Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of net losses before income taxes and loss on equity method investment by domestic and foreign operations

The amount of net loss before income taxes and loss on equity method investment for the years ended December 31, 2022, 2021 and 2020 is as follows (in thousands):

	Year ended December 31,
	2022		2021		2020
U.S. net loss before income taxes	$	(237,926)	$	(171,053)	$	(112,827)
Foreign net income (loss) before income taxes	344		4,663		(5,277)
Net loss before income taxes, including loss on equity method investment	$	(237,582)	$	(166,390)	$	(118,104)

Schedule of components of income tax provision (benefit) for federal and state income taxes

The following table presents the current and deferred income tax provision (benefit) for federal, state and foreign income taxes (in thousands):

	Year ended December 31,
	2022		2021		2020
Current tax provision:
Federal	$	—	$	—	$	—
State	11		11		16
Foreign	298		550		410
Total current tax provision	309		561		426
Deferred tax provision:
Federal	(683)		(120)		—
State	(41)		(736)		—
Foreign	(54)		(2)		18
Total deferred tax provision	(778)		(858)		18
Total provision for income taxes:	$	(469)	$	(297)	$	444

Schedule of effective income tax rate reconciliation

The following table is a reconciliation of the expected tax computed at the U.S. statutory federal income tax rate to the total provision for income taxes (in thousands):

	Year ended December 31,
	2022				2021				2020
Expected tax at 21%	$	(49,892)	21.0	%	$	(34,941)	21.0	%	$	(24,802)	21.0	%
State income tax, net of federal tax	(4,222)		1.8	%	(931)		0.6	%	273		(0.3)	%
Research credits	(12,558)		5.3	%	(6,938)		4.2	%	(4,025)		3.4	%
Share-based compensation	1,245		(0.5)	%	(3,307)		2.0	%	(1,718)		1.5	%
Other	(2,799)		1.2	%	939		(0.6)	%	146		(0.1)	%
Section 162(m) limitations	3,950		(1.7)	%	3,982		(2.4)	%	2,956		(2.5)	%
Change in valuation allowance	63,807		(26.9)	%	40,899		(24.6)	%	27,614		(23.4)	%
Provision for income taxes	$	(469)	0.2	%	$	(297)	0.2	%	$	444	(0.4)	%

Schedule of deferred tax assets and liabilities

Significant components of our net deferred tax asset or liability are as follows (in thousands):

	December 31,
	2022		2021
Deferred tax assets
Net operating loss	$	95,392	$	82,117
Compensation	1,937		1,553
Share-based compensation	7,735		4,123
ASC 842 lease liability	9,967		9,740
Intangibles	1,745		2,004
Capitalized research and experimental expenditures	30,776		—
Accrued liabilities	476		675
Research credits	27,024		14,466
Other	62		—
Total gross deferred tax assets	175,114		114,678
Valuation allowance	(160,967)		(97,160)
Net deferred tax assets	14,147		17,518
Deferred tax liabilities
Depreciable assets	(1,609)		(1,699)
ASC 842 right of use asset	(8,924)		(9,481)
Equity method investment	(4,467)		(7,954)
Other	—		(6)
Deferred tax liabilities	(15,000)		(19,140)
Net deferred tax liabilities	$	(853)	$	(1,622)

Schedule of unrecognized tax benefits roll forward

The following table summarized the activity related to our unrecognized tax benefits (in thousands):

	December 31,
	2022		2021		2020
Gross unrecognized tax benefits at the beginning of the year	$	2,835	$	1,932	$	1,124
Increase related to current year tax positions	1,112		969		661
Increase related to prior year tax positions	350		—		197
Decrease related to prior year tax positions	—		(66)		(50)
Gross unrecognized tax benefits at end of the year	$	4,297	$	2,835	$	1,932