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Description of the Business - Additional Information (Detail) - USD ($)
$ in Thousands
42 Months Ended
Jan. 04, 2018
Mar. 31, 2021
Dec. 31, 2020
May 21, 2020
Description Of Business [Line Items]        
Accumulated deficit   $ (635,171) $ (577,530)  
Funds raised through Series A and Series B Convertible Preferred Stock, convertible note financings and completed IPO   $ 942,000    
AA Biopharma Inc.        
Description Of Business [Line Items]        
Cash received in connection with acquisition $ 12,800      
2027 Notes        
Description Of Business [Line Items]        
Debt instrument interest rate percentage   5.00%   5.00%