment	123		$ 123		123
Software
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			3 years
Total property and equipment	130		$ 130		130
Lab equipment
Property, Plant and Equipment [Line Items]
Total property and equipment	6,044		$ 6,044		5,688
Lab equipment | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			2 years
Lab equipment | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			5 years
Leasehold improvements
Property, Plant and Equipment [Line Items]
Total property and equipment	$ 2,562		$ 2,562		$ 2,562
Leasehold improvements | Minimum
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			6 years
Leasehold improvements | Maximum
Property, Plant and Equipment [Line Items]
Estimated Useful Life (in years)			7 years

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Balance Sheet Accounts and Supplemental Disclosures - Schedule of Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Balance Sheets Accounts And Supplemental Disclosures [Abstract]
Accrued compensation and benefits	$ 10,501	$ 11,916
Operating lease liabilities	2,907	2,902
Debt, current	11,613	0
Accrued consulting fees	1,433	956
Accrued interest	3,549	1,066
Accrued legal fees	251	202
Accrued litigation liability	0	2,375
Accrued accounting fees	429	154
Accrued other	853	839
Total accrued expenses and other current liabilities	$ 31,536	$ 20,410

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Fair Value Measurements and Available for Sale Investments - Assets Measured at Fair Value on Recurring Basis (Details) - Recurring Basis - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	$ 81,850	$ 139,794
U.S. Treasury and agency securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	58,883
Commercial paper
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	119,603	113,939
Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	12,347	37,873
Quoted Market Prices for Identical Assets (Level 1) | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	81,850	139,794
Quoted Market Prices for Identical Assets (Level 1) | U.S. Treasury and agency securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	58,883
Quoted Market Prices for Identical Assets (Level 1) | Commercial paper
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0	0
Quoted Market Prices for Identical Assets (Level 1) | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0	0
Significant Other Observable Inputs (Level 2) | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0	0
Significant Other Observable Inputs (Level 2) | U.S. Treasury and agency securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0
Significant Other Observable Inputs (Level 2) | Commercial paper
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	119,603	113,939
Significant Other Observable Inputs (Level 2) | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	12,347	37,873
Significant Unobservable Inputs (Level 3) | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0	0
Significant Unobservable Inputs (Level 3) | U.S. Treasury and agency securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0
Significant Unobservable Inputs (Level 3) | Commercial paper
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	0	0
Significant Unobservable Inputs (Level 3) | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Assets measured at fair value on recurring basis	$ 0	$ 0

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Fair Value Measurements and Available for Sale Investments - Additional Information (Details) - USD ($) $ in Millions	Sep. 30, 2022	Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents, at carrying value	$ 39.9	$ 10.0
2027 Notes | Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of convertible senior notes	227.5	190.5
Prepaid Expenses and Other Current Assets
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Interest and securities receivable	$ 0.1	$ 0.2

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Fair Value Measurements and Available for Sale Investments - Schedule of Available for sale Investments by Security Type (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Amortized Cost	$ 151,265	$ 141,863
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(359)	(48)
Total Fair Value	150,906	141,815
U.S. Treasury and agency securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Amortized Cost	41,494
Gross Unrealized Gains	0
Gross Unrealized Losses	(79)
Total Fair Value	41,415
Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Amortized Cost	12,426	37,921
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(79)	(48)
Total Fair Value	12,347	37,873
Commercial paper
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Amortized Cost	97,345	103,942
Gross Unrealized Gains	0	0
Gross Unrealized Losses	(201)	0
Total Fair Value	$ 97,144	$ 103,942

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Fair Value Measurements and Available for Sale Investments - Schedule of Contractual Maturities of Available-for-sale Debt Securities (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Fair Value Measurements And Available For Sale Investments [Abstract]
Less than one year	$ 150,906
Greater than one year	0
Total	$ 150,906	$ 141,815

