August 16, 2018

Tiziano Lazzaretti
Chief Financial Officer
Tiziana Life Sciences plc
3rd Floor, 11-12 St. James's Square
London SW1 4LB, United Kingdom

       Re: Tiziana Life Sciences plc
           Registration Statement on Form F-1
           Filed July 26, 2018
           File No. 333-226368

Dear Mr. Lazzaretti:

       We have reviewed your registration statement and have the following
comments. In
some of our comments, we may ask you to provide us with information so we may
better
understand your disclosure.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comments apply to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to these comments, we may have additional comments.

Registration Statement on Form F-1

Cover page

1.     We note your statement that no assurance can be given that your
application to list your
       American Depositary Shares on the Nasdaq Capital Market will be
approved. If your
       offering is not contingent on listing approval, please revise your cover
page disclosure to
       clarify this fact. Additionally, please include a risk factor describing
the consequences of
       not securing Nasdaq listing approval.
2.     We note your disclosure that the last reported sale price of your
ordinary shares on AIM
       was   ___ per ordinary share, equivalent to $ ___ per ADS. You may use
the most recent
       home market trading price, converted to U.S. dollars at the most recent
exchange rate,
 Tiziano Lazzaretti
FirstName LastNameTiziano Lazzaretti
Tiziana Life Sciences plc
Comapany NameTiziana Life Sciences plc
August 16, 2018
August 16, 2018 Page 2
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FirstName LastName
         assuming the U.S. IPO price will be substantially similar to the home
market trading price.
         If you expect that the U.S. IPO price will not be substantially
similar to the home market
         trading price, please disclose on the prospectus cover page a bona
fide price range of the
         offered securities. If you intend to price the securities based on the
AIM market price, you
         may disclose a percentage range based on that price (for example, 10%
of the home
         market price) within which you intend to price the securities. See
Item 501(b)(3) of
         Regulation S-K.
Prospectus Summary
Our Strategy, page 3

3.       We note your statement that your goal is to deliver best-in-class and
potentially life-
         altering therapies. Given the development stage of your product
candidates and length of
         the drug approval process, it is premature and inappropriate for you
to imply that any of
         your product candidates will ultimately be approved or become
best-in-class or life-
         altering. Please remove this statement here and on page 65.
Our Product Candidates
Clinical Development Pipeline, page 4

4.       We note your disclosure on page 1 that you plan to initially
investigate Foralumab for
         safety and its immunomodulatory activity in healthy volunteers in two
Phase 1 trials.
         Please revise your pipeline development chart to remove the studies
conducted by
         Novimmune for the intravenous formulation and ensure that it
accurately reflects the
         development status for your stated strategy. Additionally, with
respect to references to the
         studies conducted by Novimmune, please revise your disclosure to
remove your
         conclusions, i.e., "encouraging clinical response," to reference
objective data points from
         which your conclusions were drawn.
Implications of Being an Emerging Growth Company, page 5

5.       Please supplementally provide us with copies of all written
communications, as defined in
         Rule 405 under the Securities Act, that you, or anyone authorized to
do so on your behalf,
         present to potential investors in reliance on Section 5(d) of the
Securities Act, whether or
         not they retain copies of the communications.
Use of Proceeds, page 48

6.       Please revise the Use of Proceeds discussion to quantify the amounts
you expect to
         allocate to Miliciclib and Foralumab separately. It appears from your
disclosure that the
         proceeds from the offering will not be sufficient to fund development
of your product
         candidates through regulatory approval and commercialization. Please
indicate how far
         the proceeds from the offering will allow you to proceed with the
continued development
         of Milciclib and Foralumab. Also disclose the sources of other funds
needed to reach
 Tiziano Lazzaretti
FirstName LastNameTiziano Lazzaretti
Tiziana Life Sciences plc
Comapany NameTiziana Life Sciences plc
August 16, 2018
August 16, 2018 Page 3
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FirstName LastName
         regulatory approval and commercialization for each product candidate.
Refer to Item 3.C
         of Form 20-F required by Item 4 of Form F-1.
Business
Our Product Candidates
Crohn's Disease, page 67

7.       Please define scientific terms such as "anti-CD4 and TNF binding mABs"
and tell us what
         you mean by "induction of apoptosis of activated T-lymphocytes rather
than neutralization
         of soluble TNF." Please also cite the referenced previously reported
studies and provide
         support for your conclusion regarding TNF targeting mAbs in Crohn's
disease.
Proposed Phase 1 Clinical Trial for Foralumab for the Treatment of Multiple
Sclerosis, page 70

8.       In the second paragraph you indicate that Intravenous Foralumab was
studied in three
         Phase 1 and Phase 2 clinical trials in 68 patients. In the third
paragraph you indicate that
         68 of the partiicpants in the trials had Crohn's disease and 11 had
acute cellular allograft
         rejection. Please clarify the discrepancy. Additionally, for each
trial, expand your
         disclosure to include the duration of the trial, primary and secondary
endpoints and
         whether these endpoints were met, as well as all serious adverse
events.
Milciclib (TZLS-201)
Phase 1 Development, page 70

