Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 138,907	$ 183,403
Marketable securities	132,716	141,815
Restricted cash	64	64
Prepaid expenses and other current assets	9,087	6,498
Total current assets	280,774	331,780
Property and equipment, net	5,025	5,320
Operating lease right-of-use assets	7,861	5,477
Other assets	1,019	1,080
Total assets	294,679	343,657
Current liabilities
Accounts payable	592	3,244
Accrued research and development expenses	16,958	16,205
Accrued expenses and other current liabilities	17,018	20,410
Total current liabilities	34,568	39,859
Long-term convertible senior notes	195,079	150,038
Long-term debt	29,167	29,079
Operating lease liabilities - long-term	5,706	3,218
Total liabilities	264,520	222,194
Commitments and contingencies (Note 9)
Stockholders' equity
Common stock, $0.0001 par value; 700,000,000 shares authorized as of March 31, 2022 and December 31, 2021; 77,106,185 shares issued and 76,553,937 shares outstanding as of March 31, 2022, and 76,470,588 shares issued and 75,752,664 shares outstanding as of December 31, 2021	8	8
Additional paid-in capital	891,121	932,944
Accumulated deficit	(860,630)	(811,534)
Accumulated other comprehensive (loss) income	(340)	45
Total stockholders' equity	30,159	121,463
Total liabilities and stockholders' equity	$ 294,679	$ 343,657