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Indebtedness - Additional Information (Details)			9 Months Ended
	May 21, 2020 USD ($) tradingDay $ / shares	May 02, 2019 USD ($) tranche	Sep. 30, 2022 USD ($) tranche
Term Loan | Credit Facility
Debt Instrument [Line Items]
Maximum borrowing capacity		$ 150,000,000
Amount funded		30,000,000
Remaining borrowing capacity		$ 120,000,000
Number of additional tranches | tranche		2
Clinical development milestone unmet, number of tranches | tranche			1
Percentage of exit fee on amount borrowed on final repayment		1.75%
Percentage of exit fee on amount borrowed on partial prepayment		1.75%
Debt covenant minimum unrestricted cash percentage		25.00%
Debt instrument, default trigger amount			$ 2,500,000
Term Loan | Credit Facility | Prepayment Occurs through First Anniversary of Closing Date
Debt Instrument [Line Items]
Percentage of prepayment fee		3.00%
Term Loan | Credit Facility | First Anniversary of Closing Date through Second Anniversary of Closing Date
Debt Instrument [Line Items]
Percentage of prepayment fee		2.00%
Term Loan | Credit Facility | Second Anniversary of Closing Date and Prior to Jan 1, 2025
Debt Instrument [Line Items]
Percentage of prepayment fee		1.00%
Term Loan | Credit Facility | LIBOR
Debt Instrument [Line Items]
Basis spread on variable rate		7.00%
Interest rate		2.00%
Term Loan | Credit Facility | MidCap Financial Trust
Debt Instrument [Line Items]
Basis spread on variable rate			3.00%
Term Loan | Tranche One | Credit Facility
Debt Instrument [Line Items]
Remaining borrowing capacity		$ 60,000,000	$ 60,000,000
Term Loan | Tranche Two | Credit Facility
Debt Instrument [Line Items]
Remaining borrowing capacity		$ 60,000,000
2027 Notes
Debt Instrument [Line Items]
Interest rate	5.00%
Debt instrument aggregate principal amount	$ 200,000,000
Proceeds from convertible debt	$ 193,600,000
Debt instrument conversion ratio	0.0616
Convertible notes, initial conversion price (in dollars per share) | $ / shares	$ 16.23
Convertible notes, percentage of conversion price	130.00%
Debt conversion, converted instrument	$ 1,000
Convertible notes, redemption percentage	100.00%
Percentage of repurchase price is equal to principal amount of convertible notes	100.00%
Percentage in aggregate principal amount (not less than)	0.25
Carrying amount of the equity component	$ 53,500,000
Convertible notes, effective interest rate	11.17%
Debt issuance costs	$ 400,000
Amortization of debt issuance cost	$ 300,000
2027 Notes | Maximum
Debt Instrument [Line Items]
Convertible notes, percentage of last reported sale price of common stock	98.00%
2027 Notes | 130% Applicable Conversion Price | Minimum
Debt Instrument [Line Items]
Convertible notes, consecutive trading days | tradingDay	20
2027 Notes | 130% Applicable Conversion Price | Maximum
Debt Instrument [Line Items]
Convertible notes, consecutive trading days | tradingDay	30
2027 Notes | 98% Applicable Conversion Price | Minimum
Debt Instrument [Line Items]
Convertible notes, consecutive trading days | tradingDay	5
2027 Notes | 98% Applicable Conversion Price | Maximum
Debt Instrument [Line Items]
Convertible notes, consecutive trading days | tradingDay	10

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Indebtedness - Schedule of Long-term Debt (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Debt Instrument [Line Items]
Debt, non-current portion	$ 14,834	$ 29,079
Credit Facility
Debt Instrument [Line Items]
Debt, current portion	11,613	0
Debt, non-current portion	15,484	30,000
Total debt	27,097	30,000
Less: unamortized debt discount and issuance costs	(650)	(921)
Debt, net	$ 26,447	$ 29,079

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Indebtedness - Schedule of Future Minimum Principal Payments (Details) - Credit Facility $ in Thousands	Sep. 30, 2022 USD ($)
Debt Instrument [Line Items]
2022 (remaining 3 months)	$ 2,903
2023	11,613
2024	11,613
2025	968
Total debt	$ 27,097

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Indebtedness - Schedule of Net Carrying Amount of Liability Component (Details) - 2027 Notes - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Debt Instrument [Line Items]
Principal amount	$ 200,000	$ 200,000
Unamortized debt discount	(4,220)	(49,716)
Unamortized debt issuance cost	(284)	(246)
Debt, net	$ 195,496	$ 150,038

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Indebtedness - Schedule of Equity Components (Details) - 2027 Notes - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Debt Instrument [Line Items]
Debt discount related to the value of conversion option	$ 0	$ 53,635
Debt issuance cost	0	(109)
Net carrying amount	$ 0	$ 53,526

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Indebtedness - Schedule of Interest Expense Recognized (Details) - 2027 Notes - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Debt Instrument [Line Items]
Contractual interest expense	$ 2,500	$ 2,500	$ 7,500	$ 7,472
Amortization of debt discount	197	1,606	582	4,713
Amortization of debt issuance cost	13	7	39	23
Total interest expense related to the 2027 Notes	$ 2,710	$ 4,113	$ 8,121	$ 12,208

