License and Collaboration Agreements - Additional Information (Details)		1 Months Ended						3 Months Ended		12 Months Ended			55 Months Ended	56 Months Ended
	Jul. 13, 2020 USD ($) Program $ / shares shares	Jan. 31, 2022 USD ($)	Nov. 30, 2021 USD ($) Program	Jan. 31, 2021 USD ($) $ / shares shares	Nov. 30, 2019 USD ($)	Sep. 30, 2017 USD ($)	Aug. 31, 2017 USD ($)	Mar. 31, 2022 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2017 USD ($)	Mar. 31, 2022 USD ($)	Mar. 31, 2022 USD ($)	Dec. 30, 2021 USD ($)
License And Collaboration Agreements [Line Items]
Total collaboration and license revenues								$ 18,005,000	$ 9,461,000
Option continuation payment due upon second anniversary of agreement										$ 100,000,000
Deferred revenue recognized								18,005,000	9,461,000
Remaining capitalized fees at closing										3,800,000
Fees allocated among performance obligations										8,300,000
Development milestone expense									0
Development expense								61,211,000	66,387,000
Contract with customer liability, noncurrent								456,905,000		462,217,000			$ 456,905,000	$ 456,905,000
Gilead
License And Collaboration Agreements [Line Items]
Fee incurred to third party upon receipt of option exercise payments										4,500,000
WuXi Biologics License Agreement
License And Collaboration Agreements [Line Items]
Clinical and regulatory milestones achieved								$ 16,500,000
Range of tiered royalty payments on net sales								high single-digits to low teens
Development milestone expense								$ 1,500,000
WuXi Biologics License Agreement | Research and Development
License And Collaboration Agreements [Line Items]
Upfront cash payment								500,000
Sub-license fees incurred								0	0					11,300,000
Upfront and milestone payments														41,000,000.0
Development milestone payments								1,500,000
Milestone payments								0	10,000,000
WuXi Biologics License Agreement | Maximum
License And Collaboration Agreements [Line Items]
Clinical, regulatory and commercialization milestone payments							$ 375,000,000.0
Abmuno License Agreement
License And Collaboration Agreements [Line Items]
Upfront and milestone payments								14,600,000
Clinical, regulatory and commercialization remaining milestone payments								93,000,000.0
Development milestone expense								5,000,000.0	5,000,000.0
Genentech
License And Collaboration Agreements [Line Items]
Development expense								300,000	300,000
Gilead Collaboration Agreement
License And Collaboration Agreements [Line Items]
Option payment upon completion of certain IND-enabling activities	$ 60,000,000
Option payment upon achievement of certain development milestones	150,000,000
Deferred revenue								542,900,000		559,200,000			542,900,000	542,900,000
Increase (Decrease) in Operating expenses								(30,400,000)	(4,900,000)
Gilead Collaboration Agreement | Gilead
License And Collaboration Agreements [Line Items]
Upfront cash payment	$ 175,000,000
Collaboration term for current and future clinical programs	10 years
Contingent milestone payments receivable	$ 300,000,000
Additional collaboration term for programs entering clinical development prior to end of collaboration term	3 years
Option continuation payment receivable upon eighth anniversary of agreement	$ 100,000,000
Option continuation payment receivable upon fourth anniversary of agreement	100,000,000
Option continuation payment receivable upon sixth anniversary of agreement	100,000,000
Option fee per program for all other programs entering clinical development to exercise option	$ 150,000,000
Number of research programs | Program	2
Option payment upon achievement of certain development milestones	$ 250,000,000
Total collaboration and license revenues								5,000,000.0
Deferred revenue								213,800,000					213,800,000	213,800,000
Deferred revenue related to domvanalimab option															$ 36,700,000
Deferred revenue recognized										328,800,000
Deferred revenue related to etrumadenant option															127,000,000.0
Option payment upon achievement of certain development milestones	$ 275,000,000
Current and future programs exclusive access period	10 years
Performance obligation period	4 years
Contractual obligation remaining amount not obligated to pay	$ 300,000,000
Deferred revenue related to research and development pipeline								111,900,000					111,900,000	111,900,000	$ 91,700,000
Consultant and legal fees	7,300,000
Capitalized costs								100,000	100,000
Cost sharing receivable								4,800,000					4,800,000	4,800,000
Gilead Collaboration Agreement | Gilead | Prepaid Expenses and Other Current Assets
License And Collaboration Agreements [Line Items]
Capitalized costs to obtain the contract, current								800,000					800,000	800,000
Gilead Collaboration Agreement | Gilead | Other Noncurrent Assets
License And Collaboration Agreements [Line Items]
Receivable from collaboration partners- noncurrent								1,100,000					1,100,000	1,100,000
Capitalized costs to obtain the contract, noncurrent								4,000,000.0					4,000,000.0	4,000,000.0
Gilead Collaboration Agreement | Gilead | Maximum
License And Collaboration Agreements [Line Items]
Contingent milestone payments receivable	300,000,000
