EX-4.6 12 bhsc_ex46.htm DEVELOPMENT AGREEMENT DATED JANUARY 1, 2024 BETWEEN THE COMPANY AND THE BIOPHARMACEUTICAL PARTNER Development Agreement dated January 1, 2024 between the Company and the Biopharmaceutical Partner

Certain portions of the exhibit have been redacted as such portions are not material and the type of information that the Company treats as private or confidential.

 

DEVELOPMENT AGREEMENT

 

THIS DEVELOPMENT AGREEMENT (the "Agreement") is made as of January 1, 2024 (the "Effective Date") by and between BioHarvest Sciences Inc., a Canadian company with a place of business at 1140 - 625 Howe Street VANCOUVER, BC V6C 2T6, Canada (together with its subsidiaries, "BioHarvest") and [NAME REDACTED], a company incorporated under the laws of [JURISDICTION REDACTED], with a place of business at [ADDRESS REDACTED] ("Partner"). BioHarvest and Partner are each herein referenced to as a "Party" or, collectively, as the "Parties".

 

WHEREAS BioHarvest has developed and is the owner of the Botanical Synthesis Open Platfo1m (the "BSOP"); The platfo1m perfo1ms the botanical synthesis of plants in order to produce consistent and patentable botanical compositions that can be applied for nutrition, nutraceuticals, cosmeceuticals, and pharmaceuticals. The botanical synthesis process is

based on growing the cells of the plant in industrial scale bioreactors without growing the plant itself;

 

WHEREAS Partner would like to engage Bi0Ha1vest to utilize its BSOP for the purpose of developing a single plant cell culture/line (per the attached Phase I SOW). The resulting cell culture will contain a unique botanical composition that can predict the future industrial scale values of its components; and

 

WHEREAS, the Patties wish to define the relationship between them in accordance with the terms and conditions set forth herein.

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties agree as follows:

 

1.DEFINITIONS 

 

The following capitalized te1ms have the meanings set forth below:

1.1"Affiliate" means, with respect to a person or entity, any other person or entity now or hereafter controlled by, controlling or lender common control with the first person or entity, for so long as such control exists, where "control" means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such entity, whether through ownership of more than 50% of the equity securities (or other equivalent interests), or of the majority of the voting rights, of the subject entity, by contract or othe1wise. 

1.2"Background IP" means with respect to each of BioHarvest or Pa1tner, all intellectual Property Rights which are solely owned (or duly licensed) and/or controlled by such Patty and which existed prior to the engagement between BioHarvest and Partner hereunder, or result from activities that are not part of the work under this Agreement and any SOW hereunder, or does not use or inco1porates the other Patty's intellectual Property Rights. 

1.3"Intellectual Property Rights" means all proprietary or other rights in and to: (i) patents and patent applications, including any additions, continuations, continuations-in-part, divisions, reissues, reexaminations, renewals or extensions based thereon; (ii) inventions (whether or not patentable), 


discoveries and improvements; (iii) copyrights, moral rights and similar rights in works of authorship, including documentation and computer programs in either source or executable code; (iv) rights in Know- How; (v) trademarks, trade names, designs, logos and trade dress; (vi) database rights, topography rights and other rights in semiconductor chips; and (vii) analogous rights under the laws of any jurisdiction worldwide; as well as any and all improvements, enhancements, derivative works, customizations, modifications, updates and upgrades to any of the aforementioned, if and as applicable.

 

1.4Know-How” means any trade secret, technology, method of manufacture, specifications, designs, drawings, or other information that is owned by either Party at any time or is created or arises during the conduct of the development pursuant to the SOW. 

 

 

2.GENERAL 

2.1Partner intends to engage BioHarvest for the purpose of developing a botanical composition/s with components values that have the ability to predict those of a final product that can be further produced (after the completion of Phases II and III, as defined below) at large scale, should Partner elect to do so using BioHarvest’s BSOP. 

 

2.2The collaboration between the Parties would involve three (3) different development phases, defined as Phase I, Phase II and Phase III. 

 

2.3By signing this Agreement Partner commits to engage BioHarvest in connection with Phase I only. Partner may, in its sole discretion, elect to engage BioHarvest in additional Phases, under additional SOW's to be agreed upon, provided that BioHarvest shall not be committed to advance to additional Phase(s) unless Partner has notified BioHarvest that it wishes to do so within no later than 60 days after the successful completion of the previous Phase. 

 

3.DEVELOPMENT EFFORTS 

3.1Phase I Development Activities. The Parties hereby agree to work in good faith to develop botanical compositions in accordance with the Statement of Work attached hereto as Exhibit A (the “Phase I SOW"). The Parties’ roles and responsibilities in connection with the development, the expected timing for the completion of the development, the materials that should be provided by Partner to BioHarvest, the success criteria, the BioHarvest deliverables and certain other terms and conditions related to the development efforts are set forth in the Phase I SOW. 