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Licenses, Asset Acquisitions and Contingent Consideration - Additional Information (Details) - License Agreement - USD ($)		1 Months Ended
	Oct. 02, 2017	Oct. 31, 2017	Sep. 30, 2022	Dec. 31, 2020
Pulmokine, Inc. | In Process Research And Development Seralutinib
Business Acquisition [Line Items]
Product license term (in years)	10 years
Upfront payment		$ 5,500,000
Milestones accrued			$ 0	$ 5,000,000
Pulmokine, Inc. | In Process Research And Development Seralutinib | Maximum
Business Acquisition [Line Items]
Development and regulatory milestone payments, payable	$ 58,000,000
Commercial milestone payments, payable	45,000,000
Sales milestone payments, payable	$ 190,000,000
Aerpio Pharmaceuticals, Inc. | In Process Research And Development G B Zero Zero Four
Business Acquisition [Line Items]
Milestones accrued			$ 0

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Stockholders' Equity - Additional Information (Details)						3 Months Ended	9 Months Ended		12 Months Ended
	Jul. 15, 2022 USD ($) $ / shares shares	Sep. 06, 2018 $ / shares shares	May 21, 2018 $ / shares shares	Jan. 04, 2018 USD ($)	Dec. 03, 2015 USD ($) $ / shares shares	Sep. 30, 2022 USD ($) $ / shares shares	Sep. 30, 2022 vote $ / shares shares	Sep. 30, 2021 shares	Dec. 31, 2021 $ / shares shares
Stockholders Equity [Line Items]
Common stock number of votes per share | vote							1
Common stock, par value (in dollars per share) | $ / shares						$ 0.0001	$ 0.0001		$ 0.0001
Issuance of common stock in connection with a public offering net of underwriting discounts, commissions and offering costs | $						$ 119,928,000
Shares subject to forfeiture (in shares)								0	25,383
Shares of common stock, repurchase (in shares)						220,902	220,902		717,927
Private Placement
Stockholders Equity [Line Items]
Private placement, number of shares	16,649,365
Offering price (in dollars per share) | $ / shares	$ 7.21
Aggregate gross proceeds | $	$ 120,100,000
Founder
Stockholders Equity [Line Items]
Issuance of common stock in connection with a private offering, net of offering costs of $184		1,795,023	251,547
Percentage of fully diluted share capital				15.00%
Increased in equity capital amount | $				$ 300,000,000
Common stock issued price per share (in USD per share) | $ / shares		$ 9.63	$ 2.61
Additional shares of restricted stock subject to vesting restrictions (in shares)		1,795,023	251,547
Founder Shares
Stockholders Equity [Line Items]
Issuance of common stock in connection with a private offering, net of offering costs of $184					9,160,888
Common stock, par value (in dollars per share) | $ / shares					$ 0.0001
Issuance of common stock in connection with a public offering net of underwriting discounts, commissions and offering costs | $					$ 4,100
Common Stock vesting percentage				50.00%
Common stock vesting period (in years)				5 years

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Equity Incentive Plans - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions		9 Months Ended
	Feb. 06, 2019	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares outstanding awarded (in shares)		12,789,376		9,434,660
Restricted Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation costs		$ 10.1
Weighted-average period of cost expects to recognize (in years)		10 months 24 days
Stock Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected dividend yield (as a percent)		0.00%
Aggregate intrinsic value, options vested in period		$ 1.5	$ 0.7
Weighted-average grant date fair value (in dollars per share)		$ 8.27	$ 6.85
Aggregate fair value of stock options vested during period		$ 26.1	$ 17.3
Stock-Based Compensation Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted-average period of cost expects to recognize (in years)		2 years 1 month 6 days
Unrecognized compensation expense		$ 46.1
2019 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares reserved for future issuance (in shares)	5,750,000
Term of awards (in years)	10 years
Percentage of amount increase in outstanding shares	5.00%
Common stock available for issuance (in shares)		5,189,165
Shares outstanding awarded (in shares)		11,810,964		8,402,621
2019 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares reserved for future issuance (in shares)	700,000
Term of awards (in years)	10 years
Percentage of amount increase in outstanding shares	1.00%
Common stock available for issuance (in shares)		2,450,855
Number of share issued under ESPP		157,858
2019 Employee Stock Purchase Plan | Stock-Based Compensation Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Weighted-average period of cost expects to recognize (in years)		10 months 24 days
Unrecognized compensation expense		$ 1.6
2019 Employee Stock Purchase Plan | Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Purchase of common stock through payroll deductions, percentage	20.00%
2017 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares outstanding awarded (in shares)		2,614,198		2,875,330
2017 Equity Incentive Plan | Restricted Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock awards granted (in shares)		0

