Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Long-term convertible senior notes	$ 195,286		$ 150,038
Stockholders' equity	(16,461)	$ 30,159	121,463	$ 220,693	$ 272,084	$ 320,684
Additional paid-in capital
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Stockholders' equity	901,141	891,121	932,944	915,414	907,089	897,607
Accumulated deficit
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Stockholders' equity	$ (917,096)	$ (860,630)	(811,534)	$ (695,003)	$ (635,171)	$ (577,530)
Cumulative Effect, Period of Adoption, Adjustment
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Long-term convertible senior notes			44,800
Deferred tax liabilities			9,400
Stockholders' equity			(44,838)
Cumulative Effect, Period of Adoption, Adjustment | Additional paid-in capital
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Stockholders' equity			(53,527)
Cumulative Effect, Period of Adoption, Adjustment | Accumulated deficit
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Stockholders' equity			$ 8,689