 

3.2Additional SOW's. Upon successful completion of the work under the Phase I SOW, the Parties may agree to move forward to Phase II and Phase III, each of which shall be covered by an additional agreed-upon SOW that will be subject to the general terms and conditions of this Agreement and will be added as additional Exhibits hereunder. 

3.3Account manager: BioHarvest will designate an account manager who will periodically communicate with Partner and coordinate any activities under all signed SOW's. The Partner reserves the right to request that the account manager will be replaced in case of un-satisfaction of the account manager’s performance. 


4.CONSIDERATION 

 

4.1In consideration for the performance of the Services, BioHarvest shall be entitled to receive a fee as specified in the relevant SOW. The fee for the Phase I SOW shall be [AMOUNT REDACTED], payable to BioHarvest's Israeli subsidiary, BioHarvest Ltd. 

4.2Payment is to be made in full within 30 days from end of the month in which the invoice was received by Partner. BioHarvest shall invoice Partner for the Phase I SOW according to the payment terms which will be agreed in the Phase I SOW. 

4.3All payments shall be made against proper invoices in accordance with applicable law. 

4.4Partner shall deduct at source any and all taxes as shall be due according to applicable law, unless BioHarvest provides written certification from the applicable Tax Authorities stating otherwise. 

4.5BioHarvest shall solely bear all taxes and duties due with respect to the services in applicable SOW and undertakes to pay all such taxes and duties. 

4.6The consideration of the Partner to BioHarvest shall be made to the following bank account: 

[BANK DETAILS REDACTED]

 

 

 

 

 

 

 

 

5.TERM AND TERMINATION 

5.1Term. This Agreement will begin on the Effective Date and will continue for a period of 3 years. 

 

5.2Termination for Convenience. After completion of the Phase I SOW, each Party can terminate a specific SOW or this Agreement upon giving the other party 60 days advance written notice. For clarity Phase I SOW may not be terminated by any Party for convenience. 

 

5.3Termination for Material Breach. Either Party may terminate the Agreement (including any SOW) if the other Party is in material breach of the Agreement or any SOW and has failed to cure that breach (if curable) within fourteen (14) days after the non-breaching Party’s written notice thereof. 

 

5.4Other Termination. Either Party may terminate this Agreement (including any SOW) immediately upon written notice to the other Party if the other Party: (i) makes an assignment in violation 


of this Agreement; (ii) ceases to carry on its business, liquidates or dissolves its business or disposes of a substantial portion of its assets; (iii) becomes insolvent or makes an assignment for the benefit of creditors; or (iv) voluntarily or involuntarily becomes the subject of any proceeding relating to bankruptcy, insolvency, receivership, liquidation or other similar proceeding.

 

5.5Effect of Termination. Upon receipt of such termination notice, with our without cause, BioHarvest will immediately cease all services and act in accordance with the Partner’s instructions and take necessary steps to wind down work in progress in an orderly fashion and in full compliance with all applicable regulatory and governmental requirements. In addition, the Partner will be charged only for the actual services which already incurred by BioHarvest up to the date of termination and the necessary costs for activities that are required to terminate the services in accordance with applicable laws and regulations. Upon termination or expiration of the Agreement for any reason, Sections 4-7, 11, 12 and 14 will survive. After expiration or termination of the Agreement, each Party will, upon the request of the other Party, return or destroy, at the election of the other Party (and provide certification of such destruction, if applicable) all Confidential Information of the other Party in its possession at the time of expiration or termination. 

 

6.INTELLECTUAL PROPERTY RIGHTS; EXCLUSIVE LICENSE 

6.1Ownership of Background IP. Each of BioHarvest and Partner shall retain ownership of its Background IP and nothing contained in this Agreement shall be construed as resulting in the assignment or transfer of any Background IP. 

 

6.2All materials, documents and information supplied by Partner to BioHarvest pursuant to the work rendered under this Agreement or any SOW, shall be the sole and exclusive property of the Partner and the Partner shall have the right to use all such materials in any way deemed by the Partner to be necessary or advisable either directly, or through agents, or otherwise, without any further payment to the BioHarvest. 

6.3Partner and BioHarvest agree that any BioHarvest Background IP which are used, improved, modified or developed by BioHarvest under the terms of this Agreement are the product of BioHarvest’s technical expertise possessed and developed by BioHarvest prior to or during the performance of any SOW and are the sole and exclusive property of BioHarvest. The Parties further agree that any SOW’s deliverables (other than the Background IP as is used, improved, modified or developed), including Botanical Compositions (as defined below) which result from the work performed under any SOW, shall be solely owned by Partner. For the purpose hereof, "Botanical Compositions" shall mean substance and/or formulations and/or mixtures that are botanical originated. 