9.       For each of your trials CDKO-125a-003 and CDKO 125a-004, please revise
your
         disclosure to explain what you mean by "clinically significant"
disease stabilization in
         terms of objective data points.
Research and Development, page 84

10.      We note your references to Milciclib as having a "good safety profile"
and demonstrated
         to be "efficacious." Please revise your disclosure to remove these
statements as
         determinations of safety and efficacy are solely within the authority
of the U.S. Food and
         Drug Administration and comparable regulatory bodies.
Consolidated Statements of Shareholders' Equity, page F-5

11.      It is apparent that your 2016 and 2017 equity statements do not foot
and cross-foot
         appropriately. Please revise these statements to correct the following
footing and cross-
         footing discrepancies:
           2017 Share Capital total transactions with owners subtotal does not
foot;
           2016 and 2017 Share Premium total transactions with owners subtotal
does not foot;
           2017 Convertible Loan Note Reserve total transactions with owners
subtotal does not
              foot;
           Retained Earnings balance at December 31, 2016 does not foot;
 Tiziano Lazzaretti
FirstName LastNameTiziano Lazzaretti
Tiziana Life Sciences plc
Comapany NameTiziana Life Sciences plc
August 16, 2018
Page 4
August 16, 2018 Page 4
FirstName LastName
             Translation Reserve balance at December 31, 2017 does not foot;
             2017 Capital Reduction Reserve total transactions with owners
subtotal does not foot;
             Capital Reduction Reserve at December 31, 2017 does not foot;
             2016 and 2017 Total Equity for the transactions with owners
subtotal does not foot;
             Total Equity balance at December 31, 2016 does not foot; and
             Total transactions with owners subtotal for both 2016 and 2017
does not cross-foot.
Consolidated Statements of Cash Flows, page F-6

12.      Please revise to label the beginning item in your presentation of cash
flows from operating
         activities as Loss from operations before income taxes or revise to
use the amount of the
         net loss for the periods presented.
11. Loss Per Share, page F-14

13.      Please address the following comments regarding your loss per share
computations:
           Explain to us why you appear to use your comprehensive loss in the
numerator of your
            2017 loss per share computation instead of your loss for the year.
Otherwise, revise
            your computation and disclosure accordingly.
           As you classify the Convertible Loan Notes disclosed in Note 18 as
equity, explain to
            us why the interest accrued on these notes is not treated similar
to preferred dividends
            in the numerator of your loss per share computation consistent with
the the guidance in
            paragraphs 12 through 18 of IAS 33. Otherwise, revise your loss per
share
            computations in 2016 and 2017 to reflect the interest accrued on
these notes as
            a deduction in the numerator tantamount to a dividend on the
underlying equity
            instruments.

         To the extent that you revise your loss per share computations,
provide the error
         correction disclosure required by paragraph 49 of IAS 8.
Notes to Consolidated Financial Statements
10. Taxation, page F-14

14.      Please address the following comments regarding the income tax benefit
reflected in your
         financial statements:
           Tell us why it is appropriate to reflect the benefits recorded and
how they are
             realizable given your historical losses.
           Revise your disclosure to describe the basis for the Research and
development claim
             provided in your reconciliation of your tax credit to the
statutory rate. In addition,
             separately tell us how this claim is based on taxable profits to
be recorded as an
             income tax benefit as stipulated in paragraph 2 of IAS 12 and why
it is not reflected as
             a reduction of research and development expenses as indicated in
the second
             paragraph on page 57.
           Revise your disclosure to describe the nature of the Adjustments due
to prior periods
 Tiziano Lazzaretti
Tiziana Life Sciences plc
August 16, 2018
Page 5
          included in your reconciliation of the tax credit to the statutory
rate for 2017.
          Separately tell us why these adjustments are not the correction of
errors that should be
          reflected in earlier periods under IAS 8.
          Revise your disclosure to include a discussion of the tax impact for
the year in the
          Management's Discussion and Analysis of Financial Condition and
Results of
          Operations narrative on page 59.
General

15.   Please provide us proofs of all graphics, visual, or photographic
information you will
      provide in the printed prospectus prior to its use, for example in a
preliminary prospectus.
      Please note that we may have comments regarding this material.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       You may contact Rolf Sundwall at 202-551-3105 or Mark Brunhofer at
202-551-3638 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Christine Westbrook at 202-551-5019 or Mary Beth Breslin at
202-551-3625 with any
other questions.



                                                            Sincerely,
FirstName LastNameTiziano Lazzaretti
                                                            Division of
Corporation Finance
Comapany NameTiziana Life Sciences plc
                                                            Office of
Healthcare & Insurance
August 16, 2018 Page 5
cc:       Ed Lukins, Esq.
FirstName LastName