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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Cash flows from operating activities      
Net loss $ (180,307) $ (146,969) $ (6,771)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 917 297  
Stock-based compensation expense 20,819 30,947 32
In process research and development expenses 3,600 49,659  
Amortization of operating lease right-of-use assets 2,172    
Amortization of long-term debt discount and issuance costs 237    
Amortization of premium on investments, net of accretion of discounts (2,364)    
Net realized gain on investments (28)    
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets (4,393) (2,827) (130)
Other assets 2,714 (584)  
Operating lease liabilities (2,108)    
Accounts payable (1,399) 2,085 57
Accrued expenses 1,521 5,938 824
Accrued research and development expenses 8,605 10,527 126
Accrued compensation and benefits 5,180    
Accrued interest expense   (117) 117
Net cash used in operating activities (144,834) (51,044) (5,745)
Cash flows from investing activities      
Research and development asset acquisitions, net of cash acquired (3,600) (17,721)  
Purchase of marketable securities (499,079) (123,500)  
Maturities of marketable securities 328,000    
Sales of marketable securities 30,501    
Purchase of property and equipment (2,966) (3,490)  
Net cash used in investing activities (147,144) (144,711)  
Cash flows from financing activities      
Proceeds from issuance of convertible note     6,000
Proceeds from issuance of common stock in a public offering, net 291,311    
Proceeds from the issuance of long-term debt, net of debt discount and issuance costs of $1,778 28,222    
Proceeds from the exercise of stock options 2,045    
Repayment of notes payable to related parties   (40)  
Payment of deferred offering costs   (2,144)  
Net cash provided by financing activities 321,578 300,859 6,000
Effect of exchange rate changes on cash, cash equivalents and restricted cash 70    
Net increase in cash, cash equivalents and restricted cash 29,600 105,104 255
Cash, cash equivalents and restricted cash, at the beginning of the period 105,419 315 60
Cash, cash equivalents and restricted cash, at the end of the period 135,089 105,419 $ 315
Supplemental disclosure of cash flow information:      
Cash paid for interest 1,475 119  
Supplemental disclosure of noncash investing and financing activities:      
Acquisition of in-process research and development through issuance of stock   19,284  
Issuance of Series A convertible preferred stock to convert debt and accrued interest   6,124  
Unpaid deferred offering costs - net   1,545  
Right-of-use assets obtained in exchange for lease liabilities 12,458    
Conversion of convertible preferred stock to common stock 338,367    
Change in unrealized gain on marketable securities, net of tax 331 (61)  
Unpaid property and equipment $ 183    
Series A Convertible Preferred Stock      
Cash flows from financing activities      
Proceeds from issuance of convertible preferred stock, net   73,491  
Series B Convertible Preferred Stock      
Cash flows from financing activities      
Proceeds from issuance of convertible preferred stock, net   $ 229,552