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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities:    
Net loss $ (95,247) $ (95,885)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,237 1,900
Amortization of debt discount and debt issuance costs 573 248
Loss on disposal of property and equipment 32 24
Equity-based compensation 21,536 17,053
Amortization/accretion of investment securities (494) 808
Non-cash operating lease expense 5,122 4,755
Change in operating assets and liabilities:    
Prepaid expenses and other current assets (1,633) (7,876)
Other assets (110) (84)
Accounts payable (2,245) (1,194)
Accrued expenses 5,322 4,120
Operating lease liabilities (5,460) (3,663)
Deferred revenue (33,193) (14,767)
Other liabilities (227) 227
Net cash used in operating activities (103,787) (94,334)
Cash flows from investing activities:    
Purchases of property and equipment (947) (4,706)
Purchases of marketable securities (290,828) (60,437)
Maturities of marketable securities 120,000 170,000
Net cash (used in) provided by investing activities (171,775) 104,857
Cash flows from financing activities:    
Proceeds from sale of common shares, pre-funded warrants and warrants to purchase common shares, net of issuance costs 195,315  
Proceeds from stock option exercises 487 5,269
Other   (19)
Net cash provided by financing activities 195,802 5,250
Net (decrease) increase in cash, cash equivalents and restricted cash (79,760) 15,773
Cash, cash equivalents and restricted cash, beginning of period 215,333 162,856
Cash, cash equivalents and restricted cash, end of period 135,573 178,629
Supplemental disclosure of non-cash items:    
Property and equipment purchases in accounts payable and accrued expenses 112 10
Supplemental cash flow information:    
Cash paid for interest $ 3,032 $ 1,494