 

6.4Each of the Parties declares that it is aware that the other Party's shares are publicly traded and that during the collaboration under this Agreement inside information as referred to in the applicable Securities Law ("Securities Law") may be made available to such Party. Such Party undertakes not to make any use of such insider information or to transfer it any third party, and all in accordance with the provisions of the Securities Law. 


6.5Reservation of Rights. All rights not expressly granted by either Party to the other Party hereunder are expressly reserved by the Party holding such rights. No licenses are granted by one Party to the other Party other than the licenses expressly granted in this Agreement. 

 

7.CONFIDENTIAL INFORMATION 

The confidentiality obligations of the Parties hereto with respect to all Confidential Information (as defined in the NDA) shall be as set forth in the Non-Disclosure Agreement signed by the Parties on (“NDA”) and the confidentiality obligations thereunder shall apply with respect to this Agreement.

 

8.NON-EXCLUSIVE RELATIONSHIP 

The collaboration between the Parties under this Agreement shall be on a non-exclusive basis, and nothing in this Agreement shall in any manner limit, restrict or preclude either Party from developing any technology or pursuing opportunities with a third party or independently.

 

9.COMPLIANCE WITH LAW; REGULATORY 

Partner and BioHarvest will each comply with all applicable national, state and local laws, ordinances, regulations and rules for the performance of their respective responsibilities and obligations under this Agreement, including applicable anti-bribery laws. The Parties will cooperate and provide reasonable assistance in obtaining any regulatory approvals, licenses, registrations and permits as may be required to perform any obligations under this Agreement. To the extent legally permissible, each Party will notify the other Party, as soon as reasonably practicable, if it becomes the subject of a government audit or investigation concerning the deliverables supplied under this Agreement.

 

10.REPRESENTATIONS AND WARRANTIES 

10.1Each Party represents and warrants to the other Party that: (i) it is duly organized, validly existing, and has full and adequate power and authority to enter into this Agreement, to grant the rights granted to the other Party hereunder and in any Exhibit and to perform its obligations hereunder and in any Exhibit; (ii) the execution, delivery and performance of this Agreement by such Party and the performance by such Party of the transactions contemplated in this Agreement have been duly and validly authorized by all necessary action, corporate or otherwise, on its part, and this Agreement constitutes the valid, legal and binding obligation of such Party; and (iii) such Party is not and will not be subject to any agreement or other constraint that does, would or with the passage of time would prohibit, conflict with or restrict such Party’s right or ability to enter into or carry out its obligations hereunder. 

 

10.2BioHarvest represents, warrants and undertakes that it shall perform the services set forth in any SOW in a faithful, diligent, and professional manner using reasonable care and skill, provided that no assurance is made that the development efforts under any SOW shall be successful or meet any intended results. 

 

10.3BioHarvest represents, warrants and undertakes it obtains any licenses and/or permits and/or authorizations required to fulfill its duties and works under this Agreement and any SOW. 


 

 

11.LIABILITY 

 

11.1TO THE FULLEST EXTENT PERMISSIBLE BY LAW NEITHER PARTY SHALL BE LIABLE UNDER THIS AGREEMENT, FOR ANY INDIRECT, EXEMPLARY, SPECIAL, CONSEQUENTIAL, OR INCIDENTAL DAMAGES OF ANY KIND, OR ANY LOSS OF PROFITS, LOSS OF REPUTATION OR LOSS OF GOOD WILL, EVEN IF A PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES OR LOSSES. IN ADDITION, EITHER PARTY'S AGGREGATE LIABILITY TO THE OTHER SHALL BE LIMITED TO THE AGGREGATE AMOUNTS PAID (OR PAYABLE) BY PARTER UNDER ALL SOW'S. THE FOREGOING LIMITATIONS SHALL NOT APPLY TO DAMAGES DUE TO ANY PARTY'S WILLFUL MISCONDUCT, BODILY INJURIES, INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OR BREACH OF CONFIDENTIALITY OBLIGATIONS. 

 

12.INDEMNIFICATION AND INSURANCE 

 

12.1BioHarvest agrees to indemnify, defend and save the Partner harmless from and against any and all claims, injuries, disabilities, losses, fines, penalties, costs, expenses (including attorneys' fees), damages or liabilities (“Claims”) (i) based upon damage to, or destruction of any property or injury (including death) that the Partner, any of its employees, or any other person may suffer or sustain as a result of any act or omission of BioHarvest or its employees; (ii) any violation of Applicable Laws; and if the work under any SOW infringe any third party's intellectual property right. For any such Claims BioHarvest agrees to release and waive, and hereby releases and waives, all rights of subrogation against the Partner possessed by the BioHarvest's insurers. Any such indemnification shall be subject to Partner notifying BioHarvest of any such Claim as promptly as possible, provided however, that failure of the Partner to give such notice shall not limit the Partner’s right to indemnification except in such case where such failure materially and adversely affects BioHarvest’s ability to defend against such Claim. BioHarvest shall solely assume the control and defense of any such Claim. BioHarvest shall not compromise or settle any Claim that includes an admission of guilt by Partner without the prior written approval of the Partner. 

