Selected Quarterly Financial Information (Unaudited) - Schedule of Selected Quarterly Financial Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]
Loss from operations	$ (55,787)	$ (49,986)	$ (46,349)	$ (34,017)	$ (39,807)	$ (50,024)	$ (33,036)	$ (26,126)	$ (186,139)	$ (148,993)	$ (6,653)
Net loss	$ (54,698)	$ (48,500)	$ (44,498)	$ (32,611)	$ (38,794)	$ (49,409)	$ (32,729)	$ (26,037)	$ (180,307)	$ (146,969)	$ (6,771)
Per common share:
Net loss per share, basic and diluted	$ (0.89)	$ (0.80)	$ (0.74)	$ (0.90)	$ (4.92)	$ (8.03)	$ (5.52)	$ (4.31)	$ (3.29)	$ (22.59)	$ (0.74)