Potential regulatory approval milestones payment receivable related to domvanalimab	500,000,000
Gilead Collaboration Agreement | Taiho Pharmaceutical Co., Ltd
License And Collaboration Agreements [Line Items]
Option period						5 years
Option ending period						2022-09
Non refundable and non creditable cash payments												$ 35,000,000.0
Payment for first option exercise			$ 15,000,000.0
Purchase Agreement
License And Collaboration Agreements [Line Items]
Direct offering cost	1,900,000
Purchase Agreement | Gilead
License And Collaboration Agreements [Line Items]
Issuance of common stock	$ 200,000,000								220,296,000
Issuance of common stock, shares | shares	5,963,029										5,963,029
Shares issued, price per share | $ / shares	$ 33.54										$ 33.54
Percentage of option to purchase maximum shares of common stock	35.00%
Period over common stock to be purchased	5 years
Percentage of premium purchase price of common stock	20.00%
Trailing days average closing price	5 days
Share Price | $ / shares	$ 33.54
Funds received for purchase of common stock											$ 200,000,000
Purchase price of common stock allocation to performance obligation											$ 90,600,000
Purchase Agreement | Gilead | May 2020 Public Offering
License And Collaboration Agreements [Line Items]
Shares issued, price per share | $ / shares											$ 27.50
Additional equity investment net of offering costs											$ 56,700,000
Additional equity investment shares issued | shares											2,200,000
Amended Gilead Collaboration Agreement
License And Collaboration Agreements [Line Items]
Upfront cash payment										725,000,000
Issuance of common stock				$ 220,300,000
Issuance of common stock, shares | shares				5,650,000
Shares issued, price per share | $ / shares				$ 39.00
Option payments received		$ 725,000,000
Number of exercise option to programs | Program			3
Removal of option continuation payment under agreement			$ 100,000,000
Deferred revenue										165,100,000
Initial transaction price										890,100,000
Maximum ownership percentage of outstanding common stock remain unchanged				35.00%
Quemliclustat Option, and R&D Activities Agreement
License And Collaboration Agreements [Line Items]
Option payment upon achievement of certain development milestones								200,000,000
Total collaboration and license revenues								1,800,000
Deferred revenue								173,800,000					173,800,000	173,800,000
R&D activities for Domvanalimab
License And Collaboration Agreements [Line Items]
Total collaboration and license revenues								900,000
Deferred revenue								33,600,000					33,600,000	33,600,000
R&D and Commercialization Activities for Zimberelimab Monotherapy
License And Collaboration Agreements [Line Items]
Deferred revenue related to development and commercialization services								9,700,000					9,700,000	9,700,000
Total collaboration and license revenues								300,000
Deferred revenue								9,800,000					9,800,000	9,800,000
Access Rights related to Research and Development Pipeline
License And Collaboration Agreements [Line Items]
Total collaboration and license revenues								$ 8,300,000	7,700,000
Taiho Agreement | Taiho Pharmaceutical Co., Ltd
License And Collaboration Agreements [Line Items]
Payment for option exercise					$ 8,000,000.0								26,000,000.0
Range of royalties receivable on net sales								high single-digits to mid-teens
Royalties payable description								Royalties will be payable on a licensed product-by-licensed product and country-by-country basis during the period of time commencing on the first commercial sale of a licensed product in a country and ending upon the later of: (a) ten (10) years from the date of first commercial sale of such licensed product in such country; and (b) expiration of the last-to-expire valid claim of the Company’s patents covering the manufacture, use or sale or exploitation of such licensed product in such country (the Royalty Term).
Non-refundable, non-creditable upfront cash payments								$ 35,000,000.0
Estimated performance period								5 years
Clinical and regulatory milestones achieved								$ 0
Sales milestone or royalty revenue recognized								0
Deferred revenue, current								3,300,000		$ 5,000,000.0			3,300,000	3,300,000
Taiho Agreement | Taiho Pharmaceutical Co., Ltd | Minimum
License And Collaboration Agreements [Line Items]
Payment for option exercise						$ 3,000,000.0
Taiho Agreement | Taiho Pharmaceutical Co., Ltd | Maximum
License And Collaboration Agreements [Line Items]
Contingent milestone payments receivable						145,000,000.0
Payment for option exercise						15,000,000.0
Additional clinical and regulatory milestone payments receivable						$ 130,000,000.0
AstraZeneca Agreement
License And Collaboration Agreements [Line Items]
Development cost recorded within research and development expenses								1,200,000	$ 0
AstraZeneca Agreement | Other Long-term Liabilities
License And Collaboration Agreements [Line Items]
Contract with customer liability, noncurrent								2,300,000					$ 2,300,000	$ 2,300,000
Genentech Collaboration Agreement | Genentech
License And Collaboration Agreements [Line Items]
Development cost recorded within research and development expenses								$ 1,800,000