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Equity Incentive Plans - Summary of Stock Option Activity (Details) $ / shares in Units, $ in Thousands	9 Months Ended	12 Months Ended
	Sep. 30, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares
Shares Subject to Options Outstanding, Shares
Outstanding as of beginning balance (in shares) | shares	9,434,660
Options granted (in shares) | shares	4,447,720
Option exercised (in shares) | shares	(269,103)
Options forfeited/cancelled (in shares) | shares	(823,901)
Outstanding as ending balance (in shares) | shares	12,789,376	9,434,660
Options vested and exercisable as of ending balance (in shares) | shares	12,789,376
Options exercisable as of ending balance (in shares) | shares	6,115,757
Shares Subject to Options Outstanding, Weighted Average Exercise Price
Outstanding as of beginning balance (in USD per share) | $ / shares	$ 12.24
Options granted (in USD per share) | $ / shares	11.50
Option exercised (in USD per share) | $ / shares	6.40
Options forfeited/cancelled (in USD per share) | $ / shares	15.77
Outstanding as of ending balance (in USD per share) | $ / shares	11.89	$ 12.24
Options vested and exercisable as of ending balance (in USD per share) | $ / shares	11.89
Options exercisable as of ending balance (in USD per share) | $ / shares	$ 12.17
Weighted-Average Remaining Contractual Life (in years)	7 years 7 months 6 days	7 years 4 months 24 days
Weighted-Average Remaining Contractual Life (in years), Options vested and exercisable as of end of period	7 years 7 months 6 days
Weighted-Average Remaining Contractual Life (in years), Options exercisable as of end of period	6 years 4 months 24 days
Aggregate Intrinsic Value | $	$ 19,765	$ 15,822
Aggregate Intrinsic Value, Options vested and exercisable as of end of period | $	19,765
Aggregate Intrinsic Value, Options exercisable as of end of period | $	$ 14,169

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Equity Incentive Plans - Summary of Restricted Stock Activity (Details) - Restricted Stock	9 Months Ended
	Sep. 30, 2022 $ / shares shares
Number of Restricted Stock Units Outstanding
Nonvested beginning balance (in shares) | shares	2,561,219
Granted (in shares) | shares	572,901
Vested (in shares) | shares	(1,087,210)
Forfeited (in shares) | shares	(190,222)
Nonvested ending balance (in shares) | shares	1,856,688
Weighted- Average Grant Date Fair Value
Nonvested beginning balance (in USD per share) | $ / shares	$ 8.67
Granted (in USD per share) | $ / shares	11.94
Vested (in USD per share) | $ / shares	7.72
Forfeited (in USD per share) | $ / shares	10.67
Nonvested ending balance (in USD per share) | $ / shares	$ 10.04

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Equity Incentive Plans - Stock-Based Compensation Expense Reported in Condensed Consolidated Statements of Operations (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	$ 10,122	$ 7,587	$ 31,104	$ 24,349
Research and development
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	5,595	4,349	17,800	14,435
General and administrative
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total stock-based compensation expense	$ 4,527	$ 3,238	$ 13,304	$ 9,914

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Commitments and Contingencies - Additional Information (Details) - USD ($) $ in Millions		3 Months Ended		9 Months Ended
	Oct. 29, 2021	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Lessee, Lease, Description [Line Items]
Operating lease, weighted average discount rate		7.00%		7.00%
Weighted average remaining lease term (in years)		2 years 3 months 18 days		2 years 3 months 18 days
Cash paid for operating lease liabilities		$ 0.5	$ 1.0	$ 2.4	$ 3.2
Rent expense		$ 0.8	$ 1.1	$ 2.5	$ 3.3
Litigation charge	$ 2.4
Non-cancelable Lease Agreement Entered in August 2018
Lessee, Lease, Description [Line Items]
Operating sublease, annual increase percentage for base rent				3.00%

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Commitments and Contingencies - Schedule of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Commitments and Contingencies Disclosure [Abstract]
Operating lease cost	$ 778	$ 1,008	$ 2,318	$ 3,084
Short-term lease cost	12	13	32	34
Total lease cost	$ 790	$ 1,021	$ 2,350	$ 3,118

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Commitments and Contingencies - Schedule of Gross Future Minimum Annual Rental Commitments (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Commitments and Contingencies Disclosure [Abstract]
2022 (remaining 3 months)	$ 806
2023	3,319
2024	3,419
2025	144
Total undiscounted rent payments	7,688
Present value discount	(569)
Present value of lease payments	7,119
Current portion of operating lease liabilities (included as a component of accrued expenses and other current liabilities)	2,907	$ 2,902
Noncurrent operating lease liabilities	4,212	$ 3,218
Total operating lease liability	$ 7,119