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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Cash flows from operating activities    
Net loss $ (32,611) $ (26,037)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 169 6
Stock-based compensation expense 3,089 605
In process research and development expenses 1,000 20,898
Changes in operating assets and liabilities:    
Operating lease right of use assets and liabilities, net 61  
Prepaid expenses and other current assets (3,472) (94)
Other Assets 2,144 (425)
Accounts payable 2,132 546
Accrued expenses (789) 441
Accrued research and development expenses 2,072 (126)
Accrued compensation and benefits (1,569) 593
Accrued interest expense   (115)
Net cash used in operating activities (27,774) (3,708)
Cash flows from investing activities    
Research and development asset acquisitions, net of cash acquired (1,000) 11,176
Purchase of investments (222,295)  
Sales and maturities of investments 25,500  
Purchase of property and equipment (347) (511)
Net cash (used in) provided by investing activities (198,142) 10,665
Cash flows from financing activities    
Proceeds from issuance of common stock in a public offering, net 291,273  
Proceeds from the exercise of stock options 71  
Proceeds from issuance of Series A convertible preferred stock, net   71,944
Repayment of notes payable to related parties   (40)
Net cash provided by financing activities 291,344 71,904
Net increase in cash, cash equivalents and restricted cash 65,428 78,861
Cash, cash equivalents and restricted cash, at the beginning of the period 105,419 315
Cash, cash equivalents and restricted cash, at the end of the period 170,847 79,176
Supplemental disclosure of noncash investing and financing activities:    
Acquisition of in-process research and development through issuance of stock   19,284
Issuance of Series A convertible preferred stock to convert debt and accrued interest   6,124
Recognition of operating lease right of use asset 12,458  
Recognition of operating lease liabilities 13,182  
Conversion of convertible preferred stock to common stock 338,367  
Change in unrealized gain on marketable securities, net of tax 140  
Unpaid property and equipment $ 739 $ 43