 

12.2BioHarvest shall obtain and maintain in full force and effect, at no cost to the Partner, insurance policies, having policy limits and terms appropriate to the conduct of BioHarvest’s business in the amount reasonably adequate to cover its obligations under this Agreement and applicable SOW until the later date (i) termination of the Agreement (ii) as long as legal liability exists. 


13.GENERAL 

13.1Independent Contractor. The relationship of BioHarvest and Partner established by this Agreement is that of independent contractors. No Party has any express or implied right or authority to assume or create any obligations on behalf of or in the name of the other Party or to bind the other Party to any contract, agreement or undertaking with any third party without the express consent of such other Party. 

 

13.2Notices. All notices and other communications given or made pursuant to this Agreement shall be in writing and shall be deemed effectively given upon the earlier of actual receipt, or (i) when delivered, if sent by personal delivery to the party to be notified, (ii) when sent, if sent by electronic mail or facsimile (with electronic conformation of delivery) on a business day and during normal business hours of the recipient, and otherwise on the first business day in the place of recipient, (iii) five (5) business days after having been sent, if sent by registered or certified mail, return receipt requested, postage prepaid, or (iv) one (1) business day after deposit with an internationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written confirmation of receipt. All communications shall be sent to the respective parties at their address as set forth on the signature page or to such e-mail address, facsimile number or address as subsequently modified by written notice given in accordance with this Section. 

 

13.3No Joint Venture. Nothing contained in this Agreement shall constitute a joint venture by the Parties. Neither Party shall have the right to contract on behalf of or bind the other Party or make any commitment, representation or warranty for or on behalf of the other Party. 

 

13.4Use of Trademarks and Logos. Without derogating from any other agreement between the Parties, neither Party shall use the other Party’s trademarks, service marks, graphic symbol, logo or icon on or in connection with websites, products, packaging, manuals, promotional or advertising materials, or for any other purpose except pursuant to the prior written consent of the other Party. 

 

13.5Assignment. Neither Party may assign its rights, interests and obligations under this Agreement without the prior written consent of the other Party, which will not be unreasonably withheld; provided that each Party shall have the right to assign its rights, interests and obligations under this Agreement and any Exhibit without the prior written consent of the other Party to (i) an Affiliate; or (ii) in connection with a merger or the sale of all or substantially all of the assigning party’ assets or stock on the condition that such assignment shall be solely to the acquirer or purchaser of the assigning party and such acquirer or purchaser must assume the assigning party’s obligations under this Agreement to the other party. 

 

13.6Entire Agreement. This Agreement and any Exhibit, together with the side letter entered into between the Parties on the Effective Date, contain the entire agreement of the Parties regarding the subject matter described herein, and all other promises, representations, understandings, arrangements and prior agreements related thereto are merged herein and superseded hereby. The provisions of this 


Agreement may not be amended except by an agreement in writing signed by authorized representatives of both Parties.

 

13.7Interpretation. In the event of any ambiguity or discrepancy between the provisions of this Agreement and the SOW, the provisions of the SOW shall prevail. 

13.8Applicable Law; Jurisdiction. This Agreement shall be governed by and construed in accordance with the laws of the State of New York. The parties agree that any suit or proceeding in connection with, arising out of or relating to, this Agreement shall be instituted exclusively and only in a court of law located in, New York, USA, and the parties hereby irrevocably agree and submit to the jurisdiction and venue of any such proceeding, and agree that service of process may be effected in the same manner notice is given hereunder. 

 

13.9Counterparts. This Agreement may be executed in one or more counterparts, all of which together shall constitute one and the same instrument. Counterparts may also be delivered by facsimile or email transmission (in pdf format or the like, or signed with docusign, e-sign or any similar form of signature by electronic means) 

 

 

 

[Signature Page to Follow]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


IN WITNESS WHEREOF, BioHarvest and Partner have each caused this Agreement to be signed and delivered by its duly authorized officer as of the Effective Date, in one or more connterpru1s.

 

 

 

BIOHARVEST SCIENCES INC.

 

PARTNER

 

 

 

By:

“Ilan sobel”

 

By:

“Signed”

Printed:

Ilan Sobel

 

Printed:

[NAMES REDACTED]

Title:

CEO

 

Title:

CFO  CEO

Date:

05/01/24

 

Date:

2-Jan-2024    12-Dec-2023

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


 

EXHIBIT A

 

Phase I SOW

 

[STATEMENT OF WORK REDACTED]