Alliance and Collaboration - Additional Information (Details) - USD ($)		3 Months Ended		6 Months Ended		57 Months Ended
	May 07, 2018	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Expensed to costs of goods sold		$ 322,577,000	$ 319,666,000	$ 624,120,000	$ 633,244,000
Research and development		52,864,000	45,572,000	101,046,000	81,951,000
Astra Zeneca
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative arrangement reduced royalty						$ 30,000,000
Expensed to costs of goods sold		3,000,000	5,000,000	6,000,000	9,000,000
Biosimilar Licensing and Supply Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative arrangement maximum contingent payments amount	$ 78,000,000
Research and development		$ 8,000,000	$ 5,000,000	$ 10,000,000	$ 5,000,000